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Specialty: Genetics & Stem Cells
Cancer: Gastric (Stomach) Cancer

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Total 23 results found since Jan 2013.

GSE209814 Gene expression profiles in gastric cancer cells with TM4SF1-AS1 knockdown
Contributors : Hiromu Suzuki ; Hiroshi KitajimaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo clarify the function of a long noncoding RNA TM4SF1-AS1 in gastric cancer (GC), we carried out a gene expression microarray analysis using GC cell lines HSC45 transfected with a siRNA targeting TM4SF1-AS1 or a control siRNA. Gene ontology analysis revealed that genes associated with interferon signaling and immune response were significantly enriched among downregulated genes.
Source: GEO: Gene Expression Omnibus - July 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE148795 Study of transcriptional effects of FOXS1 silencing and TGF-beta treatment in SNU-449 hepatocellular carcinoma cell line
Conclusions: FOXS1 is a novel TGFβ target and a key mediator of EMT. Its induction in cancer is associated with a poor prognosis. Thus, determining the exp ression of FOXS1 in advanced tumors in which the pro-metastatic arm of TGFβ is activated could help to identify patients who may benefit from targeted therapies using TGFβ inhibitors.
Source: GEO: Gene Expression Omnibus - June 15, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE196262 DUB1 suppresses Hippo signaling via modulating TAZ protein in gastric cancer
Contributors : Dehai Wang ; Yinlu Ding ; Jian Zhu ; Peng SuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe Hippo pathway functions as a tumor-suppressor pathway in human cancers, while the dys-function of Hippo pathway is frequently observed in malignancies. Although the YAP/TAZ activity is tightly controlled by the phosphorylation cascade of MST-LATS-YAP/TAZ axis, it is still unclear why YAP/TAZ protein is activated in human cancers, even Hippo pathway is still active. Besides phosphorylation, recent studies implicate that several post-translational modifications also play critic...
Source: GEO: Gene Expression Omnibus - February 12, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

KRT18 Modulates Alternative Splicing of Genes Involved in Proliferation and Apoptosis Processes in Both Gastric Cancer Cells and Clinical Samples
Keratin 18 (KRT18), one of the most abundant keratins in epithelial and endothelial cells, has been reported to be aberrantly expressed in many malignancies and extensively regarded as a biomarker and important regulator in multiple cancers, including gastric cancer (GC). But the molecular regulatory mechanisms of KRT18 in GC patients and cells are largely unknown. In the present study, we analyzed the expression level of KRT18 in 450 stomach adenocarcinoma tissue samples from TCGA database and found a significantly higher expression level in tumor tissues. We then explored the potential functions of KRT18 in AGS cells (hu...
Source: Frontiers in Genetics - July 5, 2021 Category: Genetics & Stem Cells Source Type: research

GSE163164 Gene expression profiling of AGS Gastric Cancer cells upon YY1 knock down
Contributors : B DIVYA ; G KUMARESANSeries Type : Expression profiling by arrayOrganism : Homo sapiensYin Yang 1 (YY1) is a ubiquitous transcription factor belonging to the GLI-Kruppel class of zinc finger proteins regulating diverse biological processes including cell proliferation, development, DNA damage responses and also involved in carcinogenesis. The protein is involved in repressing and activating a diverse number of promoters.In order to study the role of the transcription factor YY1 in gastric cancer, transcriptome wide gene expression analysis was performed upon silencing the YY1 gene in gastric cancer cell line...
Source: GEO: Gene Expression Omnibus - March 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE135085 Whole transcriptomes analyses of gastric cancer HGC-27 cell line treated with siSTRN3 mixture or negative control siRNA
Contributors : Yang Tang ; Shi JiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: To explore the molecular mechanisms of STRN3 regulating gastic cancer tumorigenesis, RNA sequencing was performed to analyze the geome-wide change of siSTRN3 treated HGC-27 cells compared to those of control cells.Methods: Total mRNA was extracted from HGC-27 cells in triplicate respectively. Then RNA quality was assessed using an Agilent Bioanalyzer 2100 and the sample reads were sequenced using Illumina Hiseq 4000 platform. As a reasult, we got the transcript data using Hisat2 followed by Str...
Source: GEO: Gene Expression Omnibus - June 5, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE143822 Differentially expressed genes after siRNA transfection or gene knockdown in human cancer cell lines
Contributors : Naohiko Seki ; Reona OkadaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by specific gene silencing (via siRNAs or knockout) in human cancer, several cell lines (esophageal cancer and gastric cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - January 17, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE121382 Transcriptome Analysis of CircMRPS35 mediated mRNA expression profiles
Contributors : Shiming Yang ; Changjiang HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: To explore the mechanism of circMRPS35-mediated suppression of proliferation and invasion in gastric cancer. Methods: MGC-803 cells were transfected with control and SiRNA-circMRPS35, in triplicate. Total RNA was extracted using Trizol reagent.
Source: GEO: Gene Expression Omnibus - November 1, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Overexpression of CASC11 in ovarian squamous cell carcinoma mediates the development of cancer cell resistance to chemotherapy.
Abstract LncRNA CASC11 promotes gastric cancer and colon cancer. Our study analyzed the role of CASC11 in ovarian squamous cell carcinoma (OSCC). In the present study we showed that plasma CASC11 was upregulated in OSCC, and the upregulation of CASC11 distinguished OSCC patients from control group. Plasma levels of CASC11 were further increased after chemotherapy. Treatment with oxaliplatin, tetraplatin, cisplatin, and carboplatin mediated the upregulation of CASC11 in cells of OSCC cell line. In addition, overexpression of CASC11 led to increased cancer cell viability under oxaliplatin, tetraplatin, cisplatin, an...
Source: Gene - June 6, 2019 Category: Genetics & Stem Cells Authors: Shen F, Feng L, Zhou J, Zhang H, Xu Y, Jiang R, Zhang H, Chen Y Tags: Gene Source Type: research

