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Topical Roflumilast for Plaque Psoriasis
Skin Therapy Lett. 2023 Sep;28(5):1-4.ABSTRACTRoflumilast is a highly selective phosphodiesterase-4 inhibitor for the treatment of plaque psoriasis. Topical roflumilast 0.3% cream, approved by the US FDA and Health Canada for use in adolescents and adults, has proven efficacy and tolerability. It is non-steroidal, administered once-daily, and highly potent, with a unique delivery formulation. It can be used on most body areas, including the sensitive intertriginous regions and face. Herein, we review the safety and efficacy of roflumilast 0.3% cream, as demonstrated in clinical trials.PMID:37734074
Source: Skin Therapy Letter - September 21, 2023 Category: Dermatology Authors: Ashley O'Toole Melinda Gooderham Source Type: research
Airway distortion in mucopolysaccharidosis
Can J Anaesth. 2023 Sep 20. doi: 10.1007/s12630-023-02578-0. Online ahead of print.NO ABSTRACTPMID:37730897 | DOI:10.1007/s12630-023-02578-0
Source: Canadian Journal of Anaesthesia - September 21, 2023 Category: Anesthesiology Authors: Jun Honda Shiori Tanaka Takahiro Hakozaki Satoki Inoue Source Type: research
An examination of willingness to participate and willingness to pay for a universal school food program in the Canadian context
CONCLUSION: A cost shared program might be financially sustainable in Canada if community characteristics such as household food insecurity status, economic participation of women and average household size are kept in mind while determining the price of the program.PMID:37728040 | DOI:10.1017/S1368980023002070
Source: Public Health Nutrition - September 20, 2023 Category: International Medicine & Public Health Authors: Suvadra Datta Gupta Punam Pahwa Rachel Engler-Stringer Source Type: research
Reductions in inhaler greenhouse gas emissions by addressing care gaps in asthma and chronic obstructive pulmonary disease: an analysis
CONCLUSIONS: Our analysis shows that the carbon savings from addressing misdiagnosis and suboptimal disease control are comparable to those achievable by switching one in four patients to lower GHG-emitting therapeutic strategies. Behaviour change strategies required to achieve and sustain delivery of evidence-based real-world care are complex, but the added identified incentive of carbon footprint reduction may in itself prove to be a powerful motivator for change among providers and patients. This additional benefit can be leveraged in future behaviour change interventions.PMID:37730281 | PMC:PMC10510936 | DOI:10.1136/bmjresp-2023-001716
Source: Respiratory Care - September 20, 2023 Category: Respiratory Medicine Authors: Myriam Gagn é Aliki Karanikas Samantha Green Samir Gupta Source Type: research
Effect of transversus abdominis plane block on postoperative outcomes in gynecologic oncology patients managed on an Enhanced Recovery After Surgery pathway
CONCLUSIONS: Surgeon-administered TAP blocks were associated with decreased length of stay and post-operative opioid use in patients not receiving scheduled NSAIDs. This decrease in opioid use was not associated with any increase in average or maximum pain scores.PMID:37729808 | DOI:10.1016/j.ygyno.2023.09.003
Source: Gynecologic Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Kristin A Black Gregg Nelson Natalie Goucher Joshua Foley Sophia Pin Michael Chong Sunita Ghosh Steven P Bisch Source Type: research
Primary Care: An Ideal Setting for the Early Identification and Management of Nutrition-Related Issues
Can J Diet Pract Res. 2023 Sep 20:1. doi: 10.3148/cjdpr-2023-021. Online ahead of print.NO ABSTRACTPMID:37729430 | DOI:10.3148/cjdpr-2023-021
Source: Canadian Journal of Dietetic Practice and Research - September 20, 2023 Category: Nutrition Authors: Naomi Cahill Source Type: research
An examination of willingness to participate and willingness to pay for a universal school food program in the Canadian context
CONCLUSION: A cost shared program might be financially sustainable in Canada if community characteristics such as household food insecurity status, economic participation of women and average household size are kept in mind while determining the price of the program.PMID:37728040 | DOI:10.1017/S1368980023002070
Source: Public Health Nutrition - September 20, 2023 Category: International Medicine & Public Health Authors: Suvadra Datta Gupta Punam Pahwa Rachel Engler-Stringer Source Type: research
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy
Can J Physiol Pharmacol. 2023 Sep 20. doi: 10.1139/cjpp-2023-0083. Online ahead of print.ABSTRACTThe tumour is fully functional in the zone of action of immune mediators. Moreover, the tumour needs immune system mediators to survive. "Adaptation" refers to a tumour's ability to withstand the effect of harmful elements. This gives birth to a new form of antitumour therapy: blocking tumour adaptability pathways. In this review, we will look at (i) tumour adaptation mechanisms as a result of pro-tumour immunoediting, (ii) how understanding tumour-adaptive mechanisms has led to ideas for developing cancer immunotherapies, and ...
