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Sevoflurane preconditioning promotes mesenchymal stem cells to relieve myocardial ischemia/reperfusion injury via TRPC6-induced angiogenesis
CONCLUSION: The current findings reveal that sevoflurane preconditioned MSCs boost angiogenesis in HUVECs subjected to H/R insult and attenuate myocardial I/R injury, which may be mediated by TRPC6 up-regulated HIF-1α, CXCR4 and VEGF.PMID:34809715 | DOI:10.1186/s13287-021-02649-3
Source: Cell Research - November 23, 2021 Category: Cytology Authors: Jinting Yang Lihui Tang Fengjiang Zhang Tingting Yang Ting Lu Kai Sun Na Sun Jinxuan Ren Min Yan Source Type: research

ILK regulates MSCs survival and angiogenesis partially through AKT and mTOR signaling pathways.
This study examined the role and mechanism of ILK in MSCs survival and angiogenesis. In hypoxic condition, upregulation of ILK expression increased the phosphorylation of Akt and mTOR, resulting in markedly enchanced MSCs survival and VEGF expression; while significantly inhibited MSCs survival and VEGF expression was detected in MSCs with ILK kinase inactivation, which was associated with a reduction of phosphorylation of Akt and mTOR. In addition, it also caused an inhibitory effects of ILK on MSCs survival and VEGF expression, which was abolished by Akt or mTOR inhibitor. Furthermore, it was observed that ILK-overexpres...
Source: Acta Histochemica - April 28, 2017 Category: Biochemistry Authors: Zeng B, Liu L, Wang S, Dai Z Tags: Acta Histochem Source Type: research

Specific inhibition of HDAC4 in cardiac progenitor cells enhances myocardial repairs
We have recently shown that in vivo inhibition of histone deacetylase (HDAC) stimulates endogenous myocardial regeneration in infarcted hearts (Zhang L et al. J Pharmacol Exp Ther 341: 285–293, 2012). Furthermore, our observation demonstrates that HDAC inhibition promotes cardiogenesis, which is associated with HDAC4 reduction. However, it remains unknown as to whether specific inhibition of HDAC4 modulates cardiac stem cells (CSCs) to facilitate myocardial repair and to preserve cardiac performance. c-kit+ CSCs were isolated from adult mouse hearts and were transfected with HDAC4 siRNA to knockdown HDAC4 of c-kit+ C...
Source: AJP: Cell Physiology - August 15, 2014 Category: Cytology Authors: Zhang, L. X., DeNicola, M., Qin, X., Du, J., Ma, J., Tina Zhao, Y., Zhuang, S., Liu, P. Y., Wei, L., Qin, G., Tang, Y., Zhao, T. C. Tags: ARTICLES Source Type: research

Specific Inhibition of HDAC4 in Cardiac Progenitor Cells Enhances Myocardial Repairs.
Abstract We have recently shown that in vivo inhibition of histone deacetylase (HDAC) stimulates endogenous myocardial regeneration in infarcted hearts. Furthermore, our observation demonstrates that HDAC inhibition promotes cardiogenesis, which is associated with HDAC4 reduction. However, it remains unknown as to whether specific inhibition of HDAC4 modulates cardiac stem cells (CSCs) to facilitate myocardial repair and to preserve cardiac performance. c-kit(+)CSCs were isolated from adult mouse hearts and were transfected with HDAC4siRNA to knockdown HDAC4 of c-kit(+)CSCs. The transfection of HDAC4siRNA caused a...
Source: Am J Physiol Cell Ph... - June 18, 2014 Category: Cytology Authors: Zhang LX, DeNicola M, Qin X, Du J, Ma J, Zhao TY, Zhuang S, Liu PY, Wei L, Qin G, Tang Y, Zhao TC Tags: Am J Physiol Cell Physiol Source Type: research