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Condition: Renal Failure
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Total 35 results found since Jan 2013.
Transient receptor potential canonical 6 knockdown ameliorated diabetic kidney disease by inhibiting nuclear factor of activated T cells 2 expression in glomerular mesangial cells
CONCLUSION: These results demonstrate that inhibition of TRPC6/NFAT2 signaling attenuates GMC dysfunction and the development of DKD and suggest that pharmacological targeting of TRPC6/NFAT2 in GMCs may provide beneficial effects for DKD.PMID:36285371 | DOI:10.1080/0886022X.2022.2134796
Source: Renal Failure - October 26, 2022 Category: Urology & Nephrology Authors: Jian Yu Chunchun Li Lisha Ma Bin Zhai Aiping Xu Decui Shao Source Type: research
Angiotensin II type 2 receptor prevents extracellular matrix accumulation in human peritoneal mesothelial cell by ameliorating lipid disorder via LOX-1 suppression
Ren Fail. 2022 Dec;44(1):1687-1697. doi: 10.1080/0886022X.2022.2133729.ABSTRACTEvidence suggests that intracellular angiotensin II type 1 receptor (AT1) contributes to peritoneal fibrosis (PF) under high glucose (HG)-based dialysates. It is generally believed that AT2 antagonisticly affects AT1 function. The aim of this study was to explore whether AT2 activation is beneficial for attenuating human peritoneal mesothelial cell (HPMC) injury due to HG. We treated a HPMC line with HG to induce extracellular matrix (ECM) formation. AT2 was increased and blocked using CGP42112A and AT2 siRNA. Lipid deposition was detected, sign...
Source: Renal Failure - October 13, 2022 Category: Urology & Nephrology Authors: Jing Liu Bo Jin Jian Lu Yuan Feng Nan Li Cheng Wan Qing-Yan Zhang Chun-Ming Jiang Source Type: research
Cyclophilin A/CD147 signaling induces the epithelial-to-mesenchymal transition and renal fibrosis in chronic allograft dysfunction by regulating p38 MAPK signaling
CONCLUSIONS: Our study reported the positive relationship of CyPA-CD147 signaling with renal allograft dysfunction. The in vitro study suggested that CyPA-CD147 signaling induce the development of the EMT process by p38 MAPK signaling, thus contributing to renal allograft fibrosis and CAD.PMID:36203223 | DOI:10.1080/0886022X.2022.2126788
Source: Renal Failure - October 6, 2022 Category: Urology & Nephrology Authors: Xuzhong Liu Zhiwang Tang Xi Jiang Tianwei Wang Lun Zhao Zongyuan Xu Kun Liu Source Type: research
MicroRNA-17-5p promotes vascular calcification by targeting ANKH
CONCLUSION: Our data showed that miR-17-5p may promote vascular calcification by inhibiting ANKH expression.PMID:35297350 | DOI:10.2174/1567202619666220316115425
Source: Current Neurovascular Research - March 17, 2022 Category: Neurology Authors: Chao Shi Jiaorong Tan Jiancan Lu Junling Huang Xiangqi Li Jiahong Xu Xing Wang Source Type: research
Autophagosome protects proximal tubular cells from aldosterone-induced senescence through improving oxidative stress
Ren Fail. 2021 Dec;43(1):556-565. doi: 10.1080/0886022X.2021.1902821.ABSTRACTAldosterone exerts an enormous function on proximal tubular cells (PTC) senescence, which is a common pathomechanism contributing to renal dysfunction. Numerous studies have shown that oxidative stress is deeply involved in the pathophysiologic processes of chronic kidney diseases. The study aims to investigate whether autophagy could regulate the process of senescence through oxidative stress in PTC both in vivo and ex vivo. Our results suggested that aldosterone treatment increased the senescence and oxidative stress as evidenced by increased pe...
Source: Renal Failure - March 24, 2021 Category: Urology & Nephrology Authors: Jing-Yuan Cao Li-Lu Ling Wei-Jie Ni Hong-Lei Guo Min Yang Source Type: research
