Filtered By:
Specialty: Drugs & Pharmacology
This page shows you your search results in order of date. This is page number 4.
Order by Relevance | Date
Total 121044 results found since Jan 2013.
Shrinking the Battlefield in Cancer Therapy: Nanotechnology Against Cancer Stem Cells
In conclusion, nanotechnology presents a novel, powerful tool in the fight against cancer, particularly in targeting the elusive and treatment-resistant CSCs. This comprehensive review delves into the intricacies of nanotherapy, explicitly targeting cancer stem cells, their markers, and associated signaling pathways.PMID:37729956 | DOI:10.1016/j.ejps.2023.106586
Source: European Journal of Pharmaceutical Sciences - September 20, 2023 Category: Drugs & Pharmacology Authors: Queenie Fernandes Lubna Therachiyil Abdul Q Khan Takwa Bedhiafi Hesham M Korashy Ajaz A Bhat Shahab Uddin Source Type: research
Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation
This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVE...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Francisco Villalba-L ópez David Garc ía-Bernal Sandra V Mateo Daniel Vidal-Correoso Marta Jover-Aguilar Felipe Alconchel Laura Mart ínez-Alarcón V íctor López-López Antonio R íos-Zambudio Pedro Cascales Jos é A Pons Pablo Ram írez Pablo Pelegr Source Type: research
Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions
Biomed Pharmacother. 2023 Sep 18;167:115538. doi: 10.1016/j.biopha.2023.115538. Online ahead of print.ABSTRACTTripartite motif (TRIM) family is assigned to RING-finger-containing ligases harboring the largest number of proteins in E3 ubiquitin ligating enzymes. E3 ubiquitin ligases target the specific substrate for proteasomal degradation via the ubiquitin-proteasome system (UPS), which seems to be a more effective and direct strategy for tumor therapy. Recent advances have demonstrated that TRIM genes associate with the occurrence and progression of hepatocellular carcinoma (HCC). TRIMs trigger or inhibit multiple biologi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Jie Zhang Yuting Zhou Jiao Feng Xuanfu Xu Jianye Wu Chuanyong Guo Source Type: research
Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease
Biomed Pharmacother. 2023 Sep 18;167:115469. doi: 10.1016/j.biopha.2023.115469. Online ahead of print.ABSTRACTExtracellular matrix (ECM) is an active player in cardiovascular calcification (CVC), a major public health issue with an unmet need for effective therapies. Lysyl oxidase (LOX) conditions ECM biomechanical properties; thus, we hypothesized that LOX might impact on mineral deposition in calcific aortic valve disease (CAVD) and atherosclerosis. LOX was upregulated in calcified valves from two cohorts of CAVD patients. Strong LOX immunostaining was detected surrounding calcified foci in calcified human valves and ath...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Carme Ballester-Servera Judith Alonso Laia Ca ñes Paula V ázquez-Sufuentes L ídia Puertas-Umbert Amaya Fern ández-Celis Manel Taur ón Antonio Rodr íguez-Sinovas Natalia L ópez-Andrés Cristina Rodr íguez Jos é Martínez-González Source Type: research
Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects
Biomed Pharmacother. 2023 Sep 18;167:115519. doi: 10.1016/j.biopha.2023.115519. Online ahead of print.ABSTRACTProtein acetylation modifications play a central and pivotal role in a myriad of biological processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and beyond, by effectively reshaping protein structure and function. The metabolic state of cells is intricately connected to epigenetic modifications, which in turn influence chromatin status and gene expression patterns. Notably, pathological alterations in protein acetylation modifications are frequently observed in diseases such as metabo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Nan Jiang Wenyong Li Shuanglin Jiang Ming Xie Ran Liu Source Type: research
Chronic exposure to l-BMAA cyanotoxin induces cytoplasmic TDP-43 accumulation and glial activation, reproducing an amyotrophic lateral sclerosis-like phenotype in mice