Source: Canadian Journal of Physiology and Pharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: I Yu Malyshev O P Budanova L V Kuznetsova Source Type: research
Experiences of Indigenous Patients Receiving Dialysis: Systematic Review of Qualitative Studies
CONCLUSIONS: Indigenous patients receiving dialysis experience inequities in healthcare which compounds existing accessibility issues caused by colonization. Improving the accessibility and cultural responsiveness of dialysis and kidney transplant services in collaboration with Indigenous stakeholders holds promise to enhance the experience of Indigenous patients receiving dialysis.PMID:37730171 | DOI:10.1053/j.ajkd.2023.07.014
Source: Rural Remote Health - September 20, 2023 Category: Rural Health Authors: Marianne Kerr Allison Jaure Jacqueline H Stephens Siah Kim Richard Cutler Brydee Cashmore Michelle Dickson Nicole Evangelidis Jaquelyne T Hughes Ieyesha Roberts Nicole Scholes-Robertson Victoria Sinka GradDip Jonathan C Craig Source Type: research
Exploring the Access and Use of Social Technologies by Older Adults in Support of Their Mental Health During the COVID-19 Pandemic: A Rapid Review
This study aimed to explore the accessibility, outcomes, and challenges of social technology use among community-dwelling older adults, older adults in long-term care, older adults with neurocognitive disorder, and older adults with pre-frailty and frailty, to help guide future research in this area. A rapid review was conducted, and articles were retrieved from four online databases, including Medline, AgeLine, EconLit and CINAHL, and grey literature from Google Scholar. Of the 131 articles retrieved, 24 were included in this review. The positive outcomes of social technology use include improved mental and physical healt...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Joelle R DesCh âtelets Asif R Khowaja Kristin Mechelse Henriette Koning Dominic Ventresca Source Type: research
Social Connectedness Between Family Caregivers and Older Adults Living in Long-Term Care Homes in the Context of COVID-19
Can J Aging. 2023 Sep 20:1-12. doi: 10.1017/S0714980823000351. Online ahead of print.ABSTRACTThe coronavirus disease (COVID-19) pandemic and resulting restrictions on physical access to long-term care homes culminated in health declines for older adults living there and their families. Knowledge gaps exist regarding maintaining social connectedness when physically separated. The study aimed to explore family members' perceptions of the impact that restrictions on physical access to long-term care homes had on the experience of social connectedness between family members and older adults living in long-term care. The method...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Anna Garnett Hannah Pollock Natalie Floriancic Kristin Prentice Lorie Donelle Carri Hand Abe Oudshoorn Yolanda Babenko-Mould Cheryl Forchuk Source Type: research
Exploring the Access and Use of Social Technologies by Older Adults in Support of Their Mental Health During the COVID-19 Pandemic: A Rapid Review
This study aimed to explore the accessibility, outcomes, and challenges of social technology use among community-dwelling older adults, older adults in long-term care, older adults with neurocognitive disorder, and older adults with pre-frailty and frailty, to help guide future research in this area. A rapid review was conducted, and articles were retrieved from four online databases, including Medline, AgeLine, EconLit and CINAHL, and grey literature from Google Scholar. Of the 131 articles retrieved, 24 were included in this review. The positive outcomes of social technology use include improved mental and physical healt...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Joelle R DesCh âtelets Asif R Khowaja Kristin Mechelse Henriette Koning Dominic Ventresca Source Type: research
Social Connectedness Between Family Caregivers and Older Adults Living in Long-Term Care Homes in the Context of COVID-19
Can J Aging. 2023 Sep 20:1-12. doi: 10.1017/S0714980823000351. Online ahead of print.ABSTRACTThe coronavirus disease (COVID-19) pandemic and resulting restrictions on physical access to long-term care homes culminated in health declines for older adults living there and their families. Knowledge gaps exist regarding maintaining social connectedness when physically separated. The study aimed to explore family members' perceptions of the impact that restrictions on physical access to long-term care homes had on the experience of social connectedness between family members and older adults living in long-term care. The method...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Anna Garnett Hannah Pollock Natalie Floriancic Kristin Prentice Lorie Donelle Carri Hand Abe Oudshoorn Yolanda Babenko-Mould Cheryl Forchuk Source Type: research
Effect of transversus abdominis plane block on postoperative outcomes in gynecologic oncology patients managed on an Enhanced Recovery After Surgery pathway
CONCLUSIONS: Surgeon-administered TAP blocks were associated with decreased length of stay and post-operative opioid use in patients not receiving scheduled NSAIDs. This decrease in opioid use was not associated with any increase in average or maximum pain scores.PMID:37729808 | DOI:10.1016/j.ygyno.2023.09.003
Source: Gynecologic Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Kristin A Black Gregg Nelson Natalie Goucher Joshua Foley Sophia Pin Michael Chong Sunita Ghosh Steven P Bisch Source Type: research
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy
Can J Physiol Pharmacol. 2023 Sep 20. doi: 10.1139/cjpp-2023-0083. Online ahead of print.ABSTRACTThe tumour is fully functional in the zone of action of immune mediators. Moreover, the tumour needs immune system mediators to survive. "Adaptation" refers to a tumour's ability to withstand the effect of harmful elements. This gives birth to a new form of antitumour therapy: blocking tumour adaptability pathways. In this review, we will look at (i) tumour adaptation mechanisms as a result of pro-tumour immunoediting, (ii) how understanding tumour-adaptive mechanisms has led to ideas for developing cancer immunotherapies, and ...
Source: Canadian Journal of Physiology and Pharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: I Yu Malyshev O P Budanova L V Kuznetsova Source Type: research
