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Specialty: Genetics & Stem Cells
Cancer: Skin Cancer
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Total 48 results found since Jan 2013.
GSE242834 Gene expression profiling and the effect of HDAC9 in cisplatin resistance of esophageal squamous cell carcinoma
Series Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensEsophageal cancer is one of the most serious health problems globally because of its high incidence and mortality rate. Cisplatin(CDDP) is the primary treatment but limited by the drug resistance. However, the mechanism of cisplatin resistance remains unclear. Herein, the CDDP-resistant cell line TE-1/CDDP was established to compared with TE-1, the expression profiles of circRNAs were compared between TE-1/CDDP and TE-1 using microarray analysis, Histone deacetylase 9(HDAC9) was identified significantly up-regulated. Using siRNA and conducting cell funct...
Source: GEO: Gene Expression Omnibus - September 14, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
GSE160638 MYC induces immunotherapy and interferon- γ resistance through downregulation of JAK2
Contributors : Ettai Markovits ; Ran Elkon ; Michal J Besser ; Gal MarkelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensImmunotherapy revolutionized the treatment of advanced melanoma. As the pathways mediating resistance to immunotherapy are largely unknown, we conducted transcriptome profiling of pre-immunotherapy tumor biopsies from melanoma patients that received PD-1 blockade (n=36) or adoptive cell therapy with tumor infiltrating lymphocytes (n=37). We identified two melanoma-intrinsic mutually exclusive gene programs, which are controlled by interferon- γ and MYC, and determi...
Source: GEO: Gene Expression Omnibus - April 24, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE146975 EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer
Contributors : Michael Rose ; Bernd Denecke ; Nadine T GaisaSeries Type : Expression profiling by arrayOrganism :Recent findings suggested a benefit of anti-EGFR therapy for basal-like muscle invasive bladder cancer (MIBC). However, impact on bladder cancer with substantial squamous differentiated (Sq-BLCA) and especially pure squamous cell carcinoma (SCC) remains unknown. Therefore, we comprehensively characterized pure and mixed Sq-BLCA (n=125) on genetic and protein expression level, and performed functional pathway and drug-response analyses with cell line models and isolated primary SCC (p-SCC) cells of the human urin...
Source: GEO: Gene Expression Omnibus - March 12, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research
GSE206845 Effect of depletion of USP36 on gene expression of ECA109 cells, esophageal squamous cell carcinoma cell line.
Contributors : Wenhao Zhang ; Xiaogang Zhao ; Jian ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of USP36 in the regulation of cell proliferation and escc progression, we established eca109 cell lines in which each target gene has been knocked down by siRNA.We then performed gene expression profiling analysis using data obtained from RNA-seq of 6 different cells at same time points.
Source: GEO: Gene Expression Omnibus - January 4, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE140966 RNA-Seq profiling of circular RNAs and the oncogenic role of circPVT1 in cutaneous squamous cell carcinoma
Contributors : Shuang Chen ; Chundi HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCircular RNAs(circRNAs),which are a type of non-coding RNA with a special structure, have attracted the attention of researchers in recent years.As a high throughput gene screening method, RNA-seq has been widely used in tumor research.In present study,we assessed the expression pattern of circRNAs in CSCC via RNA-seq on CSCC and matched paracancerous samples. We further identified circPVT1 as being overexpressed in CSCC tissues and cells.Subsequently, we identified the characteristics of circPVT1 in...
Source: GEO: Gene Expression Omnibus - November 24, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Gallic Acid has an inhibitory effect on skin squamous cell carcinoma and acts on the heat shock protein HSP90AB1
Gene. 2022 Nov 11:147041. doi: 10.1016/j.gene.2022.147041. Online ahead of print.ABSTRACTDifferences in the features of aggressiveness of non-melanoma skin cancer (NMSC) subtypes, between basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are relevant characteristics. Comparing the characteristics between NMSC subtypes might help identify molecules associated with cancer metastasis and invasion. Considering these facts, the current study aimed to identify a molecular target for inhibiting skin cancer metastasis and invasion. Proteomic analysis suggested that heat shock protein 90 kDa, alpha, class B member 1 (HSP...
Source: Gene - November 14, 2022 Category: Genetics & Stem Cells Authors: Sabrina Ferreira de Jesus Marcela Gon çalves de Souza Lorena Dos Reis Pereira Queiroz Daniela Paola Santos de Paula Angeliny Tamiarana Lima Tabosa Wislene Sarajane Moreira Alves Luiz Henrique da Silveira Andr é Teixeira da Silva Ferreira Ozires Jos é D Source Type: research
GSE161226 HEDGEHOG/GLI Modulates The PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas
Contributors : Yiyun Sun ; Ying ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe previously demonstrated that proline-rich protein 11 (PRR11) and spindle and kinetochore associated 2 (SKA2) constituted a head-to-head gene pair driven by a prototypical bidirectional promoter, and this gene pair synergistically promoted the development of non-small-cell lung cancer. However, the signaling pathways leading to the ectopic expression of this gene pair remain obscure. In the present study, we first analyzed the lung squamous cell carcinoma (LSCC) relevant RNA sequencing data from the...
