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Dopamine 1 receptor activation protects mouse diabetic podocytes injury via regulating the PKA/NOX-5/p38  MAPK axis.
In conclusion, D1R activation can protect diabetic podocytes from apoptosis and oxidative damage, in part through the PKA/NOX-5/p38 MAPK pathway. PMID: 31954110 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - January 14, 2020 Category: Cytology Authors: Shao X, Zhang X, Hu J, Gao T, Chen J, Xu C, Wei C Tags: Exp Cell Res Source Type: research

Klotho improves diabetic cardiomyopathy by suppressing the NLRP3 inflammasome pathway
Publication date: Available online 15 August 2019Source: Life SciencesAuthor(s): Xuelian Li, Zhiyang Li, Bingong Li, Xianjie Zhu, Xingjun LaiAbstractAimsNLRP3 inflammasome activation is essential for the development and prognosis of diabetic cardiomyopathy (DCM). The anti-aging protein Klotho is suggested to modulate tissue inflammatory responses. The aim of the present study was to examine the protective effects of Klotho on DCM.Main methodsA streptozotocin-induced diabetes mouse model was established to assess the effects of Klotho in vivo, which was administered for 12 weeks. The characteristics of type 1 DCM were eva...
Source: Life Sciences - August 18, 2019 Category: Biology Source Type: research