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Total 22168 results found since Jan 2013.

Improve Your Search Skills with Google Search Education
Google recently launched a website with resources teachers and librarians can use to improve student search strategy. The Google Search Education site includes many tools to help improve student search strategy and search results using the Google Search Engine. Lesson plans with practice search questions and activities are provided. For those who are interested in live demonstrations of the search techniques the Live Training area includes videos with sample searches and discussions. While Google Search Eduction was developed for improving student search strategy there are a variety of tools librarians and other educators...
Source: Network News - January 23, 2013 Category: Databases & Libraries Authors: Emily Hurst Tags: General (all entries) Technology Source Type: news

The Search for the Elusive Elixir of Life
By TOM EMERICK Here’s the executive summary: Most disease and health spending is age-related. As we age we get infirmities ranging from dementia to cancer to vascular disease. Nothing can prevent aging. Period. For millennia mankind has been been on a futile search to prevent aging. Search for the Elusive Elixir of Life For 3500 or more years mankind has been searching for the mythological Elixir of Life, the fountain of youth, the philosophers stone, pool of nectar, etc, that will defeat aging and extend life, if not achieve immortality. According to Wiki, “The elixir of life, also known as the elixir of immortality a...
Source: The Health Care Blog - February 4, 2016 Category: Consumer Health News Authors: Simon Nath Tags: THCB Tom Emerick Source Type: blogs

Current preclinical small interfering RNA (siRNA)-based conjugate systems for RNA therapeutics.
Abstract Recent promising clinical results of RNA therapeutics have drawn big attention of academia and industries to RNA therapeutics and their carrier systems. To improve their feasibility in clinics, systemic evaluations of currently available carrier systems under clinical trials and preclinical studies are needed. In this review, we focus on recent noticeable preclinical studies and clinical results regarding siRNA-based conjugates for clinical translations. Advantages and drawbacks of siRNA-based conjugates are discussed, compared to particle-based delivery systems. Then, representative siRNA-based conjugate...
Source: Advanced Drug Delivery Reviews - October 27, 2015 Category: Drugs & Pharmacology Authors: Lee SH, Kang YY, Jang HE, Mok H Tags: Adv Drug Deliv Rev Source Type: research

REGULATION OF OVULATORY GENES IN BOVINE GRANULOSA CELLS: LESSONS FROM siRNA SILENCING OF PTGS2.
Abstract Prostaglandin endoperoxide synthase 2 (PTGS2), tumor necrosis factor-alpha-induced protein-6 (TNFAIP6), pentraxin-3 (PTX3), epidermal growth factor like factors: amphiregulin (AREG) and epiregulin (EREG) are essential for successful ovulation. We compared here the induction of these ovulatory genes in bovine granulosa cells (GCs) in vivo (after LH surge) and in vitro (forskolin treatment). These genes were markedly stimulated in GCs isolated from cows 21hr after LH- surge. In isolated GCs, forskolin induced a distinct temporal profile for each gene. Generally, there was a good agreement between the in viv...
Source: Reproduction - October 16, 2014 Category: Reproduction Medicine Authors: Shrestha K, Lukasik K, Baufeld A, Vanselow J, Moallem U, Meidan R Tags: Reproduction Source Type: research

Next Phase of NIH Preprint Pilot Launching Soon
Last month, the National Library of Medicine (NLM)announced plans to extend its NIH Preprint Pilot in PubMed Central (PMC) and PubMed beyond COVID-19 to encompass all preprints reporting on NIH-funded research. The second phase of the pilot, launching later this month, will include preprints supported by an NIH award, contract, or intramural program and posted to aneligible preprint server on or after January 1, 2023.In preparation for the launch of this second phase, we have updated PMC and PubMed site features to help users of these databases incorporate the increased volume of preprints into their discovery workflows. S...
Source: PubMed Central News - January 10, 2023 Category: Databases & Libraries Source Type: news

Second Phase of the NIH Preprint Pilot Launched
Today, we are pleased to announce the launch of the second phase of the NIH Preprint Pilot with the addition of more than 700 new preprint records to PubMed Central (PMC) and PubMed. This second phase expands the scope of the Pilot to include preprints resulting from all NIH-funded research. Eligible preprints are those acknowledging direct support of an NIH award or authored by NIH staff and posted to bioRxiv, medRxiv, arXiv, or Research Square, on or after January 1, 2023. NLM will automatically include the full text of the preprint (as license terms allow) and associated citation information in PMC and PubMed, respectiv...
Source: PubMed Central News - January 30, 2023 Category: Databases & Libraries Source Type: news

Regulation of ovulatory genes in bovine granulosa cells: lessons from siRNA silencing of PTGS2
In this study, we compared the induction of these ovulatory genes in bovine granulosa cells (GCs) in vivo (after LH surge) and in vitro (forskolin (FRS) treatment). These genes were markedly stimulated in GCs isolated from cows 21 h after LH-surge. In isolated GCs, FRS induced a distinct temporal profile for each gene. Generally, there was a good agreement between the in vivo and in vitro inductions of these genes except for PTX3. Lack of PTX3 induction in isolated GCs culture suggests that other follicular compartments may mediate its induction by LH. Next, to study the role of PTGS2 and prostaglandins (PGs) in the cascad...
Source: Reproduction - November 28, 2014 Category: Reproduction Medicine Authors: Shrestha, K., Lukasik, K., Baufeld, A., Vanselow, J., Moallem, U., Meidan, R. Tags: Research Source Type: research

