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Drug: Lithium

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Total 27 results found since Jan 2013.

Tumor protein p53-induced nuclear protein 2 modulates osteogenic differentiation of human adipose derived stem/stromal cells by activating Wnt/ β-catenin signaling.
Tumor protein p53-induced nuclear protein 2 modulates osteogenic differentiation of human adipose derived stem/stromal cells by activating Wnt/β-catenin signaling. Am J Transl Res. 2020;12(10):6853-6867 Authors: Dong S, Li J, Zhang X Abstract Human adipose derived stem/stromal cells (hASCs) are frequently used as seed cells in bone tissue engineering. These cells have good osteogenic properties in various in vivo and in vitro models. Tumor protein p53-induced nuclear protein 2 (TP53INP2) regulates apoptosis, autophagy, and cell differentiation. However, whether TP53INP2 regulates osteogenic differenti...
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research

DCLK1 inhibition attenuates tumorigenesis and improves chemosensitivity in esophageal squamous cell carcinoma by inhibiting β-catenin/c-Myc signaling.
In this study, real-time PCR and western blot analysis confirmed significant upregulation of DCLK1 expression in human ESCC tissues and cell lines. CCK-8 assay showed that transfection with siRNA against DCLK1 (si-DCLK1) markedly inhibited cell proliferation and colony formation in the ESCC cell lines Eca109 and TE1. Transwell assay revealed that si-DCLK1 transfection inhibited the migratory and invasive capacities of Eca109 and TE1 cells. Moreover, si-DCLK1 increased the chemosensitivity of these cells to cisplatin, as indicated by inhibited cell viability and colony formation, and increased ROS and apoptosis in cisplatin...
Source: Pflugers Archiv : European Journal of Physiology - June 11, 2020 Category: Physiology Authors: Zhang L, Zhou S, Guo E, Chen X, Yang J, Li X Tags: Pflugers Arch Source Type: research

PCNA and GSK3 β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis.
PCNA and GSK3β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis. Neoplasma. 2019 Oct 09;: Authors: Liu XH, Tang DE, Dai Y, Gao XJ, Liu LX Abstract Glycogen synthase kinase beta (GSK3β) is considered as a promising target for lung cancer treatment and its inhibitor lithium chloride (LiCl) is widely regarded as having potent anti-proliferative and apoptosis-modulating activities. Proliferating cell nuclear antigen (PCNA), as an auxiliary protein for DNA polymerase delta which regulates DNA replication and repair, has been reported to play an important role in regulating a...
Source: Neoplasma - October 8, 2019 Category: Cancer & Oncology Authors: Liu XH, Tang DE, Dai Y, Gao XJ, Liu LX Tags: Neoplasma Source Type: research

Downregulation of microRNA-200c-3p reduces damage of hippocampal neurons in epileptic rats by upregulating expression of RECK and inactivating the AKT signaling pathway.
CONCLUSION: Our study provides evidence that downregulation of miR-200c-3p reduces damage of hippocampal neurons in epileptic rats by upregulating RECK and inactivating the AKT signaling pathway. PMID: 31018114 [PubMed - indexed for MEDLINE]
Source: Chemico-Biological Interactions - June 28, 2019 Category: Molecular Biology Authors: Du Y, Chi X, An W Tags: Chem Biol Interact Source Type: research

Downregulation of microRNA-200c-3p reduces damage of hippocampal neurons in epileptic rats by upregulating expression of RECK and inactivating the AKT signaling pathway
ConclusionOur study provides evidence that downregulation of miR-200c-3p reduces damage of hippocampal neurons in epileptic rats by upregulating RECK and inactivating the AKT signaling pathway.Graphical abstract
Source: Chemico Biological Interactions - April 22, 2019 Category: Biochemistry Source Type: research

