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Education: Lessons
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Total 21656 results found since Jan 2013.
Epithelial inflammasomes, gasdermins, and mucosal inflammation - Lessons from Salmonella and Shigella infected mice
Semin Immunol. 2023 Aug 8;70:101812. doi: 10.1016/j.smim.2023.101812. Online ahead of print.ABSTRACTBesides its crucial function in nutrient absorbance and as barrier against the microbiota, the gut epithelium is essential for sensing pathogenic insults and mounting of an appropriate early immune response. In mice, the activation of the canonical NAIP/NLRC4 inflammasome is critical for the defense against enterobacterial infections. Activation of the NAIP/NLRC4 inflammasome triggers the extrusion of infected intestinal epithelial cells (IEC) into the gut lumen, concomitant with inflammasome-mediated lytic cell death. The m...
Source: Seminars in Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Ersin G ül Stefan A Fattinger Mikael E Sellin Wolf-Dietrich Hardt Source Type: research
Five years of caplacizumab - Lessons learned and remaining controversies in immune-mediated thrombotic thrombocytopenic purpura
J Thromb Haemost. 2023 Aug 8:S1538-7836(23)00591-3. doi: 10.1016/j.jtha.2023.07.027. Online ahead of print.ABSTRACTImmune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare hematologic disease caused by autoantibodies against ADAMTS13 that trigger a microangiopathic hemolytic anemia. Therapeutic plasma exchange and glucocorticoids have been the mainstay of treatment for the past 30 years. In 2019, caplacizumab was approved as an addition to this regimen for the acute treatment of iTTP. Randomized controlled trials and real-world evidence have shown that caplacizumab reduces the time to platelet count normalizati...
Source: Thrombosis and Haemostasis - August 10, 2023 Category: Hematology Authors: Linus Alexander Volker Paul Thomas Brinkkoetter Spero R Cataland Camila Masias Source Type: research
When Development of the Alveolar Gas Exchange Unit Fails: Universal Single Cell Lessons from Rare Monogenic Disorders
Am J Respir Crit Care Med. 2023 Aug 9. doi: 10.1164/rccm.202307-1271ED. Online ahead of print.NO ABSTRACTPMID:37555730 | DOI:10.1164/rccm.202307-1271ED
Source: Respiratory Care - August 9, 2023 Category: Respiratory Medicine Authors: Jonas C Schupp Naftali Kaminski Source Type: research
Aspects of Program Engagement in an Online Physical Activity Intervention and Baseline Predictors of Engagement
CONCLUSION: Examining multiple aspects of engagement and a large number of potential predictors of engagement is likely needed to determine facilitators and barriers for high engagement in multi-faceted online intervention programs.PMID:37550892 | DOI:10.1177/08901171231194176
Source: American Journal of Health Promotion : AJHP - August 8, 2023 Category: International Medicine & Public Health Authors: Reagan Moffit Kathleen McTigue Molly B Conroy Andrea Kriska Gary Fischer Edmund Ricci David Dunstan Sarah Deperrior Neel Rao Lora E Burke Bonny Rockette-Wagner Source Type: research
Learning from history of natural disasters in the Sahel: a comprehensive analysis and lessons for future resilience
This study investigates the extent of damage caused by natural disasters from one of the most widely used databases-EM-DAT-with a sample size of 16 Sahelian countries over the period 1960-2020. These countries have been divided into three regions: Western Africa Sahel (WAS), Central Africa Sahel (CAS), and Eastern Africa Sahel (EAS). The analyses encompass four categories of natural hazards, namely, biological, climatological, hydrological, and meteorological. We used descriptive and test statistics to summarize the natural disaster records. Through this approach, we explore tendencies to identify the most frequently repor...
Source: Environmental Science and Pollution Research International - August 7, 2023 Category: Environmental Health Authors: Serigne Mback é Coly Malicki Zorom Babacar Leye Harouna Karambiri Aboudramane Guiro Source Type: research
The evolution of technical prerequisites and local boundary conditions for optimization of mitral valve interventions-Emphasis on skills development and institutional risk performance
Front Cardiovasc Med. 2023 Jul 21;10:1101337. doi: 10.3389/fcvm.2023.1101337. eCollection 2023.ABSTRACTThis viewpoint report describes how the evolution of transcatheter mitral valve intervention (TMVI) is influenced by lessons learned from three evolutionary tracks: (1) the development of treatment from mitral valve surgery (MVS) to transcutaneous procedures; (2) the evolution of biomedical engineering for research and development resulting in predictable and safe clinical use; (3) the adaptation to local conditions, impact of transcatheter aortic valve replacement (TAVR) experience and creation of infrastructure for skil...
Source: Molecular Medicine - August 7, 2023 Category: Molecular Biology Authors: Riccardo Cocchieri Bertus van de Wetering Jan Baan Antoine Driessen Robert Riezebos Sjoerd van Tuijl Bas de Mol Source Type: research
Tracking emergency response actions during COVID-19 leads to development of an innovative public health evaluation tool
Can J Public Health. 2023 Aug 7. doi: 10.17269/s41997-023-00811-3. Online ahead of print.ABSTRACTSETTING: Early in the pandemic, KFL&A Public Health needed a way to capture, organize, and display COVID-19-related events to be accountable for and evaluate our actions.INTERVENTION: We used accessible software (Microsoft Office 365 suite, Microsoft PowerBI) to develop a data collection and visualization system. The Canadian Institute for Health Information (CIHI) developed a timeline and categorization approach for provincial and national COVID-related interventions, which was used to develop a regional version for local ...
Source: Canadian Journal of Public Health - August 7, 2023 Category: International Medicine & Public Health Authors: Suzanne Biro Karen Scott Emma Nagy Nancy Slipp Kinsey Beck Christina Catley Ezra Hart Source Type: research
