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Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) is upregulated in breast epithelial-mesenchymal transition and responds to oxidative stress
Mol Cell Proteomics. 2021 Dec 16:100185. doi: 10.1016/j.mcpro.2021.100185. Online ahead of print.ABSTRACTBreast cancer cells that have undergone partial epithelial-mesenchymal transition (EMT) are believed to be more invasive than cells that have completed EMT. To study metabolic reprogramming in different mesenchymal states, we analyzed protein expression following EMT in the breast epithelial cell model D492 with single-shot LFQ supported by a SILAC proteomics approach. The D492 EMT cell model contains three cell lines: the epithelial D492 cells, the mesenchymal D492M cells, and a partial mesenchymal, tumorigenic variant...
Source: Molecular and Cellular Proteomics : MCP - December 19, 2021 Category: Molecular Biology Authors: Qiong Wang Sigurdur Trausti Karvelsson Aristotelis Kotronoulas Thorarinn Gudjonsson Skarphedinn Halldorsson Ottar Rolfsson Source Type: research

HER3 PET Imaging Identifies Dynamic Changes in HER3 in Response to HER2 Inhibition with Lapatinib
CONCLUSION: HER3 PET imaging can be used to visualize dynamic changes in HER3 expression that occur in HER2+ breast cancers with HER2 inhibitor treatment and identify those likely to benefit by the addition of combination HER3 and HER2 inhibition.PMID:34101105 | DOI:10.1007/s11307-021-01619-8
Source: Mol Biol Cell - June 8, 2021 Category: Molecular Biology Authors: Eric Wehrenberg-Klee Nicoleta Sinevici Sarah Nesti Taylor Kalomeris Emily Austin Benjamin Larimer Umar Mahmood Source Type: research

Calcium based siRNA coating: a novel approach for knockdown of HER2 gene in MCF-7 cells using gold nanoparticles.
Authors: Sami A, Naqvi SMS, Qayyum M, Raza Rao A, Sabitaliyevich UY, Ahmad MS Abstract Surface functionalization of nanoparticles (NPs) for therapeutic siRNA delivery into cancer cells has gained interest. The present study was designed for surface functionalization of gold nanoparticles (AuNPs) for efficient siRNA delivery and knockdown in cancer cells. In order to achieve this objective, AuNPs were coated with HER2-siRNA in the presence of 11-mercaptoundecanoic acid (11-MUA), calcium chloride (CaCl2) and polyethyleneimine (PEI) in alternate charge bearing successive layers. MCF-7 cells were cultured and transfect...
Source: Cellular and Molecular Biology - October 14, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Neuropeptide bombesin receptor activation stimulates growth of lung cancer cells through HER3 with a MAPK-dependent mechanism
Publication date: Available online 17 December 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Lingaku Lee, Irene Ramos-Alvarez, Terry W. Moody, Samuel A. Mantey, Robert T. JensenAbstractDespite recent advances in treatment of non-small cell lung cancer (NSCLC), prognosis still remains poor and new therapeutic approaches are needed. Studies demonstrate the importance of the EGFR/HER-receptor family in NSCLC growth, as well as that of other tumors. Recently, HER3 is receiving increased attention because of its role in drug resistance and aggressive growth. Activation of overexpressed G-pr...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 18, 2019 Category: Molecular Biology Source Type: research

Erbb2 up‐regulation of ADAM12 expression accelerates skin cancer progression
Solar ultraviolet (UV) radiation can cause severe damage to the skin and is the primary cause of most skin cancer. UV radiation causes DNA damage leading to mutations and also activates the Erbb2/HER2 receptor through indirect mechanisms involving reactive oxygen species. We hypothesized that Erbb2 activation accelerates the malignant progression of UV‐induced skin cancer. Following the induction of benign squamous papillomas by UV exposure of v‐rasHa transgenic Tg.AC mice, mice were treated topically with the Erbb2 inhibitor AG825 and tumor progression monitored. AG825 treatment reduced tumor volume, increased tumor r...
Source: Molecular Carcinogenesis - May 5, 2014 Category: Molecular Biology Authors: Velidi H. Rao, Kristen Vogel, Jodi K. Yanagida, Nitin Marwaha, Amrit Kandel, Carol Trempus, Susan K. Repertinger, Laura A. Hansen Tags: Research Article Source Type: research

WNT10B/β‐catenin signalling induces HMGA2 and proliferation in metastatic triple‐negative breast cancer
Abstract Wnt/β‐catenin signalling has been suggested to be active in basal‐like breast cancer. However, in highly aggressive metastatic triple‐negative breast cancers (TNBC) the role of β‐catenin and the underlying mechanism(s) for the aggressiveness of TNBC remain unknown. We illustrate that WNT10B induces transcriptionally active β‐catenin in human TNBC and predicts survival‐outcome of patients with both TNBC and basal‐like tumours. We provide evidence that transgenic murine Wnt10b‐driven tumours are devoid of ERα, PR and HER2 expression and can model human TNBC. Importantly, HMGA2 is specifically exp...
Source: EMBO Molecular Medicine - January 11, 2013 Category: Molecular Biology Authors: Peter Wend, Stephanie Runke, Korinna Wend, Brenda Anchondo, Maria Yesayan, Meghan Jardon, Natalie Hardie, Christoph Loddenkemper, Ilya Ulasov, Maciej S. Lesniak, Rebecca Wolsky, Laurent A. Bentolila, Stephen G. Grant, David Elashoff, Stephan Lehr, Jean J. Tags: Research Article Source Type: research