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Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-Cancer Effect of Cap-Translation Inhibitor 4EGI-1 in Human Glioma U87 Cells: Involvement of Mitochondrial Dysfunction and ER Stress
Conclusion: These data indicate that the use of inhibitors that directly target the translation initiation complex eIF4F could represent a potential novel approach for human glioma therapy.Cell Physiol Biochem 2016;40:1013-1028
Source: Cellular Physiology and Biochemistry - December 9, 2016 Category: Cytology Source Type: research

Sc-36 * reciprocal interaction of pge2 and wnt signaling regulates cancer stem cells in glioblastoma
The concept of oncogene addiction presupposes that cancer cells require certain dominant oncogenic signals for growth and survival. A profound implication of this hypothesis is that antagonizing this crucial pathway should have significant effects on cancer cells, while sparing normal cells that are not similarly addicted. Clinically, the recognition of oncogenes to which a cancer is addicted could have profound resonance for targeted cancer therapy. The Wnt signaling pathway has recently been described to be constitutively activated in a subgroup of glioblastomas. Here, we performed a systematic review of high-throughput ...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Wu, M., Nusrat, L., Celebre, A., Bredel, M., Karamchandani, J., Morshead, C., Das, S. Tags: STEM CELLS Source Type: research

Abstract 2952: Aberrant accumulation of 2-hydroxyglutarate in human breast cancer with myc activation
Metabolite addiction of tumors may represent an Achilles heel for cancer cells and an opportunity for therapeutic intervention. Recently, using an untargeted discovery approach and validation of key metabolites, we characterized the metabolomic profile of human breast tumors and uncovered intrinsic metabolite signatures in these tumors. Importantly, the oncometabolite, 2-hydroxyglutarate (2HG), accumulated in a subset of tumors and human breast cancer cell lines. 2HG reached millimolar concentrations comparable to those in isocitrate dehydrogenase (IDH)-mutant gliomas, despite the absence of IDH mutations. Instead, we disc...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Mishra, P. Tags: Molecular and Cellular Biology Source Type: research