Implementing an Innovative Lipid Management Technique Using siRNA LDL-C Lowering Therapy: Lessons Learned in an NHS Primary Care Practice With Worked Case Examples
CONCLUSIONS: Enhanced lipid management as a secondary prevention measure is achievable in line with national guidance and objectives. The methodology and education/training processes used in combination with reconstructing the management process can help practice staff realize the program benefits, which in turn can lead to a shift in behavior where all staff embed manual case-finding of high-risk patients into everyday consultations and reviews; enabling rapid identification of eligible patients. Taking a multi-disciplinary, holistic approach to new initiatives reduces service burden, particularly for GPs. Leveraging reso...
Source: Primary Care - May 16, 2023 Category: Primary Care Authors: Carl Deaney Meredith Donaldson Agne Meskauskiene Source Type: research

Lipid-based nanocarriers for siRNA delivery: challenges, strategies and the lessons learned from the DODAX:MO liposomal system.
Abstract The possibility of using the RNA interference (RNAi) mechanisms in gene therapy was one of the scientific breakthroughs of the last century. Despite the extraordinary therapeutic potential of this approach, the need for an efficient gene carrier is hampering the translation of the RNAi technology to the clinical setting. Although a diversity of nanocarriers have been described, liposomes continue to be one of the most attractive siRNA vehicles due to their relatively low toxicity, facilitated siRNA complexation, high transfection efficiency and enhanced pharmacokinetic properties. This review focuses on R...
Source: Current Drug Targets - July 3, 2018 Category: Drugs & Pharmacology Authors: Oliveira ACN, Fernandes J, Goncalves A, Gomes AC, Oliveira R Tags: Curr Drug Targets Source Type: research

On RSS Readers, Divorce and Marriage
In just a few days, Google Reader will be history.  I've used it to create over 18,000 Tweets, so yes, I will miss Google Reader.  The end has pushed me into a divorce (or maybe it's just a separation?!) — from Google.  I describe my Google divorce as kind of like when a married couple with children decide to separate … they still have to see their exes for the sake of the kids (and I still have my blogs with Google's Blogger, for now anyway), and it may be a cordial, but not quite blissful separation, but is still necessary.A number of my fellow diabetes blogging peers have already migrated from Google'...
Source: Scott's Web Log - June 28, 2013 Category: Diabetes Authors: Scott S Source Type: blogs

Evolution of a Search: The Use of Dynamic Twitter Searches During Superstorm Sandy
Conclusion The most important lesson learned from Superstorm Sandy was the need for a dynamic and flexible monitoring process and strategy to understand and respond quickly to health needs in the areas impacted by Superstorm Sandy. Search strategies should change as frequently as the unfolding event. The inability to adapt to a changing situation ensures stale and stagnant terminology and search results. Twitter lists and Boolean searches should be used together to maximize situational awareness. The most important information comes from the impacted population, whether news, local government or local citizens. These are t...
Source: PLOS Currents Disasters - September 26, 2014 Category: Global & Universal Authors: Sara Harris Smith Source Type: research

Lessons from a systematic literature search on diagnostic DNA methylation biomarkers for colorectal cancer: how to increase research value and decrease research waste
DiscussionThis systematic literature search revealed that major requirements to develop clinically relevant diagnostic CRC DNA methylation markers are often lacking. To avoid the resulting research waste, clinical needs, intended biomarker use and independent validation should be better considered prior to study design. In addition, improved reporting quality would facilitate meta-analysis, thereby increasing level of evidence and enabling clinical translation.PMID:35584320 | DOI:10.14309/ctg.0000000000000499
Source: Clinical Colorectal Cancer - May 18, 2022 Category: Cancer & Oncology Authors: Zheng Feng Cary J G Oberije Alouisa J P van de Wetering Alexander Koch Kim A D Wouters Nathalie Vaes Ad A M Masclee Beatriz Carvalho Gerrit A Meijer Maurice P Zeegers James G Herman Veerle Melotte Manon van Engeland Kim M Smits Source Type: research

Application of Behavioral Theories to Disaster and Emergency Health Preparedness: A Systematic Review
CONCLUSIONS Based on the articles archived and selected, behavioral theories and models are applied to disasters and emergencies preparedness more commonly in developed countries (USA and Europe). In Asia, where the annual number of disasters events and victims exceed those in other continents, only 3 studies applying behavioral theories and models to disasters and emergencies were identifies. This identified a need for additional research to target the use of behavioral change theories in the Asian countries that bear the brunt of disasters and their consequences. This does not, however, mean that these theories have not ...
Source: PLOS Currents Disasters - July 1, 2015 Category: Global & Universal Authors: Luche Tadesse Ejeta Source Type: research