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Condition: Renal Failure
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Total 60 results found since Jan 2013.
Oxidative stress and inflammation are mediated via aryl hydrocarbon receptor signalling in idiopathic membranous nephropathy
Free Radic Biol Med. 2023 Jul 12:S0891-5849(23)00543-9. doi: 10.1016/j.freeradbiomed.2023.07.014. Online ahead of print.ABSTRACTMembranous nephropathy (MN) patients are diagnosed by the presence of phospholipase A2 receptor (PLA2R) before they progress to renal failure. However, the subepithelium-like immunocomplex deposit-mediated downstream molecular pathways are poorly understood. The aryl hydrocarbon receptor (AHR), NF-ƙB and Nrf2 pathways play central roles in the pathogenesis and progression of chronic kidney disease. However, their mutual effects on MN require further examination. Thus, we investigated the effect o...
Source: Free Radical Biology and Medicine - July 14, 2023 Category: Biology Authors: Yan-Ni Wang Hua Miao Xiao-Yong Yu Yan Guo Wei Su Fei Liu Gang Cao Ying-Yong Zhao Source Type: research
Transient receptor potential canonical 6 knockdown ameliorated diabetic kidney disease by inhibiting nuclear factor of activated T cells 2 expression in glomerular mesangial cells
CONCLUSION: These results demonstrate that inhibition of TRPC6/NFAT2 signaling attenuates GMC dysfunction and the development of DKD and suggest that pharmacological targeting of TRPC6/NFAT2 in GMCs may provide beneficial effects for DKD.PMID:36285371 | DOI:10.1080/0886022X.2022.2134796
Source: Renal Failure - October 26, 2022 Category: Urology & Nephrology Authors: Jian Yu Chunchun Li Lisha Ma Bin Zhai Aiping Xu Decui Shao Source Type: research
Angiotensin II type 2 receptor prevents extracellular matrix accumulation in human peritoneal mesothelial cell by ameliorating lipid disorder via LOX-1 suppression
Ren Fail. 2022 Dec;44(1):1687-1697. doi: 10.1080/0886022X.2022.2133729.ABSTRACTEvidence suggests that intracellular angiotensin II type 1 receptor (AT1) contributes to peritoneal fibrosis (PF) under high glucose (HG)-based dialysates. It is generally believed that AT2 antagonisticly affects AT1 function. The aim of this study was to explore whether AT2 activation is beneficial for attenuating human peritoneal mesothelial cell (HPMC) injury due to HG. We treated a HPMC line with HG to induce extracellular matrix (ECM) formation. AT2 was increased and blocked using CGP42112A and AT2 siRNA. Lipid deposition was detected, sign...
Source: Renal Failure - October 13, 2022 Category: Urology & Nephrology Authors: Jing Liu Bo Jin Jian Lu Yuan Feng Nan Li Cheng Wan Qing-Yan Zhang Chun-Ming Jiang Source Type: research
Cyclophilin A/CD147 signaling induces the epithelial-to-mesenchymal transition and renal fibrosis in chronic allograft dysfunction by regulating p38 MAPK signaling
CONCLUSIONS: Our study reported the positive relationship of CyPA-CD147 signaling with renal allograft dysfunction. The in vitro study suggested that CyPA-CD147 signaling induce the development of the EMT process by p38 MAPK signaling, thus contributing to renal allograft fibrosis and CAD.PMID:36203223 | DOI:10.1080/0886022X.2022.2126788
Source: Renal Failure - October 6, 2022 Category: Urology & Nephrology Authors: Xuzhong Liu Zhiwang Tang Xi Jiang Tianwei Wang Lun Zhao Zongyuan Xu Kun Liu Source Type: research
Vitamin D/vitamin D receptor/Atg16L1 axis maintains podocyte autophagy and survival in diabetic kidney disease
CONCLUSION: Autophagy protects podocytes from damage in DN and is modulated by VitD3/VDR signaling and downstream regulation of Atg16L1 expression.PMID:35469547 | DOI:10.1080/0886022X.2022.2063744
Source: Renal Failure - April 26, 2022 Category: Urology & Nephrology Authors: Lang Shi Chao Xiao Yafei Zhang Yao Xia Hongchu Zha Jiefu Zhu Zhixia Song Source Type: research
MicroRNA-17-5p promotes vascular calcification by targeting ANKH
CONCLUSION: Our data showed that miR-17-5p may promote vascular calcification by inhibiting ANKH expression.PMID:35297350 | DOI:10.2174/1567202619666220316115425
Source: Current Neurovascular Research - March 17, 2022 Category: Neurology Authors: Chao Shi Jiaorong Tan Jiancan Lu Junling Huang Xiangqi Li Jiahong Xu Xing Wang Source Type: research
