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Therapy: Statin Therapy

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Total 1112 results found since Jan 2013.

When Statins Get Physical: A Curious Cause of Statin Myopathy
We present the case of a 61-year-old male with hyperlipidemia and lumbar radiculopathy admitted to our hospital with rhabdomyolysis attributed to the recent initiation of statin therapy. Despite aggressive fluid resuscitation and an initial declination in his creatine phosphokinase (CPK) levels, he had persistent myalgias with progressive weakness. Rheumatologic and neurologic evaluation for other causes of myopathy were negative. Muscle biopsy obtained showed signs of necrosis and muscle regeneration. Given his recent statin use, persistent CPK elevation, proximal muscle weakness, and muscle biopsy findings, he was diagno...
Source: Southern Medical Journal - April 2, 2022 Category: General Medicine Authors: Puja P Patel Christopher D Jackson Source Type: research

Increased Risk of Statin ‐Associated Autoimmune Myopathy Among American Indians
Source: Arthritis and Rheumatology - March 25, 2022 Category: Rheumatology Authors: Jennie Wei, Elizabeth Ketner, Andrew L. Mammen Tags: Letters Source Type: research

Molecular targets of statins and their potential side effects: Not all the glitter is gold
Eur J Pharmacol. 2022 Mar 20:174906. doi: 10.1016/j.ejphar.2022.174906. Online ahead of print.ABSTRACTStatins are a class of drugs widely used worldwide to manage hypercholesterolemia and the prevention of secondary heart attacks. Currently, available statins vary in terms of their pharmacokinetic and pharmacodynamic profiles. Although the primary target of statins is the inhibition of HMG-CoA reductase (HMGR), the rate-limiting enzyme in cholesterol biosynthesis, statins exhibit many pleiotropic effects downstream of the mevalonate pathway. These pleiotropic effects include the ability to reduce myocardial fibrosis, patho...
Source: European Journal of Pharmacology - March 24, 2022 Category: Drugs & Pharmacology Authors: Kush K Patel Viren S Sehgal Khosrow Kashfi Source Type: research