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Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression
Conclusions MDSC are major players in the immunosuppressive scenario in cancer, thanks to their phenotype heterogeneity and critical interaction with several innate immune cells, thus representing a crucial target in oncology. Here we reviewed the interactions of MDSCs with NK cells. The contribution of key cytokines, chemokines and mediators active in this process have been discussed. We also described the contribution of MDSC on angiogenesis directly or indirectly through interactions with NK and immunosuppressive activities. A parallel of the cancer associated to the decidual counterpart of these cells is discussed, a...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research

Sc-36 * reciprocal interaction of pge2 and wnt signaling regulates cancer stem cells in glioblastoma
The concept of oncogene addiction presupposes that cancer cells require certain dominant oncogenic signals for growth and survival. A profound implication of this hypothesis is that antagonizing this crucial pathway should have significant effects on cancer cells, while sparing normal cells that are not similarly addicted. Clinically, the recognition of oncogenes to which a cancer is addicted could have profound resonance for targeted cancer therapy. The Wnt signaling pathway has recently been described to be constitutively activated in a subgroup of glioblastomas. Here, we performed a systematic review of high-throughput ...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Wu, M., Nusrat, L., Celebre, A., Bredel, M., Karamchandani, J., Morshead, C., Das, S. Tags: STEM CELLS Source Type: research