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Specialty: Gastroenterology
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Total 4295 results found since Jan 2013.
SARS-CoV-2 induced liver injury: Incidence, risk factors, impact on COVID-19 severity and prognosis in different population groups
World J Gastroenterol. 2023 Apr 28;29(16):2397-2432. doi: 10.3748/wjg.v29.i16.2397.ABSTRACTLiver is unlikely the key organ driving mortality in coronavirus disease 2019 (COVID-19) however, liver function tests (LFTs) abnormalities are widely observed mostly in moderate and severe cases. According to this review, the overall prevalence of abnormal LFTs in COVID-19 patients ranges from 2.5% to 96.8% worldwide. The geographical variability in the prevalence of underlying diseases is the determinant for the observed discrepancies between East and West. Multifactorial mechanisms are implicated in COVID-19-induced liver injury. ...
Source: World Journal of Gastroenterology - May 14, 2023 Category: Gastroenterology Authors: George D Liatsos Source Type: research
Incorporating the Molecular Mimicry of Environmental Antigens into the Causality of Autoimmune Hepatitis
In conclusion, molecular mimicry may be a missing causality of autoimmune hepatitis. Molecular mimics of key immune dominant epitopes of disease-specific antigens must be sought in diverse environmental antigens. The ubiquity of molecular mimicry compels rigorous assessments of peptide mimics for immunogenicity and pathogenicity in experimental models. Molecular mimicry may complement epigenetic modifications as causative mechanisms of autoimmune hepatitis.
Source: Digestive Diseases and Sciences - May 9, 2023 Category: Gastroenterology Source Type: research
Occam's razor or Hickam's dictum-COVID-19 is not a textbook aetiology of acute pancreatitis: A modified Naranjo Score appraisal
CONCLUSION: Current evidence is weak to establish a strong link between COVID-19 and AP. Investigations should be performed to rule out other causes of AP before establishing COVID-19 as an aetiology.PMID:37155526 | PMC:PMC10122789 | DOI:10.3748/wjg.v29.i13.2050
Source: World Journal of Gastroenterology : WJG - May 8, 2023 Category: Gastroenterology Authors: Thomas Zheng Jie Teng Branden Qi Yu Chua Puay Khim Lim Kai Siang Chan Vishal G Shelat Source Type: research
Interferon-lambda: New role in intestinal symptoms of COVID-19
World J Gastroenterol. 2023 Apr 7;29(13):1942-1954. doi: 10.3748/wjg.v29.i13.1942.ABSTRACTThe tremendous public health and economic impact of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a huge challenge globally. There is increasing evidence that SARS-CoV-2 induces intestinal infections. Type III interferon (IFN-λ) has an antiviral role in intestinal infection, with focused, long-lasting, and non-inflammatory characteristics. This review presents a summary of the structure of SARS-CoV-2, including its invasion and immune escape mechanisms. Emphasi...
Source: World Journal of Gastroenterology : WJG - May 8, 2023 Category: Gastroenterology Authors: Yi-Yang Pan Liu-Can Wang Feng Yang Min Yu Source Type: research
Occam's razor or Hickam's dictum-COVID-19 is not a textbook aetiology of acute pancreatitis: A modified Naranjo Score appraisal
CONCLUSION: Current evidence is weak to establish a strong link between COVID-19 and AP. Investigations should be performed to rule out other causes of AP before establishing COVID-19 as an aetiology.PMID:37155526 | PMC:PMC10122789 | DOI:10.3748/wjg.v29.i13.2050
Source: World Journal of Gastroenterology - May 8, 2023 Category: Gastroenterology Authors: Thomas Zheng Jie Teng Branden Qi Yu Chua Puay Khim Lim Kai Siang Chan Vishal G Shelat Source Type: research
Interferon-lambda: New role in intestinal symptoms of COVID-19
World J Gastroenterol. 2023 Apr 7;29(13):1942-1954. doi: 10.3748/wjg.v29.i13.1942.ABSTRACTThe tremendous public health and economic impact of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a huge challenge globally. There is increasing evidence that SARS-CoV-2 induces intestinal infections. Type III interferon (IFN-λ) has an antiviral role in intestinal infection, with focused, long-lasting, and non-inflammatory characteristics. This review presents a summary of the structure of SARS-CoV-2, including its invasion and immune escape mechanisms. Emphasi...
Source: World Journal of Gastroenterology - May 8, 2023 Category: Gastroenterology Authors: Yi-Yang Pan Liu-Can Wang Feng Yang Min Yu Source Type: research
