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Oligonucleotides —A Novel Promising Therapeutic Option for IBD
Conclusions In this review, we focused on recent and past approaches to test the therapeutic efficacy of oligonucleotide based therapies in IBD. The combining mechanistic mode of oligonucleotide based therapeutics is a targeted action on specific pro-inflammatory molecules, which are over activated in IBD patients and contribute significantly to disease pathogenesis. The proposed high selectivity of the agents is derived from its mode of action, that aims to specifically block certain inflammatory molecular patterns, without a general systemic effect on other molecular targets. It would be important for each oligonucleot...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Cholesterol modification of SDF-1-specific siRNA enables therapeutic targeting of angiogenesis through Akt pathway inhibition.
Abstract Neovascularization during ocular tissue repair can cause severe visual loss in the optical axis and is therefore an issue of considerable concern to ophthalmologists. Here, we introduced a cholesterol-modified siRNA delivery system targeting stromal cell-derived factor 1 (SDF-1) to treat ocular angiogenesis in vivo. SDF-1 expression was analyzed in rat endothelial progenitor cells (EPCs) and bone marrow mesenchymal stem cells (BMSCs) using quantitative PCR (qPCR). Migration ability of BMSC and HUVEC were assessed through transwell assay. The proliferation effect of chol-siSDF1 on HUVEC was measured by col...
Source: Experimental Eye Research - March 17, 2019 Category: Opthalmology Authors: Chen J, Li F, Xu Y, Zhang W, Hu Y, Fu Y, Xu W, Ge S, Fan X, Lu L Tags: Exp Eye Res Source Type: research

Nitric oxide promotes epidermal stem cell proliferation via FOXG1-c-Myc signalling
Conclusion This study showed that the biphasic effect of NO on ESC proliferation as well as NO induced ESC proliferation were regulated by the cGMP/FOXG1/c-Myc signalling pathway, suggesting that NO may serve as a new disparate target for wound healing.
Source: Nitric Oxide - December 14, 2017 Category: Chemistry Source Type: research

Nucleolin Enhances the Proliferation and Migration of Heat‐denatured Human Dermal Fibroblasts
This article is protected by copyright. All rights reserved.
Source: Wound Repair and Regeneration - March 1, 2015 Category: Surgery Authors: Bimei Jiang, Yuanbin Li, Pengfei Liang, Yanjuan Liu, Xu Huang, Zhongyi Tong, Pihong Zhang, Xiaoyuan Huang, Ying Liu, Zhenguo Liu Tags: Original Research–Basic Science Source Type: research