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GSE242834 Gene expression profiling and the effect of HDAC9 in cisplatin resistance of esophageal squamous cell carcinoma
Series Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensEsophageal cancer is one of the most serious health problems globally because of its high incidence and mortality rate. Cisplatin(CDDP) is the primary treatment but limited by the drug resistance. However, the mechanism of cisplatin resistance remains unclear. Herein, the CDDP-resistant cell line TE-1/CDDP was established to compared with TE-1, the expression profiles of circRNAs were compared between TE-1/CDDP and TE-1 using microarray analysis, Histone deacetylase 9(HDAC9) was identified significantly up-regulated. Using siRNA and conducting cell funct...
Source: GEO: Gene Expression Omnibus - September 14, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research

GSE206845 Effect of depletion of USP36 on gene expression of ECA109 cells, esophageal squamous cell carcinoma cell line.
Contributors : Wenhao Zhang ; Xiaogang Zhao ; Jian ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of USP36 in the regulation of cell proliferation and escc progression, we established eca109 cell lines in which each target gene has been knocked down by siRNA.We then performed gene expression profiling analysis using data obtained from RNA-seq of 6 different cells at same time points.
Source: GEO: Gene Expression Omnibus - January 4, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE143803 SREBF1 coordinates with master transcription factors in regulating lipid metabolism and cancer-promoting pathways in squamous cell carcinoma
Contributors : Liyan Li ; Qian Yang ; Yanyi Jiang ; Wei Yang ; Yuan Jiang ; Masaharu Hazawa ; Bo Zhou ; Xiang Li ; Sigal Gery ; Lingwen Ding ; Allen S Ho ; Zachary S Zumsteg ; Mingrong Wang ; Yanbing Ding ; Stephen J Freedland ; Liyan Xu ; Enmin Li ; H P Koeffler ; Dechen LinSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe profiled esophageal squamous cell carcinorma (ESCC) cell lines with chromatin immunoprecipitation sequencing (ChIP-Seq). Mathematically modeling was performed to establish (super)-enhancers landsca...
Source: GEO: Gene Expression Omnibus - June 15, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE132813 Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma
Contributors : Jian Pan ; Tiago C Silva ; Nicole Gull ; Qian Yang ; Jasmine Plummer ; Stephanie Chen ; Kenji Daigo ; Takao Hamakubo ; Ling-Wen Ding ; Samuel J Klempner ; Benjamin P Berman ; H P Koeffler ; De-Chen LinSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensWe profiled fresh-frozen esophageal tumor and normal samples and cell lines with chromatin immunoprecipitation sequencing (ChIP-Seq). Mathematically modeling was performed to establish (super)-enhancers landscapes and inter-connected transcriptional ci...
Source: GEO: Gene Expression Omnibus - June 14, 2020 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research

GSE143822 Differentially expressed genes after siRNA transfection or gene knockdown in human cancer cell lines
Contributors : Naohiko Seki ; Reona OkadaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by specific gene silencing (via siRNAs or knockout) in human cancer, several cell lines (esophageal cancer and gastric cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - January 17, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE118966 Differentially expressed genes after siRNA transfection in human cancer cell lines TE8, 786-O, A498 and PANC1
Contributors : Naohiko Seki ; Yasutaka YamadaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (siRNAs and miRNAs) in human cancer, several cell lines (esophagus cancer, renal cell carcinoma and pancreatic cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - August 24, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE118642 ANXA10 induction by interaction with tumor-associated macrophages promotes the growth of esophageal squamous cell carcinoma
Contributors : Himiko Kodaira ; Hiroshi YokozakiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTumor-associated macrophages (TAMs) have important roles in the progression, angiogenesis and motility of various cancers. To study the effects of TAMs on the tumor microenvironment of ESCCs, we constructed an in vitro system for the differentiation of peripheral blood monocyte (PBMo)-derived macrophages into TAM-like PBMo-derived macrophages.We established a co-culture assay using a human ESCC cell line and TAM-like PBMo-derived macrophages and we performed a cDNA microarray analysis between monocultured and c...
Source: GEO: Gene Expression Omnibus - August 17, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE107008 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines IV
Contributors : Naohiko Seki ; Yasutaka YamadaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - November 17, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE93290 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines (A-498, 786-O, A549, TE-8, PANC-1, SW1990, PC3 and PC3M)
Contributors : Naohiko Seki ; Takayuki AraiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines ( renal cell carcinoma, lung adenocarcinoma, esophageal, pancreatic and prostate cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - January 8, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE82108 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines (III)
Contributors : Naohiko Seki ; Yusuke GotoSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer, tongue squamous cell carcinoma, hypopharyngeal squamous cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - June 3, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE77790 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines II
Contributors : Naohiko Seki ; Yusuke GotoSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer, bladder cancer, prostate cancer, renal cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - April 13, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE77132 MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells
Conclusion: These results highlight the importance of miR-193b in determining oesophageal cancer cell viability and demonstrate an enhancement of chemotoxicity that is independent of apoptosis induction.
Source: GEO: Gene Expression Omnibus - January 23, 2016 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research