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NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36
CONCLUSION: We show novel evidence for the CD36-mediated accumulation of oxLDL in BAT, suggesting that BAT may exert its anti-atherogenic effects by removing atherogenic LDL from the circulation.PMID:36266737 | DOI:10.1093/cvr/cvac167
Source: Cell Research - October 21, 2022 Category: Cytology Authors: Kento Hosomi Hidekazu Kawashima Atsushi Nakano Akemi Kakino Yuko Okamatsu-Ogura Yuki Yamashita Mai Sasaoka Daisaku Masuda Shizuya Yamashita Chu-Huang Chen Shunsuke Yuzuriha Hiroshi Hosoda Hidehiro Iida Tatsuya Sawamura Source Type: research

A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity.
In conclusion, these studies provide evidence that within the hypothalamic nuclei, leptin-glutamate signaling regulates the sympathetic activation. This may contribute to the sympathoexcitation commonly observed in obesity-related T2D. PMID: 28845307 [PubMed - in process]
Source: Neural Plasticity - August 30, 2017 Category: Neurology Authors: Zheng H, Liu X, Li Y, Patel KP Tags: Neural Plast Source Type: research

PTEN, a negative regulator of PI3K/Akt signaling, sustains brain stem cardiovascular regulation during mevinphos intoxication.
Abstract Activation of PI3K/Akt signaling, leading to upregulation of nitric oxide synthase II (NOS II)/peroxynitrite cascade in the rostral ventrolateral medulla (RVLM), the brain stem site that maintains blood pressure and sympathetic vasomotor tone, underpins cardiovascular depression induced by the organophosphate pesticide mevinphos. By exhibiting dual-specificity protein- and lipid-phosphatase activity, phosphatase and tensin homolog (PTEN) directly antagonizes the PI3K/Akt signaling by dephosphorylation of phosphatidylinositol-3,4,5-trisphosphate, the lipid product of PI3K. Based on the guiding hypothesis t...
Source: Neuropharmacology - June 7, 2017 Category: Drugs & Pharmacology Authors: Tsai CY, Wu JCC, Fang C, Chang AYW Tags: Neuropharmacology Source Type: research

Pannexin 1 Channels Mediate the Release of ATP into the Lumen of the Rat Urinary Bladder.
This article is protected by copyright. All rights reserved. PMID: 25630792 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - January 29, 2015 Category: Physiology Authors: Beckel JM, Daugherty SL, Tyagi P, Wolf-Johnston AS, Birder LA, Mitchell CH, de Groat WC Tags: J Physiol Source Type: research