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Anti-HMGCR antibodies and asymptomatic hyperCKemia. A case report
Acta Myol. 2021 Jun 30;40(2):105-108. doi: 10.36185/2532-1900-050. eCollection 2021 Jun.ABSTRACTAnti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) related myositis is a form of immune-mediated necrotizing myopathy (IMNM). Anti-HMGCR autoantibodies target HMGCR, a glycoprotein linked to the endoplasmic reticulum implied in the cholesterol synthesis pathway, and exert a pathogenic effect on skeletal muscle cells. More than 60% of patients affected by HMGCR-related myositis shares statin-exposure in their medical history. Patients commonly experience CK levels elevation, myalgia, muscle weakness and soreness at vari...
Source: Acta Myologica - August 6, 2021 Category: Neurology Authors: Francesca Torri Greta Ali Lucia Chico Gabriele Siciliano Giulia Ricci Source Type: research