GSE125507 CRISPR-Cas9 screening of KSHV-transformed cells identifies XPO1 as a vulnerable target of cancer cells by inducing p62 SQSTM1-mediated p53 activation in PML bodies
Contributors : Marion Gruffaz ; Hongfeng Yuan ; Hui Liu ; Sangsu Bae ; Jin-Soo Kim ; Chun Lu ; Yufei Huang ; Shou-Jiang GaoSeries Type : OtherOrganism : Rattus norvegicusMislocalization of oncogenes and tumor suppressors resulting from aberrant nuclear export promotes uncontrolled cell proliferation and growth transformation of cancer cells. We performed a genome-wide CRISPR-Cas9 screening in matched primary and KSHV-transformed cells, and identified genes that were pro-growth and growth-suppressive of both types of cells, of which exportin XPO1 was a critical factor for the survival of transformed cells. Using XPO1 inhibi...
Source: GEO: Gene Expression Omnibus - May 21, 2019 Category: Genetics & Stem Cells Tags: Other Rattus norvegicus Source Type: research

Molecular Mechanisms in Clear Cell Renal Cell Carcinoma: Role of miRNAs and Hypermethylated miRNA Genes in Crucial Oncogenic Pathways and Processes
Eleonora A. Braga1*†, Marina V. Fridman2†, Vitaly I. Loginov1,3, Alexey A. Dmitriev4 and Sergey G. Morozov1 1Institute of General Pathology and Pathophysiology, Moscow, Russia 2Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia 3Research Center of Medical Genetics, Moscow, Russia 4Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia Clear cell renal cell carcinoma (ccRCC) is the third most common urological cancer, and it has the highest mortality rate. The increasing drug resistance of metastatic ccRCC has resulted in the search f...
Source: Frontiers in Genetics - April 23, 2019 Category: Genetics & Stem Cells Source Type: research

GSE130071 Vestigial-like 1 promotes malignancy in gastric cancer by PI3K/AKT/ β-catenin and TGF-β/ERK/RSK2 axes
Contributor : Bo K KimSeries Type : Expression profiling by arrayOrganism : Homo sapiensVGLL1 is involved in the regulation of proliferation and metastasis in gastric cancer cells and in vivo mouse models. To understand the downstream regulation of VGLL1, we conducted a microarray analysis of VGLL1 siRNA-treated NUGC3 cells.
Source: GEO: Gene Expression Omnibus - April 20, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Ajuba overexpression regulates mitochondrial potential and glucose uptake through YAP/Bcl-xL/GLUT1 in human gastric cancer.
Abstract Ajuba dysregulation has been reported in several human cancers. However, its expression patterns and biological roles in human gastric cancers have not yet been characterized. In the current study, we found that Ajuba protein was increased in gastric cancer tissues and in cell lines. High Ajuba expression positively correlated with the tumor-node-metastasis (TNM) stage, lymph node metastasis and poor prognosis. The Cancer Genome Atlas (TCGA) and Oncomine microarray data mining also suggested that Ajuba mRNA upregulation in gastric cancer tissues. We used SGC-7901 and NCI-N87 cell lines for Ajuba overexpre...
Source: Gene - January 25, 2019 Category: Genetics & Stem Cells Authors: Li H, Fu L, Liu B, Lin X, Dong Q, Wang E Tags: Gene Source Type: research

LncRNA GACAT3 acts as a competing endogenous RNA of HMGA1 and alleviates cucurbitacin B-induced apoptosis of gastric cancer cells.
In this study, we demonstrate that GACAT3 acts as a competing endogenous RNA of high mobility group A1 (HMGA1), a typical oncogene that is overexpressed in most types of cancer, based on a search for common miRNA-binding sites and on experiments involving in vitro cell transfection with synthesized miRNA mimics. Furthermore, knockdown of GACAT3 by its specific siRNA resulted in significantly decreased cell proliferation in gastric cancer cells, similar to the effect of an HMGA1 knockdown. Moreover, GACAT3 overexpression alleviated the apoptosis induced by cucurbitacin B, which is a widely used anticancer drug. Mechanistica...
Source: Gene - August 8, 2018 Category: Genetics & Stem Cells Authors: Lin Y, Li J, Ye S, Chen J, Zhang Y, Wang L, Xi Y, Bu S, Qiu X Tags: Gene Source Type: research

GSE102112 RNAseq analyze global transcriptome of changes between siIRF3 and siYAP in Gastric cancer cells
Contributors : Shi Jiao ; Jingmin GuanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: To investigate the signal crosstalk between IRF3 and YAP, RNA-sequencing (RNA-seq) was performed to analyze the genome-wide changes by the knockdown of IRF3 or YAP in HGC-27 cells.Methods: Total RNA was extracted from HGC-27 cell after transfection with negative control siRNA (n.c.), IRF3 siRNA (siIRF3) or YAP siRNA (siYAP). Then total RNA was quality controlled and quantified using an Agilent 2100 Bioanalyzer. After converting to cDNA and building library, high-throughput sequencing was per...
Source: GEO: Gene Expression Omnibus - August 1, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research