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Specialty: Biochemistry
Condition: Fatty Liver Disease (FLD)
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Total 21 results found since Jan 2013.
Gut microbiota metabolite TMAO promoted lipid deposition and fibrosis process via KRT17 in fatty liver cells in vitro
In conclusion, the gut microbiota metabolite TMAO could promote lipid deposition and fibrosis process via the KRT17 gene in fatty liver cells in vitro.PMID:37271025 | DOI:10.1016/j.bbrc.2023.05.041
Source: Biochemical and Biophysical Research communications - June 4, 2023 Category: Biochemistry Authors: Fulin Nian Chen Zhu Nuyun Jin Qiaoyun Xia Longyun Wu Xiaolan Lu Source Type: research
Oroxylin-A alleviates hepatic lipid accumulation and apoptosis under hyperlipidemic conditions via AMPK/FGF21 signaling
In conclusion, OA improves inflammation through the AMPK/FGF21 pathway, thereby attenuating lipid accumulation and apoptosis in hepatocytes. This study may help identify new targets for developing treatments for NAFLD.PMID:36736092 | DOI:10.1016/j.bbrc.2023.01.090
Source: Biochemical and Biophysical Research communications - February 3, 2023 Category: Biochemistry Authors: Wonjun Cho Sung Woo Choi Heeseung Oh A M Abd El-Aty Ahmet Hacimuftuoglu Ji Hoon Jeong Jin-Ho Song Yong Kyoo Shin Tae Woo Jung Source Type: research
Abietic acid alleviates endoplasmic reticulum stress and lipid accumulation in human primary hepatocytes through the AMPK/ORP150 signaling
This study investigated the impacts of AA on ER stress and steatosis in in vitro obesity models. We found that Treatment with AA reduced lipid deposition and lipogenesis-related proteins expression in human primary hepatocytes. Augmented expression of ER stress markers (phospho-eukaryotic initiation factor-2α (eIF2α) and C/EBP homologous protein (CHOP)) in palmitate-treated hepatocytes were reversed by AA treatment. Further, AA treatment increased the expression of phospho-AMPK and oxygen-regulated protein 150 (ORP150) in hepatocytes. siRNA-associated knockdown of AMPK or ORP150 expression reduced the effects of AA on no...
Source: Biochemical and Biophysical Research communications - April 10, 2022 Category: Biochemistry Authors: Tae Woo Jung Ju-Cheol Jeong Seung Yeon Park Wonjun Cho Heeseung Oh Hyun Jung Lee Ahmet Hacimuftuoglu A M Abd El-Aty Joon Seok Bang Ji Hoon Jeong Source Type: research
Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes
This study is the first to describe Nudt19 as regulator of hepatic lipid metabolism and potential mediator of NAFLD and T2D development.PMID:35367353 | DOI:10.1016/j.bbalip.2022.159153
Source: Biochimica et Biophysica Acta - April 3, 2022 Category: Biochemistry Authors: Sarah G örigk D Margriet Ouwens Tanja Kuhn Delsi Altenhofen Christian Binsch Mareike Damen Jenny Minh-An Khuong Katharina Kaiser Birgit Knebel Heike Vogel Annette Sch ürmann Alexandra Chadt Hadi Al-Hasani Source Type: research
Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine
Conclusion, high fat and TMA could induce the expression of FMO1 and its metabolite TMAO. When FMO1 is silenced, the effects of high fat and TMA on TMAO are blocked. And the role of TMAO in NAFLD may be through the activation of UPR.PMID:35065293 | DOI:10.1016/j.bbrc.2022.01.060
Source: Biochemical and Biophysical Research communications - January 22, 2022 Category: Biochemistry Authors: Chunxia Shi Maohua Pei Yao Wang Qian Chen Pan Cao Luyi Zhang Jin Guo Wei Deng Luwen Wang Xun Li Zuojiong Gong Source Type: research
Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes
In conclusion, Grp75 or Mfn2 silencing and overexpression in Huh7 cells contribute to altering MAM integrity and cholesterol storage in opposite directions, but all promote triglyceride accumulation through distinct cellular pathways. This study also highlights that besides Mfn2, Grp75 could play a central role in hepatic lipid and cholesterol metabolism in obesity and NAFLD.PMID:34419589 | DOI:10.1016/j.bbalip.2021.159030
Source: Biochimica et Biophysica Acta - August 22, 2021 Category: Biochemistry Authors: Arthur Bassot Carina Prip Buus Ana ïs Alves Olivier Berdeaux Johan Perrier V éronique Lenoir Jingwei Ji-Cao Marie-Agn ès Berger Emmanuelle Loizon Stephanie Cabaret Baptiste Panthu Jennifer Rieusset B éatrice Morio Source Type: research
miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.
CONCLUSIONS: Our results support the existence of a link between the liver cell mitochondria and miR-34a/SIRT1 signaling. Potential endogenous modulators of NAFLD pathogenesis may ultimately provide new tools for therapeutic intervention.
