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Therapy: Statin Therapy
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Total 1112 results found since Jan 2013.
Myostatin serum levels in children with type 1 diabetes mellitus
CONCLUSION: Children with T1DM have significantly higher serum levels of myostatin compared to healthy children of the same age and BMI SD. The elevated myostatin in T1DM could reflect impaired muscle function and/or glucose metabolism, or could represent a homeostatic mechanism.PMID:34486100 | DOI:10.1007/s42000-021-00317-y
Source: Hormones - September 6, 2021 Category: Endocrinology Authors: Alexandra Efthymiadou Ioannis-Anargyros Vasilakis Aristeidis Giannakopoulos Dionisios Chrysis Source Type: research
mTORC2 is an important target for simvastatin-associated toxicity in C2C12 cells and mouse skeletal muscle - Roles of Rap1 geranylgeranylation and mitochondrial dysfunction
In conclusion, mTORC2 inhibition is an important mechanism of simvastatin-induced myotoxicity. Simvastatin inhibits mTORC2 by impairing geranylgeranylation of Rap1 and by inducing mitochondrial dysfunction.PMID:34461118 | DOI:10.1016/j.bcp.2021.114750
Source: Biochemical Pharmacology - August 30, 2021 Category: Drugs & Pharmacology Authors: Gerda M Sanvee Leonie Hitzfeld Jamal Bouitbir Stephan Kr ähenbühl Source Type: research
Addition of statins to the standard treatment in patients with cirrhosis: Safety and efficacy
The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients.PMID:34366626 | PMC:PMC8326251 | DOI:10.3748/wjg.v27.i28.4639
Source: World Journal of Gastroenterology : WJG - August 9, 2021 Category: Gastroenterology Authors: Alberto E Mu ñoz Florencia D Pollarsky M ónica Marino Mariano Cartier Horacio V ázquez Pablo Salgado Gustavo Romero Source Type: research