CONCLUSIONS: Overall, our results characterize a new versatile neurotoxic animal model of ALS that may be useful for the identification of new druggable targets to develop innovative therapeutic strategies for this disease.PMID:37729728 | DOI:10.1016/j.biopha.2023.115503
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Serenella Anzilotti Valeria Valente Paola Brancaccio Cristina Franco Antonella Casamassa Giovanna Lombardi Alessandra Palazzi Andrea Conte Simona Paladino Lorella Maria Teresa Canzoniero Lucio Annunziato Giovanna Maria Pierantoni Giuseppe Pignataro Source Type: research
Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage polarization and chondrocyte apoptosis
In this study, we found that TUC339 was lower in the research group than in the control group and it was negatively correlated with IL-6, IL-8 and TNF-α. Prognosis TUC339 was lower in patients with recurrent OA than in those without recurrence, and ROC analysis manifested that TUC339 had a better predictive value for recurrence of OA. Phenotypic identification revealed elevated expression of CD29 and CD44 in BMSCs and TSG101, CD63 and CD81 in BMSCs-exosome (BMSCs-exo), with a stem cell versus exosome phenotype. Finally, animal experiments improved significantly in joint injury in the BMSCs-exo and TUC339-overexpression ve...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xun Shen Jian Qin Zijian Wei Feng Liu Source Type: research
Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors
Biomed Pharmacother. 2023 Sep 18;167:115534. doi: 10.1016/j.biopha.2023.115534. Online ahead of print.ABSTRACTThe analgesic effects of sigma-1 antagonists are undisputed, but the effects of sigma-1 agonists on pain are not well studied. Here, we used a mouse model to show that the administration of the sigma-1 agonists dextromethorphan (a widely used antitussive drug), PRE-084 (a standard sigma-1 ligand), and pridopidine (a selective drug being investigated in clinical trials for the treatment of neurodegenerative diseases) enhances PGE2-induced mechanical hyperalgesia. Superficial plantar incision induced transient weight...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: M Carmen Ruiz-Cantero Miguel Á Huerta Miguel Á Tejada Miriam Santos-Caballero Eduardo Fern ández-Segura Francisco J Ca ñizares Jos é M Entrena Jos é M Baeyens Enrique J Cobos Source Type: research
Impact of ferroptosis on preeclampsia: A review
Biomed Pharmacother. 2023 Sep 18;167:115466. doi: 10.1016/j.biopha.2023.115466. Online ahead of print.ABSTRACTPreeclampsia (PE) is usually associated with the accumulation of reactive oxygen species (ROS) resulting from heightened oxidative stress (OS). Ferroptosis is a unique type of lipid peroxidation-induced iron-dependent cell death distinct from traditional apoptosis, necroptosis, and pyroptosis and most likely contributes considerable to PE pathogenesis. At approximately 10-12 weeks of gestation, trophoblasts create an environment rich in oxygen and iron. In patients with PE, ferroptosis-related genes such as HIF1 an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Yuping Shan Chengcheng Guan Jingli Wang Weihong Qi Aiping Chen Shiguo Liu Source Type: research
Nucleic Acid Nanomaterials: Biostability and Applications
Curr Drug Metab. 2023;24(5):314. doi: 10.2174/138920022405230824141125.NO ABSTRACTPMID:37728080 | DOI:10.2174/138920022405230824141125
Source: Current Drug Metabolism - September 20, 2023 Category: Drugs & Pharmacology Authors: Shaojingya Gao YunFeng Lin Source Type: research
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy
Can J Physiol Pharmacol. 2023 Sep 20. doi: 10.1139/cjpp-2023-0083. Online ahead of print.ABSTRACTThe tumour is fully functional in the zone of action of immune mediators. Moreover, the tumour needs immune system mediators to survive. "Adaptation" refers to a tumour's ability to withstand the effect of harmful elements. This gives birth to a new form of antitumour therapy: blocking tumour adaptability pathways. In this review, we will look at (i) tumour adaptation mechanisms as a result of pro-tumour immunoediting, (ii) how understanding tumour-adaptive mechanisms has led to ideas for developing cancer immunotherapies, and ...
