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DCLK1 inhibition attenuates tumorigenesis and improves chemosensitivity in esophageal squamous cell carcinoma by inhibiting β-catenin/c-Myc signaling.
In this study, real-time PCR and western blot analysis confirmed significant upregulation of DCLK1 expression in human ESCC tissues and cell lines. CCK-8 assay showed that transfection with siRNA against DCLK1 (si-DCLK1) markedly inhibited cell proliferation and colony formation in the ESCC cell lines Eca109 and TE1. Transwell assay revealed that si-DCLK1 transfection inhibited the migratory and invasive capacities of Eca109 and TE1 cells. Moreover, si-DCLK1 increased the chemosensitivity of these cells to cisplatin, as indicated by inhibited cell viability and colony formation, and increased ROS and apoptosis in cisplatin...
Source: Pflugers Archiv : European Journal of Physiology - June 11, 2020 Category: Physiology Authors: Zhang L, Zhou S, Guo E, Chen X, Yang J, Li X Tags: Pflugers Arch Source Type: research

PCNA and GSK3 β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis.
PCNA and GSK3β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis. Neoplasma. 2019 Oct 09;: Authors: Liu XH, Tang DE, Dai Y, Gao XJ, Liu LX Abstract Glycogen synthase kinase beta (GSK3β) is considered as a promising target for lung cancer treatment and its inhibitor lithium chloride (LiCl) is widely regarded as having potent anti-proliferative and apoptosis-modulating activities. Proliferating cell nuclear antigen (PCNA), as an auxiliary protein for DNA polymerase delta which regulates DNA replication and repair, has been reported to play an important role in regulating a...
Source: Neoplasma - October 8, 2019 Category: Cancer & Oncology Authors: Liu XH, Tang DE, Dai Y, Gao XJ, Liu LX Tags: Neoplasma Source Type: research

β‑catenin signaling pathway regulates cisplatin resistance in lung adenocarcinoma cells by upregulating Bcl‑xl.
Authors: Zhang J, Liu J, Li H, Wang J Abstract The Wnt/β‑catenin signaling pathway has been reported to regulate cisplatin resistance in several types of cancer cell. The present study aimed to investigate the role and underlying mechanism of Wnt/β‑catenin signaling in cisplatin resistance of lung adenocarcinoma cells. Wild‑type and cisplatin‑resistant A549 human lung adenocarcinoma cells (A549/WT and A549/CDDP, respectively) were cultured in vitro and exposed to different cisplatin concentrations. Cells were incubated with 10 mM lithium chloride (LiCl) to activate β‑catenin signaling. Cell prolifera...
Source: Molecular Medicine Reports - February 12, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research