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MsrB1 Promotes Proliferation and Invasion of Colorectal Cancer Cells via GSK-3 β/β-catenin Signaling Axis
In conclusion, the oncogenic role and related mechanisms of MsrB1 in CRC discovered in our work determined the potential role of MsrB1 as a biomarker and may provide a new target for clinical therapy of CRC.PMID:34719306 | PMC:PMC8558597 | DOI:10.1177/09636897211053203
Source: Cell Transplantation - November 1, 2021 Category: Cytology Authors: Xiao-Yu Chen Sheng-Yong Yang Xiao-Jie Ruan Hong-Yue Ding Ning-Xi Wang Fang Liu Jia-Chu Li Yi Li Source Type: research

HOTAIR Promotes Cisplatin Resistance of Osteosarcoma Cells by Regulating Cell Proliferation, Invasion, and Apoptosis via miR-106a-5p/STAT3 Axis.
Abstract Osteosarcoma (OS) is a common primary malignant bone tumor among adolescences, and the emergence of multidrug resistance poses a huge challenge for clinical treatment of OS. LncRNA HOTAIR (HOX antisense intergenic RNA) has been reported to be associated with many malignancies, including OS. However, the underlying mechanisms of HOTAIR involved in drug resistance in OS are obscure. Our study showed that HOTAIR was upregulated in cisplatin (DDP)-resistant OS tissues and cells. HOTAIR knockdown decreased the DDP resistance, drug resistance-related gene expression, cell proliferation, and invasion and promote...
Source: Cell Transplantation - December 31, 2019 Category: Cytology Authors: Guo J, Dou D, Zhang T, Wang B Tags: Cell Transplant Source Type: research

The tetraspanin CD81 mediates the growth and metastases of human osteosarcoma
ConclusionBased on our findings we conclude that inhibition of CD81 suppresses intracellular signaling and reduces tumorigenesis and lung metastasis in osteosarcoma cells.
Source: Cellular Oncology - September 6, 2019 Category: Cancer & Oncology Source Type: research

Involvement of α5 integrin in survivin-mediated osteosarcoma metastasis
Conclusions Survivin-directed anti-tumor strategies might be an effective method in the treatment of osteosarcoma.
Source: Asian Pacific Journal of Tropical Medicine - March 22, 2016 Category: Tropical Medicine Source Type: research