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TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway
ConclusionMAZ silencing inhibited tumor progress of thyroid cancer cells, whereas this inhibitory effect was reversed by TBK1 overexpression.
Source: Immunity, Inflammation and Disease - March 14, 2023 Category: Allergy & Immunology Authors: Qiuli Jiang, Yingying Guan, Jingmei Zheng, Huadong Lu Tags: ORIGINAL ARTICLE Source Type: research

miR-369 inhibits Liver Cancer progression by targeting ZEB1 pathway and predicts the prognosis of HCC patients
Increasing evidences show that microRNAs (miRNAs) are involved in the regulation of tumorigenesis, progression, recurrence and drug resistance of hepatocellular carcinoma (HCC). miR-369 works as a tumor suppressor in both lung cancer and thyroid cancer. However, the potential biological function of miR-369 in HCC is unknown. Herein, we for first found that miR-369 expression was downregulated in HCC tissues and predicted the poor prognosis of HCC patients. Forced miR-369 expression inhibited the proliferation and metastasis of HCC cells in vitro and in vivo. Mechanically, bioinformatics and luciferase reporter analysis ide...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yuwei Dong, Fuxia Li, Junjun Wang, Jiangfeng Hu, Zhenghong Li, Yubei Gu, Yun Feng Tags: Research Paper Source Type: research

Cancers, Vol. 13, Pages 185: Prognostic Value and Function of KLF5 in Papillary Thyroid Cancer
Khawla S. Al-Kuraya The Krüppel-like factor 5 (KLF5), a zinc-finger transcriptional factor, is highly expressed in several solid tumors, but its role in PTC remains unclear. We investigated the expression of KLF5 protein in a large cohort of PTC patient samples and explored its functional role and mechanism in PTC cell lines in vitro and in vivo. KLF5 overexpression was observed in 65.1% of all PTC cases and it was significantly associated with aggressive clinico-pathological parameters and poor outcome. Given the significant association between KLF5 and HIF-1α overexpression in PTC patients,...
Source: Cancers - January 7, 2021 Category: Cancer & Oncology Authors: Poyil Pratheeshkumar Abdul K. Siraj Sasidharan Padmaja Divya Sandeep Kumar Parvathareddy Sarah Siraj Roxanne Diaz Rafia Begum Saif S. Al-Sobhi Fouad Al-Dayel Khawla S. Al-Kuraya Tags: Article Source Type: research

ZNF703 is Overexpressed in Papillary Thyroid Carcinoma Tissues and Mediates K1 Cell Proliferation.
Abstract Zinc finger protein 703 (ZNF703), a member of the NET family of transcription factors, has recently emerged as an important player in the development of several types of cancers, though its role in papillary thyroid cancer (PTC) has not been characterized. We investigated the expression of ZNF703, its association with the most common genetic mutation in PTC, BRAF V600E, and its potential use as a therapeutic target. Real-time PCR, immunohistochemical staining, and western blot analysis of ZNF703 expression were performed for 36 cases of PTC and corresponding normal thyroid tissues. ZNF703 mRNA and protein...
Source: Pathology Oncology Research - October 25, 2018 Category: Pathology Authors: Yang X, Liu G, Zang L, Li D, Yu F, Xiang X, Li W Tags: Pathol Oncol Res Source Type: research