Source: GEO: Gene Expression Omnibus - November 10, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE210922 FOXM1-mediated regulation of reactive oxygen species and radioresistance in oral squamous cell carcinoma cells
Contributors : Hisashi Takeshita ; Ryoji Yoshida ; Junki Inoue ; Mayumi Hirayama ; Toru Oyama ; Ryuta Kubo ; Keisuke Yamana ; Yuka Nagao ; Shunsuke Gohara ; Junki Sakata ; Masatoshi Hirayama ; Kenta Kawahara ; Nozomu Takahashi ; Akiyuki Hirosue ; Yoshikazu Kuwata ; Manabu Fukumoto ; Ryo Toya ; Ryuji Murakami ; Hideki NakayamaSeries Type : Expression profiling by arrayOrganism : Homo sapiensRadioresistance is a major obstacle to the successful treatment of oral squamous cell carcinoma (OSCC). To help overcome this issue, we have developed clinically relevant radioresistant (CRR) cell lines, generated by irradiating parental...
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE205981 RNA-Seq analysis of cSCC cells followed by siRNA-induced gene knockdown of lncRNA LINC00094 (SERLOC)
Contributors : Minna Piipponen ; Liisa Nissinen ; Veli-Matti K ähäriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKeratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and its incidence is increasing globally. Long non-coding RNAs (lncRNAs) are involved in various biological processes, and their role in cancer progression is emerging. Whole transcriptome analysis of cSCC cells (n=8) and normal human epidermal keratinocytes (NHEKs, n=4) revealed overexpression of long intergenic ncRNA (LINC00094) in cSCC cells (GSE66412). We wanted...
Source: GEO: Gene Expression Omnibus - August 29, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE174626 mRNA-Seq analysis of cSCC cells followed by siRNA-induced gene knockdown of C1r.
Contributors : Kristina Viiklepp ; Liisa Nissinen ; Veli-Matti K ähäriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKeratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and its incidence is increasing globally. Chronic inflammation has been recognized as a risk factor for cSCC and inflammation is a typical feature in the progression of premalignant actinic keratosis lesions to invasive and metastatic cSCC. The complement system is an important part of innate immunity, and activation of complement is detected in the microenvironme...
Source: GEO: Gene Expression Omnibus - November 17, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE131048 PERK signaling through C/EBP δ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells.
Contributors : Namratha Sheshadri ; Esta SterneckSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExpression of the transcription factor CEBPD is induced at early stages of the endoplasmic reticulum (ER) stress response. In order to identify the genes modulated by CEBPD during the ER stress response, we transiently silenced CEBPD expression in MDA-MB-435 melanoma cells and isolated mRNA at 6 h of treatment with Thapsigargin or DMSO control. As control, cells were transfected with two different control siRNA oligonucleotides. Results provide insights into which genes are modulated by CE...
Source: GEO: Gene Expression Omnibus - November 1, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE183926 Differentially expressed genes after transfection of siRNA in human cancer cell lines
Contributors : Naohiko Seki ; Kengo TanigawaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by siRNAs transfection in human cancer, lung squamous cell carcinoma cell lines were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - September 11, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE178669 Next Generation Sequencing Facilitates Quantitative Analysis of Control siRNA, RAB11A siRNA1 and RAB11A siRNA2 suppressed EBC-1 cell's Transcriptomes
This study aims to find cellular pathway changes in RAB11A suppressed in lung squamous cell carcinoma cell line EBC-1 compared to control and to evaluate downregulating genes by RAB11A suppression by siRNA. Total RNA was extracted from EBC-1 transfected with control siRNA and RAB11A specific siRNAs using the RNeasy mini kit (Qiagen, Hilden, Germany). CAGE library preparation, sequencing, mapping, and gene expression and motif discovery analysis were performed by DNAFORM (Yokohama, Japan). In brief, RNA quality was assessed by Bioanalyzer (Agilent) to ensure that RIN (RNA integrity number) is over 7.0 and A260/280 and 260/2...
Source: GEO: Gene Expression Omnibus - June 23, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE115791 Transcriptome of primary and metastatic human melanoma with silenced STAT3
Contributors : Bozena Kaminska ; Dorota W Kulesza ; Kavita Ramji ; Jakub MieczkowskiSeries Type : Expression profiling by arrayOrganism : Homo sapiensPrimary and metastatic human melanoma cells were transfected with control siRNA or siSTAT3 to silence its expression. The global gene expression was evaluated after 48 h and related to gene levels in cells transfected with siRNA control.
Source: GEO: Gene Expression Omnibus - June 14, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
