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Total 225 results found since Jan 2013.

Immunoglobulin Glycosylation Effects in Allergy and Immunity
AbstractPurpose of ReviewThe aim of this review will be to familiarize the reader with the general area of antibody (Ab) glycosylation and to summarize the known functional roles of glycosylation and how glycan structure can contribute to various disease states with emphasis on allergic disease.Recent FindingsBoth immunoglobulin (Ig) isotype and conserved Fc glycosylation sites often dictate the downstream activity of an Ab where complexity and degree of glycosylation contribute to its ability to bind Fc receptors (FcRs) and activate complement. Most information on the effects of glycosylation center on IgG in cancer thera...
Source: Current Allergy and Asthma Reports - October 30, 2016 Category: Allergy & Immunology Source Type: research

Targeting Inflammation in Cancer-Related-Fatigue: A Rationale for Mistletoe Therapy as Supportive Care in Colorectal Cancer Patients.
Conclusion. The clinically used mistletoe medication (Iscador®Qu) is the first candidate to be included in a supportive care modus into chemo- or chemo-radiotherapy protocols for colorectal patients to improve CRF without discernable toxicities. PMID: 24766319 [PubMed - as supplied by publisher]
Source: Inflammation and Allergy Drug Targets - April 27, 2014 Category: Allergy & Immunology Authors: Bock PR, Hanisch J, Matthes H, Zanker KS Tags: Inflamm Allergy Drug Targets Source Type: research

Peptide vaccines for cancer therapy.
Authors: Cerezo D, Pena MJ, Mijares M, Martinez G, Blanca I, De Sanctis JB Abstract For around four decades, vaccines of different kinds have been developed to treat different types of cancer. However, promising results encountered in the early phase contrasted with the results recorded in clinical studies. Recent discoveries in the vaccine field, adjuvants and delivery systems, and antigen presentation have lead to new patented approaches. The current review is focused on general description of peptide vaccines involving cancer antigen presentation, specific immune response, cell death dependent pathways, and targ...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 4, 2015 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Construction of a Recombinant Phage-vaccine Capable of Reducing the Growth Rate of an Established LL2 Tumor Model.
In conclusion, EM-L2 displaying phage particles could be deemed as an encouraging strategy in contemporary cancer immunotherapy. PMID: 29908541 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2018 Category: Allergy & Immunology Authors: Asadi-Ghalehni M, Rasaee MJ, Namvar Asl N, Khosravani M, Rajabibazl M, Khalili S, Modjtahedi H, Sadroddiny E Tags: Iran J Allergy Asthma Immunol Source Type: research

Assessment of the Inhibitory Effects of Ficin-hydrolyzed Gelatin Derived from Squid (Uroteuthis duvauceli) on Breast Cancer Cell Lines and Animal Model.
Abstract Marine novel natural products have been applied for cancer therapy. Enzyme-digested gelatin hydrolysates have proven to serve as promising sources of potent biologically active peptides. Potential anti-breast cancer properties of the extracted Ficin-digesterd gelatin hydrolysate from Indian squid (Uroteuthis duvauceli) was extensively characterized by cellular and animal models. Gelatin was extracted from squid skin, hydrolyzed by Ficin, and characterized by standard physico-chemical methods. Ficin-digested gelatin hydrolysate was used at various doses of 0-0.1 mg/mL for assessment of MCF-7 and MDA-MB-231...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 14, 2018 Category: Allergy & Immunology Authors: Shahidi S, Jamili S, Ghavam Mostafavi P, Rezaie S, Khorramizadeh M Tags: Iran J Allergy Asthma Immunol Source Type: research