Source: Canadian Journal of Physiology and Pharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: I Yu Malyshev O P Budanova L V Kuznetsova Source Type: research
Exosome-hijacking drug delivery system with branched arginine linker effectively deliver antisense oligonucleotides into lung adenocarcinoma cells
In this study, we modified ExomiR-Tracker by incorporating branched nona-D-arginines (9 + 9 mer) molecules (referred to as Branch ExomiR-Tracker) and evaluated its efficacy in lung adenocarcinoma cells (A549 cells). The improved complex formation ability and enhanced cellular uptake of anti-miR, demonstrated by our findings, highlight the advantages of incorporating branched oligoarginine peptides into the ExomiR-Tracker platform. These results represent significant progress in revealing the effectiveness of Branch ExomiR-Tracker against adhesive cancer cells, which has not been shown to be effective with the conventional ...
Source: Chemical and Pharmaceutical Bulletin - September 20, 2023 Category: Drugs & Pharmacology Authors: Shota Oyama Mao Tomita Moeka Hata Yu Mikame Tsuyoshi Yamamoto Eishi Ashihara Asako Yamayoshi Source Type: research
Clinical pharmacology of β-3 adrenergic receptor agonists for cardiovascular diseases
Expert Rev Clin Pharmacol. 2023 Sep 20:1-12. doi: 10.1080/17512433.2023.2193681. Online ahead of print.ABSTRACTINTRODUCTION: Few agonists of the third isotype of beta-adrenergic receptors, the β3-adrenoreceptor, are currently used clinically, and new agonists are under development for the treatment of overactive bladder disease. As the receptor is expressed in human cardiac and vascular tissues, it is important to understand their beneficial (or adverse) effect(s) on these targets.AREAS COVERED: We discuss the most recent results of clinical trials testing the benefit and safety of β3-adrenoreceptor activation on cardiov...
Source: Pharmacological Reviews - September 20, 2023 Category: Drugs & Pharmacology Authors: Jean-Luc Balligand Lauriane Y M Michel Source Type: research
Personalized neoantigen cancer vaccines: An analysis of the clinical and commercial potential of ongoing development programs
Drug Discov Today. 2023 Sep 18:103773. doi: 10.1016/j.drudis.2023.103773. Online ahead of print.ABSTRACTNeoantigen cancer vaccines harbor promise as next-generation immuno-oncology therapies, whereby cancer vaccines are tailored to the patient's tumor antigen and represent the future of personalized cancer therapy. While several biotech companies have ongoing development programs, little has been published about the true commercial potential of these innovative therapies and the challenges these products will face upon regulatory approval. In this paper, we provide an overview of neoantigen cancer vaccine development progr...
Source: Drug Discovery Today - September 20, 2023 Category: Drugs & Pharmacology Authors: Maurice Perrinjaquet C Richard Schlegel Source Type: research
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway
In this study, we found that SIRT1 is closely related to expression of GLP-1R in hippocampus of 3xTg mice. Therefore, we used semaglutide, a novel GLP-1R agonist currently undergoing two phase 3 clinical trials in AD patients, to observe the effect of SIRT1 after semaglutide treatment in 3XTg mice and HT22 cells, and to explore the mechanism of SIRT1 in the glucose metabolism disorders of AD. The mice were injected with semaglutide on alternate days for 30 days, followed by behavioral experiments including open field test, new object recognition test, and Y-maze. The content of glucose in the brain was also measured by usi...
Source: Neuropharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: Zhao-Jun Wang Xin-Ru Li Shi-Fan Chai Wei-Ran Li Shuo Li Meng Hou Jia-Lei Li Yu-Cai Ye Hong-Yan Cai Christian H ölscher Mei-Na Wu Source Type: research
