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Procedure: Kidney Transplant
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Total 40196 results found since Jan 2013.
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation
Cell Stem Cell. 2023 Sep 7;30(9):1235-1245.e6. doi: 10.1016/j.stem.2023.08.003.ABSTRACTHeterologous organ transplantation is an effective way of replacing organ function but is limited by severe organ shortage. Although generating human organs in other large mammals through embryo complementation would be a groundbreaking solution, it faces many challenges, especially the poor integration of human cells into the recipient tissues. To produce human cells with superior intra-niche competitiveness, we combined optimized pluripotent stem cell culture conditions with the inducible overexpression of two pro-survival genes (MYCN ...
Source: Cell Stem Cell - September 8, 2023 Category: Stem Cells Authors: Jiaowei Wang Wenguang Xie Nan Li Wenjuan Li Zhishuai Zhang Nana Fan Zhen Ouyang Yu Zhao Chengdan Lai Hao Li Mengqi Chen Longquan Quan Yunpan Li Yu Jiang Wenqi Jia Lixin Fu Md Abdul Mazid Yanling Zhu Patrick H Maxwell Guangjin Pan Miguel A Esteban Zhen Dai Source Type: research
Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe Akkermansia muciniphila and modulating glutamine metabolism
In this study, we demonstrated the dose-dependent attenuation of RIF by Ootheca mantidis (SPX), a commonly prescribed TCM for CKD, in a mouse model of unilateral ureteral obstruction (UUO). RNA-sequencing analysis suggested that SPX treatment prominently downregulated apoptosis and inflammation-associated pathways, thereby inhibiting the fibrogenic signaling in the kidney. We further found that transplantation of fecal microbiota from SPX-treated mice conferred protection against renal injury and fibrosis through suppressing apoptosis in UUO mice, indicating that SPX ameliorated RIF via remodeling the gut microbiota and re...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 7, 2023 Category: Drugs & Pharmacology Authors: Jue Wang Xiaozhen Guo Ziyuan Zou Minjun Yu Xueling Li Hualing Xu Yiping Chen Tingying Jiao Kanglong Wang Yuandi Ma Jie Jiang Xinyu Liang Jiawen Wang Cen Xie Yifei Zhong Source Type: research
Renal transplant waiting list mortality in COVID era: is it advisable to halt transplant activity?
CONCLUSION: The probability of death of a patient with ESRD with delayed follow-up visits and transplant retention is statistically higher than the probability of death from COVID-19.PMID:37677955 | DOI:10.24875/CIRU.21000718
Source: Cirugia y Cirujanos - September 7, 2023 Category: Surgery Authors: Jorge Mart ínez-Ulloa-Torres Paulo Guti érrez-Torres Pablo Castro-Ruiz Patricia B Bolado-Garc ía Mariano Hernandez-Dominguez Luis F Aguilar-Castillejos Mauro E Tun-Abraham Juan P Baas-Cruz Source Type: research
Targeting pharmacotherapies for inflammatory and cardiorenal endpoints in kidney disease
J Cardiovasc Pharmacol. 2023 Sep 5. doi: 10.1097/FJC.0000000000001482. Online ahead of print.ABSTRACTInflammation is an important contributor to excess cardiovascular risk and progressive renal injury in people with CKD. Dysregulation of the innate and adaptive immune system is accelerated by CKD and results in increased systemic inflammation, a heightened local vascular inflammatory response leading to accelerated atherosclerosis, and dysfunction of the cardiac and renal endothelium and microcirculation. Understanding and addressing the dysregulated immune system is a promising approach to modifying cardiorenal outcomes i...
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Daniel M Huck Leo F Buckley Anil Chandraker Ron Blankstein Brittany Weber Source Type: research
Dialysis after kidney transplant failure: how to deal with this daunting task?
J Nephrol. 2023 Sep 7. doi: 10.1007/s40620-023-01758-x. Online ahead of print.ABSTRACTThe best treatment for patients with end-stage kidney disease is kidney transplantation, which, if successful provides both a reduction in mortality and a better quality of life compared to dialysis. Although there has been significant improvement in short-term outcomes after kidney transplantation, long-term graft survival still remains insufficient. As a result, there has been an increase in the number of individuals who need dialysis again after kidney transplant failure, and increasingly contribute to kidney transplant waiting lists. ...
Source: Journal of Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Cem Tanriover Sidar Copur Carlo Basile Duygu Ucku Mehmet Kanbay Source Type: research
Elevated tacrolimus levels among COVID-19 kidney transplant recipients are associated with worse disease severity and clinical outcomes
CONCLUSION: Elevated tacrolimus levels occur in many renal transplant recipients with moderate to severe COVID-19 and are associated with worse clinical outcomes. Close drug monitoring is crucial to avoid toxicities and minimize over-immunosuppression complications.PMID:37675489 | DOI:10.5414/CN111137
Source: Clinical Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Angelito Yango Bipin Bista Bernard Fischbach Shana Machado Alexandra Clark Sanna Khoja Nicole Dion Giovana Saracino Jessica Taylor Hoylan Fernandez Sathishkumar Seeliyur Duraiswamy Giuliano Testa Source Type: research
Renal transplant waiting list mortality in COVID era: is it advisable to halt transplant activity?