PMID: 33098868 [PubMed - as supplied by publisher]
Source: Archives of Biochemistry and Biophysics - October 21, 2020 Category: Biochemistry Authors: Wang L, Sun M, Cao Y, Ma L, Shen Y, Velikanova AA, Li X, Sun C, Zhao Y Tags: Arch Biochem Biophys Source Type: research
Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway.
This study aim was to investigate effects of HN on lipid accumulation in the hepatocytes and insulin signaling, and explore the underlying mechanisms. Protein expression levels were analyzed by Western blotting. Hepatic lipid accumulation was confirmed by Oil red-O staining. We found that HN-treatment ameliorated palmitate-induced lipid accumulation, expression of lipogenesis-associated genes (processed SREBP1, FAS, and SCD1), cell death, and caspase 3 activity in hepatocytes in a dose-dependent manner. Additionally, HN attenuated palmitate-induced impairment of insulin signaling. HN enhanced AMPK phosphorylation, whereas ...
Source: Biochemical and Biophysical Research communications - March 30, 2020 Category: Biochemistry Authors: Kwon C, Sun JL, Jeong JH, Jung TW Tags: Biochem Biophys Res Commun Source Type: research
CYP3A suppression during diet-induced nonalcoholic fatty liver disease is independent of PXR regulation
Publication date: Available online 24 May 2019Source: Chemico-Biological InteractionsAuthor(s): Hang Zeng, Yiming Lin, Jiande Gong, Sisi Lin, Jianguo Gao, Chunxiao Li, Zemin Feng, Hong Zhang, Jie Zhang, Youming Li, Chaohui YuAbstractCytochrome P450 3A (CYP3A) activity is inhibited, and its expression is suppressed during many diseases, including nonalcoholic fatty liver disease (NAFLD). However, the mechanism is controversial. Here, we report that PXR may not take part in the downregulation of CYP3A during NAFLD. Hepatic CYP3A11 (major subtype of mouse CYP3A) mRNA and protein expression was significantly decreased in both ...
Source: Chemico Biological Interactions - May 25, 2019 Category: Biochemistry Source Type: research
CYP1A2 contributes to alcohol-induced abnormal lipid metabolism through the PTEN/AKT/SREBP-1c pathway.
In this study, we aimed to explore the role of CYP1A2 in lipid metabolism abnormalities induced by alcohol and to investigate the underlying mechanisms. L02 cells were treated with siRNA-CYP1A2 or fluvoxamine and then stimulated with 100 mM ethanol for 24 h. The levels of ALT and TGs in the siRNA-CYP1A2 and fluvoxamine groups were significantly lower than those in the normal control group after ethanol treatment, and the expression of SREBP-1c was decreased when CYP1A2 was inhibited, suggesting that CYP1A2 may contribute to alcohol-induced irregular lipid metabolism by regulating sterol regulatory element-binding prote...
Source: Biochemical and Biophysical Research communications - April 8, 2019 Category: Biochemistry Authors: Zhu Q, Huang C, Meng X, Li J Tags: Biochem Biophys Res Commun Source Type: research
NLRC4 inflammasome activation regulated by TNF- α promotes inflammatory responses in nonalcoholic fatty liver disease.
In this study, we used NLRC4-targeting siRNA and an NLRC4-encoding plasmid to demonstrate that the increases in IL-18 and IL-1β are mainly attributable to the activation of the NLR family CARD domain-containing protein 4 (NLRC4) inflammasome, which stimulates cellular pyroptosis. NLRC4 inflammasome activation is regulated by TNF-α and accompanies the translocation of NLRC4 from the cytoplasm into the mitochondria, but the specific mechanism is unclear. In summary, the increase in TNF-α during NAFLD promotes the activation of the NLRC4 inflammasome, which increases the production of IL-18 and IL-1β and triggers pyroptos...
Source: Biochemical and Biophysical Research communications - February 25, 2019 Category: Biochemistry Authors: Chen Y, Ma K Tags: Biochem Biophys Res Commun Source Type: research
ZNF300 stimulates fatty acid oxidation and alleviates hepatosteatosis through regulating PPAR{alpha}
ZNF300 plays an important role in the regulation of HBV-related hepatocellular carcinoma. However, little is known about the role of ZNF300 in lipid metabolism and NAFLD. In the present study, we observed that ZNF300 expression was markedly decreased in free fatty acid (FFA)-induced fatty liver. Overexpressed ZNF300 alleviated hepatic lipid accumulation, whereas knockdown of ZNF300 enhanced the FFA-induced lipid accumulation. Investigations of the underlying mechanisms revealed that ZNF300 directly binds to and regulates the PPARα expression, thus promoting fatty acid oxidation. Furthermore, bisulfite pyrosequencing ...
Source: Biochemical Journal - January 31, 2019 Category: Biochemistry Authors: Yan, F.-J., Wang, Y.-J., Yan, S.-R., Lu, J., Zheng, Y.-L. Tags: Research Articles Source Type: research
