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Total 15073 results found since Jan 2013.

Infrapopliteal calcification patterns in critical limb ischemia: diagnostic, pathologic and therapeutic implications in the search for the endovascular holy grail.
This article attempts to review the implications of the diverse pathologic patterns of calcium distribution in infrapopliteal vessels of CLI patients, on the diagnostic modalities, technological developments, and the evolution of therapeutic approaches to improve outcomes among these patients. A critical analysis of the currently available data is provided, pointing to the surprising omission on the role of calcium on outcomes, and future directions are discussed. Is infrapopliteal calcium a roadblock or the avenue towards new paths? Necessity remains the mother of invention. PMID: 28240525 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - February 26, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Mustapha JA, Diaz-Sandoval LJ, Saab F Tags: J Cardiovasc Surg (Torino) Source Type: research

Pre-clinical imaging for establishment and comparison of orthotopic non-small cell lung carcinoma: in search for models reflecting clinical scenarios.
Conclusion Our developed orthotopic NSCLC tumours have similarity with biological growth behaviour comparable to that seen in the clinic and could therefore be used as attractive models to study tumour biology and evaluate new therapeutic strategies. The use of human cancer cell lines facilitates testing of different genomic tumour profiles that may affect treatment outcomes. Advances in knowledge The combination of different imaging modalities to identify tumour growth with subsequent use in treatment planning and orthotopic transplantation techniques to develop initially single lesions to ultimate metastases pave the way...
Source: The British Journal of Radiology - September 14, 2018 Category: Radiology Authors: Aktar R, Dietrich A, Tillner F, Kotb S, Löck S, Willers H, Baumann M, Krause M, Bütof R Tags: Br J Radiol Source Type: research

Indocyanine Green Angiography in Breast Reconstruction: Utility, Limitations, and Search for Standardization
Conclusions: ICGA can reduce postoperative tissue loss and aid in intraoperative flap design and inset. Despite the benefits of ICGA, its technical use and interpretation have yet to be standardized, limiting its widespread acceptance.
Source: Plastic and Reconstructive Surgery – Global Open - March 1, 2020 Category: Cosmetic Surgery Tags: Original Articles Source Type: research

In search of optimal cardioplegia for minimally invasive valve surgery
Perfusion. 2021 Jun 3:2676591211012554. doi: 10.1177/02676591211012554. Online ahead of print.ABSTRACTCardioplegic solutions are used in cardiac surgery to achieve controlled cardiac arrest during operations, making surgery safer. Cardioplegia can either be blood or crystalloid based, with perceived pros and cons of each type. Whilst it is known that cardioplegia causes cardiac arrest, there is debate over which cardioplegic solution provides the highest degree of myocardial protection during arrest. Myocardial damage is measured post-operatively by biomarkers such as serum TnT, TnI or CK-MB. It is known that the outcomes ...
Source: Perfusion - June 3, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Sion Russell Salman Butt Hunaid A Vohra Source Type: research

Machine perfusion in liver transplantation
CONCLUSIONS: In situations where the decision has been made to transplant a liver donated after circulatory death or donated following brain death, end-ischaemic HOPE will provide superior clinically relevant outcomes compared with SCS alone. Specifically, graft survival is improved (high-certainty evidence), serious adverse events are reduced (moderate-certainty evidence), and in donors after circulatory death, clinically relevant ischaemic biliary complications are reduced (high-certainty evidence). There is no good evidence that NMP has the same benefits over SCS in terms of these clinically relevant outcomes. NMP does ...
Source: Cochrane Database of Systematic Reviews - September 12, 2023 Category: General Medicine Authors: Samuel J Tingle Joseph J Dobbins Emily R Thompson Rodrigo S Figueiredo Balaji Mahendran Sanjay Pandanaboyana Colin Wilson Source Type: research

Abstract 231: Portrayal of Inappropriate Use of Myocardial Perfusion Imaging on Social Media and the Worldwide Web Session Title: Abstract Poster Session II
Conclusion: Publicly available information on the internet and social media does not encourage unnecessary testing. Depending on the search term used, unnecessary testing may be commonly or rarely discouraged. Important topics related to nuclear MPI, such as radiation and alternative testing options are not widely discussed.
Source: Circulation: Cardiovascular Quality and Outcomes - February 26, 2016 Category: Cardiology Authors: Winchester, D. E., Baxter, D., Beyth, R. J. Tags: Session Title: Abstract Poster Session II Source Type: research

Body Composition and Body Weight Changes at Different Altitude Levels: A Systematic Review and Meta-Analysis
In conclusion, BW and body composition changes occur during sojourns at different altitudes. The mechanisms leading to these changes are manifold and the magnitude of change is, in addition to the individual adaptive response to hypoxia, greatly influenced by the AL, the duration of the stay, the level of physical activity and the nutritional intake. This review identifies at least two contrasting motivations for hypoxia exposure; the experience of high altitude mountaineering and the “therapeutic” effect of hypoxia (e.g., weight loss programs). This analytical review of published data highlights the notion t...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

Monitoring coagulation factors during surgery. A systematic review
CONCLUSIONS: Pharmacokinetic estimation could allow individual and standardized intraoperative dose adjustments to be conducted in patients with hemophilia. The development of specific population pharmacokinetic models for surgery, including those based on extended half- life factors, will allow an optimization of current treatments, potentially reducing factor consumption and hospital stays.PMID:35379115
Source: Farmacia Hospitalaria - April 5, 2022 Category: Drugs & Pharmacology Authors: Juan Eduardo Meg ías-Vericat Santiago Bonanad-Boix Mar ía Remedios Marqués-Miñana Jos é Luis Poveda-Andrés Source Type: research