Inhibition of proliferation by knockdown of transmembrane (TMEM) 168 in glioblastoma cells via suppression of Wnt/beta-catenin pathway.
Authors: Xu J, Su Z, Ding Q, Shen L, Nie X, Pan X, Yan A, Yan R, Zhou Y, Li L, Lu B Abstract Human glioblastoma multiforme (GBM) accounts for the majority of human brain gliomas. Several TMEM proteins, such as TMEM 45A, TMEM 97, and TMEM 140, are implicated in human brain gliomas. However, the roles of TMEM168 in human GBM remained extremely poor. Herein, we found that mRNA levels of TMEM168 were overexpressed in GBM patients (n = 85) when compared with healthy people (n = 10), which was also supported by data from The Cancer Genome Atlas (TCGA). KaplanMeier analysis of Gene Expression Omnibus dataset GSE16011 sugg...
Source: Oncology Research - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Cancers, Vol. 11, Pages 466: Proteomic Analysis Implicates Vimentin in Glioblastoma Cell Migration
Lawler We previously showed lithium chloride (LiCl) and other inhibitors of glycogen synthase kinase-3 (GSK-3) including 6-bromo-indirubin-3-oxime (BIO), can block glioblastoma (GBM) cell migration. To investigate the mechanisms involved we used two-dimensional difference in-gel electrophoresis (2D-DIGE) and mass spectrometry to identify proteins altered after treatment of U251 GBM cells with 20 mM LiCl. Downregulation of the intermediate filament protein vimentin was the most significant change identified. Analysis of patient tumor samples revealed that vimentin is expressed abundantly in GBM, and is prognostic espec...
Source: Cancers - April 2, 2019 Category: Cancer & Oncology Authors: Michal O. Nowicki Josie L. Hayes E. Antonio Chiocca Sean E. Lawler Tags: Article Source Type: research

Glucocorticoid induces osteonecrosis of the femoral head in rats through GSK3 β-mediated osteoblast apoptosis.
CONCLUSION: Our findings suggest that GC induces ONFH in rats through GSK3β-mediated osteoblast apoptosis, with involvement of mitochondrial apoptotic pathway. PMID: 30827503 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - February 27, 2019 Category: Biochemistry Authors: Nie Z, Chen S, Peng H Tags: Biochem Biophys Res Commun Source Type: research

Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3{beta} signaling Cell Biology
Brain and muscle ARNT-like protein-1 (BMAL-1) is an important component of the cellular circadian clock. Proteins such as epidermal (EGF) or nerve growth factor (NGF) affect the cellular clock via extracellular signal–regulated kinases-1/2 (ERK-1/2) in NIH3T3 or neuronal stem cells, but no such data are available for the insulin-like growth factor-1 (IGF-1). The hypothalamus expresses receptors for all three growth factors, acts as a central circadian pacemaker, and releases hormones in a circadian fashion. However, little is known about growth factor–induced modulation of clock gene activity in hypothalamic cells. Her...
Source: Journal of Biological Chemistry - November 2, 2018 Category: Chemistry Authors: Andreas Breit, Laura Miek, Johann Schredelseker, Mirjam Geibel, Martha Merrow, Thomas Gudermann Tags: Signal Transduction Source Type: research

p38 MAPK is Crucial for Wnt1- and LiCl-Induced Epithelial Mesenchymal Transition
SummaryIdiopathic pulmonary fibrosis (IPF) is characterized by myofibroblast foci in lung parenchyma. Myofibroblasts are thought to originate from epithelial-to-mesenchymal transition (EMT). Wnt1 and lithium chloride (LiCl) induce EMT in alveolar epithelial cells (AECs), but the mechanisms are unclear. AECs were treated with Wnt1 and LiCl, respectively; morphological change and molecular changes of EMT, including E-cadherin, fibronectin, and vimentin, were observed. SB203580 was administrated to test the role of p38 МАРК signaling in EMT. Then AECs were treated with siRNAs targeting p38 МАРК to further test the eff...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - June 1, 2018 Category: Research Source Type: research

