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ZNF703 is Overexpressed in Papillary Thyroid Carcinoma Tissues and Mediates K1 Cell Proliferation.
Abstract Zinc finger protein 703 (ZNF703), a member of the NET family of transcription factors, has recently emerged as an important player in the development of several types of cancers, though its role in papillary thyroid cancer (PTC) has not been characterized. We investigated the expression of ZNF703, its association with the most common genetic mutation in PTC, BRAF V600E, and its potential use as a therapeutic target. Real-time PCR, immunohistochemical staining, and western blot analysis of ZNF703 expression were performed for 36 cases of PTC and corresponding normal thyroid tissues. ZNF703 mRNA and protein...
Source: Pathology Oncology Research - October 25, 2018 Category: Pathology Authors: Yang X, Liu G, Zang L, Li D, Yu F, Xiang X, Li W Tags: Pathol Oncol Res Source Type: research

Long Non-coding RNA Linc-ROR Is Upregulated in Papillary Thyroid Carcinoma
AbstractLong non-coding RNAs (lncRNAs) may contribute to carcinogenesis and tumor progression by regulating transcription and gene expression. The role of lncRNAs in the regulation of thyroid cancer progression is being extensively examined. Here, we analyzed three lncRNAs that were overexpressed in papillary thyroid carcinomas, long intergenic non-protein coding RNA, regulator of reprogramming (Linc-ROR, ROR) PVT1 oncogene (PVT1), and HOX transcript antisense intergenic RNA (HOTAIR) to determine their roles in thyroid tumor development and progression. ROR expression has not been previously examined in thyroid carcinomas....
Source: Endocrine Pathology - December 26, 2017 Category: Pathology Source Type: research

Neurotrophin Receptors TrkA, p75(NTR), and Sortilin are Increased and Targetable in Thyroid Cancer.
Abstract Neurotrophin receptors are emerging targets in oncology, but their clinicopathological significance in thyroid cancer is unclear. Here, the neurotrophin tyrosine receptor kinase TrkA (also called NTRK1), the common neurotrophin receptor p75(NTR), and the pro-neurotrophin receptor sortilin were analyzed by immunohistochemistry in a cohort of thyroid cancers (n=128), and compared with adenomas and normal thyroid tissues (n=62). TrkA was detected in 20% of thyroid cancers, compared with none of the benign samples (P = 0.0007). TrkA expression was independent of histological subtypes but associated with lymph...
Source: The American Journal of Pathology - October 13, 2017 Category: Pathology Authors: Faulkner S, Jobling P, Rowe C, Rodriguez-Oliveira S, Roselli S, Thorne R, Oldmeadow C, Attia J, Jiang CC, Zhang XD, Walker MM, Hondermarck H Tags: Am J Pathol Source Type: research

The Roles of the Epithelial-Mesenchymal Transition Marker PRRX1 and MicroRNA 146b-5p in Papillary Thyroid Carcinoma Progression.
Abstract Thyroid carcinoma is the most common endocrine malignancy, and papillary thyroid carcinoma represents the most common thyroid cancer. Papillary thyroid carcinomas that invade locally or metastasize are associated with a poor prognosis. We found that, during epithelial-mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1), papillary thyroid carcinoma cells acquired increased cancer stem cell-like features and the transcription factor paired-related homeobox protein 1 (PRX-1; alias PRRX1), a newly identified EMT inducer, was markedly up-regulated. miR-146b-5p was also transiently ...
Source: The American Journal of Pathology - June 16, 2014 Category: Pathology Authors: Hardin H, Guo Z, Shan W, Montemayor-Garcia C, Asioli S, Yu XM, Harrison AD, Chen H, Lloyd RV Tags: Am J Pathol Source Type: research

TPX2 Overexpression in Medullary Thyroid Carcinoma Mediates TT Cell Proliferation.
Abstract TPX2 (targeting protein for xenopus kinesin-like protein 2), a microtubule-associated protein, plays an important role in the formation of the mitotic spindle. Abnormal expression of TPX2 in various types of malignant tumors has been reported, but less is known for medullary thyroid cancer (MTC). We investigated the expression of TPX2 in human MTC tissues and its potential use as a therapeutic target. Immunohistochemical analysis of TPX2 expression was performed for 32 cases of MTC and 8 cases of normal thyroid. TPX2 expression was found to be significantly higher in MTC compared to normal thyroid tissues...
Source: Pathology Oncology Research - February 1, 2014 Category: Pathology Authors: Yang X, Liu G, Xiao H, Yu F, Xiang X, Lu Y, Li W, Liu X, Li S, Shi Y Tags: Pathol Oncol Res Source Type: research