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Total 42 results found since Jan 2013.

Large vessel vasculitis: a rare cause of isolated lower limb myopathy
Conclusions A thorough work up led to the diagnosis of polyarteritis nodosa as the cause of this patient’s isolated lower limb myopathy. No literature was found on this rare presentation of vasculitis.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 8, 2017 Category: Neurosurgery Authors: El-Wahsh, S., Weerasinghe, D., McDougall, A. Tags: Abstracts Source Type: research

Effects of different aerobic exercise frequencies on  streptozotocin‐nicotinamide‐induced type 2 diabetic rats: continuous versus short bouts and weekend warrior exercises
ConclusionsThe results of our study emphasized the impact of training on inflammation, increased oxidative stress, myopathy and mitochondrial damage in the rat model of streptozotocin‐nicotinamide‐induced T2DM, and demonstrated that there is no major difference between exercise modalities provided that the total duration of exercise remains the same.
Source: Journal of Diabetes - April 20, 2017 Category: Endocrinology Authors: Nuray Alaca, Serap Uslu, Guldal Gulec Suyen, Umit Ince, Mustafa Serteser, H ızır Kurtel Tags: Original Article Source Type: research

IgG4-Related Neuromyopathy Associated With Recurrent Pleural Effusion
Conclusions: We describe the first case, to our knowledge, of IgG4-related neuromyopathy associated with recurrent pleural effusion. Our case expands the clinical spectrum of IgG4-RD. Neurologists should be aware of this treatable disorder and in the appropriate clinical context consider it in the differential diagnosis of neuromyopathy.
Source: Journal of Clinical Neuromuscular Disease - May 22, 2015 Category: Neurology Tags: Original Article Source Type: research

Acute Cerebral Infarction as the Presenting Feature of anti-PL-7 Anti-Synthetase Syndrome (P5.126)
CONCLUSIONS: Anti-PL7 is one of eight known aminoacyl-tRNA synthetase (ARS) antibodies. Emerging evidence would suggest that each ARS antibody has a distinct phenotype. There is one report of acute infarction with cerebral vasculitis and anti-Jo1 ARS autoantibody. This is the first report of stroke in association with anti-PL7 anti-synthetase syndrome. Increased recognition of this disorder will allow for better delineation of the phenotype. Study Supported by:Disclosure: Dr. McNicholas has nothing to disclose. Dr. Henry has nothing to disclose. Dr. Ryan has received personal compensation for activities with Novartis, Merc...
Source: Neurology - April 8, 2015 Category: Neurology Authors: McNicholas, N., Henry, M., Ryan, A. Tags: Cerebrovascular Disease and Interventional Neurology: Biomarkers and Emerging Science Source Type: research

The Neuromuscular Features of Light Chain Deposition Disease (P5.056)
CONCLUSIONS: Clinicians need to be aware of LCDD myopathy, especially when amyloidosis is suspected and tissue testing is CR-negative. The generalized fibrillations were nearly gone just one week later, suggesting reversible sarcolemmal disruption possibly related to enhanced light chain renal excretion following aggressive hydration. Study Supported by:Disclosure: Dr. Zhang has nothing to disclose. Dr. Ferrante has nothing to disclose. Dr. Ly has nothing to disclose. Dr. Bertorini has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Zhang, L., Ferrante, M., Ly, H., Bertorini, T. Tags: Biomarkers of Neuromuscular Disease Source Type: research

INDACO project: COPD and link between comorbidities, lung function and inhalation therapy
Conclusions: Our study showed a high prevalence of comorbidities in COPD, with some differences related to gender. Number of comorbidities and airflow obstruction represent the determinant of inhalation therapy prescription. Dyspnoea and acute exacerbation of COPD, unlikely suggested by guidelines, are not significant drivers of therapy in the real life setting of our study.
Source: Epidemiologic Perspectives and Innovations - January 27, 2015 Category: Epidemiology Authors: Giorgio FumagalliFabrizio FabianiSilvia ForteMassimiliano NapolitanoGiovanni BalzanoMatteo BoniniGiuseppe De SimoneSalvatore FuschilloAntonella PentassugliaFranco PasquaPietro AlimontiStefano CarloneClaudio M Sanguinetti Source Type: research

Moving to connective tissue disease
We present an approach to the neurological presentations of CTD and reveal possible manifestations and important treatment considerations.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Singh, A., Sivagnanasundaram, J., Doshi, A., Kock, N. Tags: Abstracts Source Type: research

In vivo characterization of the role of tissue‐specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy
Translation elongation factor 1A2 (eEF1A2), uniquely among translation factors, is expressed specifically in neurons and muscle. eEF1A2‐null mutant wasted mice develop an aggressive, early‐onset form of neurodegeneration, but it is unknown whether the wasting results from denervation of the muscles, or whether the mice have a primary myopathy resulting from loss of translation activity in muscle. We set out to establish the relative contributions of loss of eEF1A2 in the different tissues to this postnatal lethal phenotype. We used tissue‐specific transgenesis to show that correction of eEF1A2 levels in muscle fails...
Source: FEBS Journal - October 23, 2013 Category: Research Authors: Jennifer Doig, Lowri A. Griffiths, David Peberdy, Permphan Dharmasaroja, Maria Vera, Faith J. C. Davies, Helen J. Newbery, David Brownstein, Catherine M. Abbott Tags: Original Article Source Type: research

In Vivo Characterisation of the Role of Tissue‐specific Translation Elongation Factor eEF1A2 in Protein Synthesis Reveals Insights into Muscle Atrophy
This article is protected by copyright. All rights reserved.
Source: FEBS Journal - October 2, 2013 Category: Research Authors: Jennifer Doig, Lowri A. Griffiths, David Peberdy, Permphan Dharmasaroja, Maria Vera, Faith J.C. Davies, Helen J. Newbery, David Brownstein, Catherine M. Abbott Tags: Original Article Source Type: research

Chronic intestinal pseudo-obstruction.
Abstract Chronic intestinal pseudo-obstruction (CIP) is a rare and serious disorder of the gastrointestinal (GI) tract characterized as a motility disorder with the primary defect of impaired peristalsis; symptoms are consistent with a bowel obstruction, although mechanical obstruction cannot be identified. CIP is classified as a neuropathy, myopathy, or mesenchymopathy; it is a neuropathic process in the majority of patients. The natural history of CIP is generally that of a progressive disorder, although occasional patients with secondary CIP note significant symptomatic improvement when the underlying disorder ...
Source: Nutrition in Clinical Practice - May 25, 2013 Category: Nutrition Authors: Gabbard SL, Lacy BE Tags: Nutr Clin Pract Source Type: research

Mitochondrial encoded NADH dehydrogenase 5 (MT-ND5) gene point mutation presents as late onset cardiomyopathy
A 47-year old man, recent immigrant from Haiti, presented with 3days of dyspnea and leg edema. The patient was in good health until 7years prior to presentation, when he developed progressive diplopia, ptosis, dysphagia, garbled speech, weight loss and weakness in his extremities. No cognitive changes were noted. Despite muscle weakness, he could perform all of his normal daily activities. He also denied dyspnea, orthopnea, chest pain, syncope or prior heart disease. Family history was non-contributory. Neurologic examination revealed bilateral ptosis, bilateral ophthalmoplegia and diffuse muscular atrophy. Neuro-ophthalm...
Source: International Journal of Cardiology - April 29, 2013 Category: Cardiology Authors: Nir Ayalon, Leigh Anne Flore, Thomas G. Christensen, Flora Sam Tags: Online Letters to the Editor Source Type: research