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Cancers, Vol. 12, Pages 1258: Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma
This study revealed for the first time the therapeutic potential of TNIK inhibition in synovial sarcoma.
Source: Cancers - May 15, 2020 Category: Cancer & Oncology Authors: Tetsuya Sekita Tesshi Yamada Eisuke Kobayashi Akihiko Yoshida Toru Hirozane Akira Kawai Yuko Uno Hideki Moriyama Masaaki Sawa Yuichi Nagakawa Akihiko Tsuchida Morio Matsumoto Masaya Nakamura Robert Nakayama Mari Masuda Tags: Article Source Type: research

1182PDA novel affinity-enhanced NY-ESO-1-targeting TCR-redirected T cell transfer exhibited early-onset cytokine release syndrome and subsequent tumour responses in synovial sarcoma patients
ConclusionsThe affinity-enhanced NY-ESO-1/TCR-T cell transfer exhibited early-onset CRS in association with in vivo cell proliferation and sequential tumor responses in the patients with high-NY-ESO-1-expressing synovial sarcoma.Clinical trial identificationNCT02366546.Legal entity responsible for the studyThe authors.FundingJapan Agency for Medical Research and Development.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy ‑dependent pathway in human synovial sarcoma cells.
Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy‑dependent pathway in human synovial sarcoma cells. Oncol Rep. 2018 Jul 25;: Authors: Zhu J, Cai Y, Xu K, Ren X, Sun J, Lu S, Chen J, Xu P Abstract Beclin1 is an important autophagy‑related prot-ein, which is involved in both autophagy and apoptosis. In recent years, the antitumor effect of Beclin1 has received increased attention. In the present study, we established a stable Beclin1‑overexpressing cell line with SW982 human synovial sarcoma cells. We found that Beclin1 overexpression decreased the cell viabi...
Source: Oncology Reports - August 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

EPHB4 tyrosine‐kinase receptor expression and biological significance in soft tissue sarcoma
Abstract Soft tissue sarcomas (STS) are heterogeneous malignant tumors of mesenchymal origin. Due to low incidence and high number of different histological subtypes, their pathogenesis and thus potential targets for their therapy remain barely investigated. Several studies revealed significant higher EPHB4 expression in malignancies such as prostate and colorectal cancer showing survival advantages for these tumor cells. Therefore we studied the expression of EPHB4 in a total of 46 clinical human specimens of different STS and human fibroblasts. EPHB4 mRNA and protein expression were significantly increased in synovial sa...
Source: International Journal of Cancer - October 1, 2014 Category: Cancer & Oncology Authors: M Becerikli, B Merwart, MC Lam, P Suppelna, A Rittig, A Mirmohammedsadegh, I Stricker, C Theiss, B.B. Singer, F Jacobsen, L Steinstraesser Tags: Carcinogenesis Source Type: research