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Condition: Renal Failure
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Total 60 results found since Jan 2013.
MicroRNA-17-5p promotes vascular calcification by targeting ANKH
CONCLUSION: Our data showed that miR-17-5p may promote vascular calcification by inhibiting ANKH expression.PMID:35297350 | DOI:10.2174/1567202619666220316115425
Source: Current Neurovascular Research - March 17, 2022 Category: Neurology Authors: Chao Shi Jiaorong Tan Jiancan Lu Junling Huang Xiangqi Li Jiahong Xu Xing Wang Source Type: research
Endoplasmic reticulum stress mediates parathyroid hormone-induced apoptosis in vascular smooth muscle cells
Ren Fail. 2022 Dec;44(1):126-136. doi: 10.1080/0886022X.2022.2027248.ABSTRACTVascular calcification is one of the most common complications of chronic kidney disease (CKD), which is closely associated with increased mortality and morbidity rates of CKD patients. It has been reported that increased parathyroid hormone (PTH) aggravates vascular calcification in CKD patients. However, the direct role of PTH in vascular smooth muscle cells (VSMCs) is less elucidated. Here, we present evidence that PTH promotes apoptosis of VSMCs and endoplasmic reticulum (ER) stress participates in this process. Human aorta vascular smooth mus...
Source: Renal Failure - February 17, 2022 Category: Urology & Nephrology Authors: Shuzhong Duan Xinpan Chen Yingjie Liu Weikang Guo Wenhu Liu Source Type: research
Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury
CONCLUSION: SDP protected renal tubular epithelial cells from cell pyroptosis and EMT by regulating the albumin-induced mitochondrial dysfunction/ MAVS/ NLRP3-ASC-caspase-1 inflammasome signaling pathway.PMID:34908861 | PMC:PMC8665879 | DOI:10.2147/JIR.S341598
Source: Cell Research - December 15, 2021 Category: Cytology Authors: Yiye Zhu Guoshun Huang Yang Yang Chen Yong Xiang Yu Gang Wang Lan Yi Kun Gao Fang Tian Shushu Qian Enchao Zhou Yanqin Zou Source Type: research
ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte
CONCLUSIONS: ATF4 induces autophagy by enhancing the expression of HO-1, and inhibits podocyte apoptosis in DN. Treatment with the HO-1 agonist reduced proteinuria, apoptosis, and enhanced autophagy response, and thus improved renal function in DN mice.PMID:34157937 | DOI:10.1080/0886022X.2021.1936040
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Shizhu Yuan Xudong Liang Wenfang He Mingzhu Liang Juan Jin Qiang He Source Type: research
Autophagosome protects proximal tubular cells from aldosterone-induced senescence through improving oxidative stress
Ren Fail. 2021 Dec;43(1):556-565. doi: 10.1080/0886022X.2021.1902821.ABSTRACTAldosterone exerts an enormous function on proximal tubular cells (PTC) senescence, which is a common pathomechanism contributing to renal dysfunction. Numerous studies have shown that oxidative stress is deeply involved in the pathophysiologic processes of chronic kidney diseases. The study aims to investigate whether autophagy could regulate the process of senescence through oxidative stress in PTC both in vivo and ex vivo. Our results suggested that aldosterone treatment increased the senescence and oxidative stress as evidenced by increased pe...
Source: Renal Failure - March 24, 2021 Category: Urology & Nephrology Authors: Jing-Yuan Cao Li-Lu Ling Wei-Jie Ni Hong-Lei Guo Min Yang Source Type: research
