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Procedure: Gastroschisis Repair
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Total 132 results found since Jan 2013.
Application of Supercharge End-to-Side (SETS) Obturator to Femoral Nerve Transfer in Electrical Injury-Induced Neuropathy to Improve Knee Extension
We report a devastating case of electrical injury-induced femoral neuropathy, where no apparent site of nerve disruption can be identified, thus inhibiting the traditional choices of nerve reconstruction such as nerve repair, grafting, or transfer. Concomitant spinal cord injury resulted in spastic myopathy of the antagonist muscles that further restricted knee extension. Our strategy was to perform (1) supercharge end-to-side technique (SETS) to augment the function of target muscles and (2) fractional tendon lengthening to release the spastic muscles. Dramatic postoperative improvement in passive and active range of moti...
Source: Archives of Plastic Surgery - December 16, 2022 Category: Cosmetic Surgery Authors: Katie Pei-Hsuan Wu Li-Ching Lin Johnny Chuieng-Yi Lu Source Type: research
A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle
We report the existence of a maturation checkpoint during muscle regeneration that pauses myofibers at a neonatal stage. This checkpoint is regulated by the mitochondrial protein mitofusin 2 (Mfn2), the expression of which is activated in response to muscle injury. Mfn2 is required for growth and maturation of regenerating myofibers; in the absence of Mfn2, new myofibers arrested at a neonatal stage, characterized by centrally nucleated myofibers and loss of H3K27me3 repressive marks at the neonatal myosin heavy chain gene. A similar arrest at the neonatal stage was observed in infantile cases of human centronuclear myopat...
Source: Journal of Clinical Investigation - December 1, 2022 Category: Biomedical Science Authors: Xun Wang, Yuemeng Jia, Jiawei Zhao, Nicholas P. Lesner, Cameron J. Menezes, Spencer D. Shelton, Siva Sai Krishna Venigalla, Jian Xu, Chunyu Cai, Prashant Mishra Source Type: research
The accumulation of muscle RING finger-1 in regenerating myofibers: Implications for muscle repair in immune-mediated necrotizing myopathy
ConclusionsMuRF-1 accumulated in regenerating myofibers, which may contribute to muscle injury repair in IMNM and DM. MuRF-1 staining may help clinicians differentiate IMNM and dysferlinopathy.
Source: Frontiers in Neurology - November 24, 2022 Category: Neurology Source Type: research
Restoration of Dystrophin Expression in Mdx-Derived Muscle Progenitor Cells Using CRISPR/Cas9 System and Homology-Directed Repair Technology
Methods Mol Biol. 2023;2587:455-464. doi: 10.1007/978-1-0716-2772-3_23.ABSTRACTDuchenne muscular dystrophy (DMD) is a progressive myopathy caused by mutations in genes encoding dystrophin proteins that ultimately lead to depletion of myogenic progenitor cells (MPCs). Several approaches have been used to correctly express the dystrophin gene in induced pluripotent stem cells (iPSCs), including deletion of mutated exon 23 (ΔEx23) by clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated gene 9 (Cas9)-mediated gene editing technology. However, this approach is labor-intensive due to individual co...
Source: Mol Biol Cell - November 18, 2022 Category: Molecular Biology Authors: Yue Jin Yan Shen Il-Man Kim Neal L Weintraub Mark Hamrick Yaoliang Tang Source Type: research
GSE207593 Effect of depletion of the gne gene in Zebrafish
Contributors : Hagay Livne ; Alon Daya ; Shmuel Ruppo ; Stella Mitrani-RosenbaumSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioGNE Myopathy is a rare, recessively inherited neuromuscular worldwide disorder, caused by a spectrum of bi-allelic mutations in the human GNE gene. GNE encodes a bi-functional enzyme responsible for the rate-limiting step of sialic acid biosynthesis pathway. However, the process in which GNE mutations lead to the development of a muscle pathology is not clear yet. Cellular and mouse models for GNE Myopathy established to date have not been informative. Further...
Source: GEO: Gene Expression Omnibus - October 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research
GSE202046 Effect of depletion of the Gne gene in Sol8 murine muscle cells
Contributors : Nili Ilouz ; Miriam Guttman ; Shmuel Ruppo ; Stella Mitrani-RosenbaumSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGNE myopathy is an adult onset neuromuscular disorder characterized by slowly progressive distal and proximal muscle weakness, caused by missense recessive mutations in the GNE gene. Although the encoded bifunctional enzyme is well known as the limiting factor in the biosynthesis of sialic acid, no clear mechanisms have been recognized to account for the muscle atrophic pathology, and novel functions for GNE have been hypothesized. No reliable animal mode...
Source: GEO: Gene Expression Omnibus - October 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
