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OTUD7B (Cezanne) ameliorates fibrosis after myocardial infarction via FAK-ERK/P38 MAPK signaling pathway
Arch Biochem Biophys. 2022 May 3:109266. doi: 10.1016/j.abb.2022.109266. Online ahead of print.ABSTRACTFibrosis is one of the crucial reasons for cardiac dysfunction after myocardial infarction (MI). Understanding the underlying molecular mechanism that causes fibrosis is crucial to developing effective therapy. Recently, OUT domain-containing 7B (OTUD7B), also called Cezanne, a multifunctional deubiquitylate, has been found to play various roles in cancer and vascular diseases and control many important signaling pathways, including inflammation, proliferation, and so on. However, whether OTUD7B plays a role in fibrosis c...
Source: Archives of Biochemistry and Biophysics - May 6, 2022 Category: Biochemistry Authors: Jiayan Zhang Yafang Zha Yuheng Jiao Yanyan Li Jian Wang Song Zhang Source Type: research

Inhibition of lncRNA < em > SNHG8 < /em > plays a protective role in  hypoxia-ischemia-reoxygenation-induced myocardial injury by regulating miR-335 and RASA1 expression
Mol Med Rep. 2021 Aug;24(2):597. doi: 10.3892/mmr.2021.12236. Epub 2021 Jun 24.ABSTRACTLong non‑coding (lnc)RNAs serve a role in a number of diseases, including different types of cancer and acute myocardial infarction. The aim of the present study was to investigate the protective role of lncRNA small nucleolar RNA host gene 8 (SNHG8) in hypoxia‑ischemia‑reoxygenation (HI/R)‑induced myocardial injury and its potential mechanism of action. Cell viability, proliferation, creatine kinase myocardial band, cell apoptosis and protein expression levels were determined by Cell Counting Kit‑8 assay, EdU assay, ELISA, flo...
Source: Molecular Medicine Reports - June 24, 2021 Category: Molecular Biology Authors: Yanfeng Liu Ping Zhou Fengxiao Wang Xuehong Zhang Dongmei Yang Lang Hong Dongyun Ruan Source Type: research

p27-Regulated Cardiac Autophagy Cell Biology
p27Kip1 (p27), a key regulator of cell division, has been implicated in autophagy of cancer cells. However, its role in autophagy, the evolutionarily conserved catabolic process that enables cells to remove unwanted proteins and damaged organelles, had not been examined in the heart. Here we report that ectopic delivery of a p27 fusion protein (TAT-p27) was sufficient to induce autophagy in neonatal rat ventricular cardiomyocytes in vitro, under basal conditions and after glucose deprivation. Conversely, lentivirus-delivered shRNA against p27 successfully reduced p27 levels and suppressed basal and glucose-deprived levels ...
Source: Journal of Biological Chemistry - June 12, 2014 Category: Chemistry Authors: Sun, X., Momen, A., Wu, J., Noyan, H., Li, R., von Harsdorf, R., Husain, M. Tags: Molecular Bases of Disease Source Type: research

COX-2 Signaling and Cancer: New Players in Old Arena.
Abstract Cancer is a leading cause of death worldwide. The expression of COX-2 and prostaglandins has not only been associated with various types of cancer but is also directly proportional to their aggressiveness including metastasis. Thus, inhibition of COX-2 activity has been one of the preferred targets for cancer reduction. Broad spectrum inhibition of all forms of COX (using NSAIDs) is associated with various side effects ranging from gastric ulceration to renal problems. Even specific COX-2 inhibitors (COXIBS) are associated with side effects like myocardial infarction. Alternative strategies including siRN...
Source: Current Drug Targets - January 26, 2014 Category: Drugs & Pharmacology Authors: Misra S, Sharma K Tags: Curr Drug Targets Source Type: research