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The oncolytic virus H101 combined with GNAQ siRNA ‐mediated knockdown reduces uveal melanoma cell viability
Journal of Cellular Biochemistry, EarlyView.
Source: Journal of Cellular Biochemistry - October 15, 2018 Category: Biochemistry Authors: Yongyun Li, Jie He, Chun Qiu, Qingfeng Shang, Guanxiang Qian, Xianqun Fan, Shengfang Ge, Renbing Jia Source Type: research

Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.
Abstract Uveal melanoma (UM) is the most common primary intraocular malignant tumor of adults. It has high mortality rate due to liver metastasis. However, the epidemiology and pathogenesis of liver metastasis in UM are not elucidated and there is no effective therapy available for preventing the development of this disease. IGF-1 is a growth factor involved in cell proliferation, malignant transformation and inhibition of apoptosis. In previous report, IGF-1 receptor was found to be highly expressed in UM and this was related to tumor prognosis. FoxO3a is a Forkhead box O (FOXO) transcription factor and a downstr...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 19, 2016 Category: Drugs & Pharmacology Authors: Yan F, Liao R, Farhan M, Wang T, Chen J, Wang Z, Little PJ, Zheng W Tags: Biomed Pharmacother Source Type: research

p21 is Responsible for Ionizing Radiation-induced Bypass of Mitosis
Conclusion Our results indicated that p21 was responsible for the downregulation of G2/M transition regulatory proteins and the bypass of mitosis induced by irradiation. Downregulation of p21 by siRNA resulted in G2-arrested cells entering into mitosis with serious DNA damage. This is the first report on elucidating the role of p21 in the bypass of mitosis.
Source: Biomedical and Environmental Sciences - August 30, 2016 Category: Biomedical Science Source Type: research

p21 is Responsible for Ionizing Radiation-induced Bypass of Mitosis.
CONCLUSION: Our results indicated that p21 was responsible for the downregulation of G2/M transition regulatory proteins and the bypass of mitosis induced by irradiation. Downregulation of p21 by siRNA resulted in G2-arrested cells entering into mitosis with serious DNA damage. This is the first report on elucidating the role of p21 in the bypass of mitosis. PMID: 27554118 [PubMed - in process]
Source: Biomedical and Environmental Sciences : BES - June 30, 2016 Category: Biomedical Science Authors: Zhang XR, Liu YA, Sun F, Li H, Lei SW, Wang JF Tags: Biomed Environ Sci Source Type: research

Abstract 2138: RasGRP3 mediates MAPK pathway activation in GNAQ mutant uveal melanoma
Uveal melanoma (UM) is the most common intraocular malignancy in adults and no effective treatment options are available for metastatic disease. Over 80% of UM show mutations in the Gαq family members GNAQ and GNA11. MAP-kinase pathway activation in part mediated by protein kinase C (PKC) has been shown as one critical contributing factor to GNAQ-mediated oncogenesis. However PKC inhibition alone does not completely suppress MAPK signaling. A more refined understanding of the signaling cascade linking MAPK signaling to mutant GNAQ or GNA11 is required to develop more effective strategies for targeted therapy. Among more t...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Chen, X., Wu, Q., Depeille, P., Roose, J. P., Bastian, B. C. Tags: Molecular and Cellular Biology Source Type: research

Detection of GNAQ mutations and reduction of cell viability in uveal melanoma cells with functionalized gold nanoparticles.
CONCLUSION: AuNPs may in future be developed to serve as sensors for mutations of vital importance. The new release system for siRNA-AuNP improves previous systems, which conceivably will be useful for future therapeutic gene regulatory approaches. PMID: 25653058 [PubMed - in process]
Source: Biomedical Microdevices - February 1, 2015 Category: Biomedical Engineering Authors: Posch C, Latorre A, Crosby MB, Celli A, Latorre A, Vujic I, Sanlorenzo M, Green GA, Weier J, Zekhtser M, Ma J, Monico G, Char DH, Jusufbegovic D, Rappersberger K, Somoza Á, Ortiz-Urda S Tags: Biomed Microdevices Source Type: research

Abstract 3334: The role of nuclear HER3 in breast cancer resistance
HER3 is reported to be overexpressed in 18-29% of human breast cancers and suggested to be a marker of reduced disease-specific survival in 4,406 patients with invasive breast carcinoma. Overexpression and subcellular localization of HER3 may be a negative predictive marker for targeted therapies, and HER3 status may play a role in the development of drug resistance and metastasis. Translocation of ERBB family members EGFR, HER2 and HER4 into nucleus for regulating gene transcription have been reported, but only a few studies about nuclear HER3 have been reported and the biological role of nuclear HER3 is still unknown. HE...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Tang, P. M. K., Khoo, U. S., Harris, A. L., Kong, A. Tags: Molecular and Cellular Biology Source Type: research

MicroRNA-124a Is Epigenetically Regulated and Acts as a Tumor Suppressor by Controlling Multiple Targets in Uveal Melanoma Biochemistry and Molecular Biology
Conclusions. Our results demonstrated that miR-124a could function as a potent tumor suppressor by regulation of multiple targets, and was epigenetically silenced in the development of uveal melanoma.
Source: Investigative Ophthalmology - March 27, 2013 Category: Opthalmology Authors: Chen, X., He, D., Dong, X. D., Dong, F., Wang, J., Wang, L., Tang, J., Hu, D.-N., Yan, D., Tu, L. Tags: Biochemistry and Molecular Biology Source Type: research

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