Inositol polyphosphates contribute to cellular circadian rhythms: Implications for understanding lithium's molecular mechanism.
We examined whether the signaling molecule inositol hexaphosphate (IP6) has effects on circadian rhythms. Using a bioluminescent reporter (Per2::luc) to measure circadian rhythms, we determined that IP6 increased rhythm amplitude and shortened period in NIH3T3 cells. The IP6 effect on amplitude was attenuated by selective siRNA knockdown of GSK3B and pharmacological blockade of AKT kinase. However, unlike lithium, IP6 did not induce serine-9 phosphorylation of GSK3B. The synthesis of IP6 involves the enzymes inositol polyphosphate multikinase (IPMK) and inositol pentakisphosphate 2-kinase (IPPK). Knockdown of Ippk had effe...
Source: Cellular Signalling - January 10, 2018 Category: Cytology Authors: Wei H, Landgraf D, Wang G, McCarthy MJ Tags: Cell Signal Source Type: research

Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.
Abstract Lithium, given to bipolar disorder patients, causes nephrogenic diabetes insipidus (Li-NDI), a urinary concentrating defect. Li-NDI is due to downregulation of principal cell AQP2 expression, which coincides with principal cell proliferation. The metabolic effect of lithium on principal cells, however, is unknown and investigated here. Earlier, we have shown that the carbonic anhydrase (CA) inhibitor acetazolamide attenuated Li-induced downregulation in mouse collecting duct (mpkCCD) cells. Of the eight CAs present in mpkCCD cells, siRNA and drug treatments showed that downregulation of CA9 and to some ex...
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Alsady M, de Groot T, Kortenoeven MLA, Carmone C, Neijman K, Bekkenkamp-Grovenstein M, Engelke U, Wevers R, Baumgarten R, Korstanje R, Deen PMT Tags: Am J Physiol Renal Physiol Source Type: research

Antifibrotic Actions of Peroxisome Proliferator-Activated Receptor γ Ligands in Corneal Fibroblasts Are Mediated by β-Catenin-Regulated Pathways.
Abstract Wound healing after corneal injury typically involves fibrosis, with transforming growth factor β1 (TGF-β1) as one of its strongest mediators. A class of small molecules-peroxisome proliferator-activated receptor γ (PPARγ) ligands-exert potent antifibrotic effects in the cornea by blocking phosphorylation of p38 mitogen-activated protein kinase (MAPK). However, why this blocks fibrosis remains unknown. Herein, we show that PPARγ ligands (rosiglitazone, troglitazone, and 15-deoxy-Δ12,14-prostaglandin J2) decrease levels of β-catenin. We also show that β-catenin siRNA and the Wingless and integratio...
Source: The American Journal of Pathology - June 10, 2017 Category: Pathology Authors: Jeon KI, Phipps RP, Sime PJ, Huxlin KR Tags: Am J Pathol Source Type: research

Tanshinone IIA increases aquaporins expression in human amniotic epithelial WISH cells by stimulating GSK-3 β phosphorylation
Conclusion Tanshinone IIA increases AQPs expression in WISH cells by stimulating p-GSK-3β. AQP8 responds to tanshinone IIA the most rapidly compared with AQP9, AQP1, and AQP3 in WISH cells.
Source: Clinica Chimica Acta - November 10, 2016 Category: Laboratory Medicine Source Type: research

Tanshinone IIA increases aquaporins expression in human amniotic epithelial WISH cells by stimulating GSK-3 β phosphorylation.
CONCLUSION: Tanshinone IIA increases AQPs expression in WISH cells by stimulating p-GSK-3β. AQP8 responds to tanshinone IIA the most rapidly compared with AQP9, AQP1, and AQP3 in WISH cells. PMID: 27840100 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - November 9, 2016 Category: Chemistry Authors: Hua Y, Ding S, Cheng H, Luo H, Zhu X Tags: Clin Chim Acta Source Type: research