CONCLUSION: The probability of death of a patient with ESRD with delayed follow-up visits and transplant retention is statistically higher than the probability of death from COVID-19.PMID:37677955 | DOI:10.24875/CIRU.21000718
Source: Cirugia y Cirujanos - September 7, 2023 Category: Surgery Authors: Jorge Mart ínez-Ulloa-Torres Paulo Guti érrez-Torres Pablo Castro-Ruiz Patricia B Bolado-Garc ía Mariano Hernandez-Dominguez Luis F Aguilar-Castillejos Mauro E Tun-Abraham Juan P Baas-Cruz Source Type: research
Dialysis after kidney transplant failure: how to deal with this daunting task?
J Nephrol. 2023 Sep 7. doi: 10.1007/s40620-023-01758-x. Online ahead of print.ABSTRACTThe best treatment for patients with end-stage kidney disease is kidney transplantation, which, if successful provides both a reduction in mortality and a better quality of life compared to dialysis. Although there has been significant improvement in short-term outcomes after kidney transplantation, long-term graft survival still remains insufficient. As a result, there has been an increase in the number of individuals who need dialysis again after kidney transplant failure, and increasingly contribute to kidney transplant waiting lists. ...
Source: Journal of Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Cem Tanriover Sidar Copur Carlo Basile Duygu Ucku Mehmet Kanbay Source Type: research
Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe Akkermansia muciniphila and modulating glutamine metabolism
In this study, we demonstrated the dose-dependent attenuation of RIF by Ootheca mantidis (SPX), a commonly prescribed TCM for CKD, in a mouse model of unilateral ureteral obstruction (UUO). RNA-sequencing analysis suggested that SPX treatment prominently downregulated apoptosis and inflammation-associated pathways, thereby inhibiting the fibrogenic signaling in the kidney. We further found that transplantation of fecal microbiota from SPX-treated mice conferred protection against renal injury and fibrosis through suppressing apoptosis in UUO mice, indicating that SPX ameliorated RIF via remodeling the gut microbiota and re...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 7, 2023 Category: Drugs & Pharmacology Authors: Jue Wang Xiaozhen Guo Ziyuan Zou Minjun Yu Xueling Li Hualing Xu Yiping Chen Tingying Jiao Kanglong Wang Yuandi Ma Jie Jiang Xinyu Liang Jiawen Wang Cen Xie Yifei Zhong Source Type: research
Elevated tacrolimus levels among COVID-19 kidney transplant recipients are associated with worse disease severity and clinical outcomes
CONCLUSION: Elevated tacrolimus levels occur in many renal transplant recipients with moderate to severe COVID-19 and are associated with worse clinical outcomes. Close drug monitoring is crucial to avoid toxicities and minimize over-immunosuppression complications.PMID:37675489 | DOI:10.5414/CN111137
Source: Clinical Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Angelito Yango Bipin Bista Bernard Fischbach Shana Machado Alexandra Clark Sanna Khoja Nicole Dion Giovana Saracino Jessica Taylor Hoylan Fernandez Sathishkumar Seeliyur Duraiswamy Giuliano Testa Source Type: research
Sodium First Approach, to Reset Our Mind for Improving Management of Sodium, Water, Volume and Pressure in Hemodialysis Patients, and to Reduce Cardiovascular Burden and Improve Outcomes
Front Nephrol. 2022 Jul 7;2:935388. doi: 10.3389/fneph.2022.935388. eCollection 2022.ABSTRACTNew physiologic findings related to sodium homeostasis and pathophysiologic associations require a new vision for sodium, fluid and blood pressure management in dialysis-dependent chronic kidney disease patients. The traditional dry weight probing approach that has prevailed for many years must be reviewed in light of these findings and enriched by availability of new tools for monitoring and handling sodium and water imbalances. A comprehensive and integrated approach is needed to improve further cardiac health in hemodialysis (HD...
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Bernard Canaud Jeroen Kooman Andreas Maierhofer Jochen Raimann Jens Titze Peter Kotanko Source Type: research
Elevated tacrolimus levels among COVID-19 kidney transplant recipients are associated with worse disease severity and clinical outcomes
CONCLUSION: Elevated tacrolimus levels occur in many renal transplant recipients with moderate to severe COVID-19 and are associated with worse clinical outcomes. Close drug monitoring is crucial to avoid toxicities and minimize over-immunosuppression complications.PMID:37675489 | DOI:10.5414/CN111137
Source: Clinical Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Angelito Yango Bipin Bista Bernard Fischbach Shana Machado Alexandra Clark Sanna Khoja Nicole Dion Giovana Saracino Jessica Taylor Hoylan Fernandez Sathishkumar Seeliyur Duraiswamy Giuliano Testa Source Type: research
Dialysis after kidney transplant failure: how to deal with this daunting task?
J Nephrol. 2023 Sep 7. doi: 10.1007/s40620-023-01758-x. Online ahead of print.ABSTRACTThe best treatment for patients with end-stage kidney disease is kidney transplantation, which, if successful provides both a reduction in mortality and a better quality of life compared to dialysis. Although there has been significant improvement in short-term outcomes after kidney transplantation, long-term graft survival still remains insufficient. As a result, there has been an increase in the number of individuals who need dialysis again after kidney transplant failure, and increasingly contribute to kidney transplant waiting lists. ...
Source: Journal of Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Cem Tanriover Sidar Copur Carlo Basile Duygu Ucku Mehmet Kanbay Source Type: research