Probing into Therapeutic Anti-cancer Potential of Apigenin: Recent Trends and Future Directions.
CONCLUSION: Studies related to the anti-inflammatory and anticancer potential of apigenin have been explored through this review article. Moreover, the patent analysis of apigenin has further strengthened its therapeutic role. Probing into the therapeutic properties of apigenin, further add value to this molecule in terms of its down regulation of major inflammatory and cancer associated signaling pathways. The article simultaneously would assist the scientific community to precisely understand the role of apigenin and design novel anti-cancer therapies. PMID: 31418666 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - August 17, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Immunogenicity Evaluation of Recombinant Edible Vaccine Candidate Containing HER2-MUC1 against Breast Cancer.
In this study, Her2, MUC1, and a novel fusion structure were expressed in the seeds and hairy roots of transgenic plants appropriately. The mice groups were immunized either by feeding of transgenic seeds or hairy roots. All immunized groups showed a considerable rise in anti-glycoprotein serum IgG and IgA, and IFNɣ cytokine. However, the animals received chimeric protein showed significant higher immune responses in comparison to ones received one of these immunogen. The results indicated that the oral immunization of an animal model with transgenic plants could effectively elicit immune responses against two major tumo...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 22, 2019 Category: Allergy & Immunology Authors: Mehrab Mohseni M, Amani J, Fasihi Ramandi M, Mahjoubi F, Jafaria M, Salmanian AH Tags: Iran J Allergy Asthma Immunol Source Type: research

SDF-1 α Reduces Human Natural Killer Cell Cytotoxicity against Chronic Myelogenous Leukemia K562 Cells.
SDF-1α Reduces Human Natural Killer Cell Cytotoxicity against Chronic Myelogenous Leukemia K562 Cells. Iran J Allergy Asthma Immunol. 2019 Oct 23;18(5):493-500 Authors: Mardomi A, Hossein-Nataj H, Jafari N, Mohammadi N, Abediankenari S Abstract Stromal cell-derived factor-1 alpha (SDF-1α) has been shown to be up-regulated in a variety of malignancies. So that, its expression is associated with poor prognosis and invasiveness. Natural killer (NK) cells are important effector cells against virus-infected and transformed cells. Especially they play a key role in tumor immune surveillance. Whereas it wa...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 22, 2019 Category: Allergy & Immunology Authors: Mardomi A, Hossein-Nataj H, Jafari N, Mohammadi N, Abediankenari S Tags: Iran J Allergy Asthma Immunol Source Type: research

Epigallocatechin-3-gallate Enhances the Efficacy of MicroRNA-34a Mimic and MicroRNA-93 Inhibitor Co-transfection in Prostate Cancer Cell Line.
Abstract The potential role of microRNAs (miRNA or MIR) as therapeutic molecules has moved them from basic research to the field of cancer therapy. High expression of miR-93 and low expression of miR-34a have previously been indicated in prostate cancer (PC), which is the second leading cause of cancer-related death in men. Androgen receptor (AR) and prostate-specific antigen (PSA) play key roles in the initiation and progression of this cancer. Therefore, this study aimed to investigate the effects of the transfection and co-transfection of miR-34a mimic and miR-93 inhibitor with or without epigallocatechin-3-gal...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2020 Category: Allergy & Immunology Authors: Mokhtari H, Yaghmaei B, Sirati-Sabet M, Jafari N, Mardomi A, Abediankenari S, Mahrooz A Tags: Iran J Allergy Asthma Immunol Source Type: research

Combination of 5-fluorouracil and Lipopolysaccharide Synergistically Induces Cytotoxicity and Apoptosis in MCF-7 Human Breast Cancer Cells.
Abstract Several studies have been conducted to find suitable combinations of drugs to increase the efficacy of chemotherapy and reduce the resistance of tumor cells to treatment. Lipopolysaccharide (LPS), as a ligand for Toll-like receptor 4 (TLR-4), can modify immune responses in different cancers. Although multiple studies have been performed in this area, the effect of LPS on tumor cells remains controversial. In the present study, the cytotoxic effects of 5-fluorouracil (5-FU), with or without LPS, were evaluated in human breast cancer cell line (MCF-7) on apoptosis and gene expression in downstream signaling...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 25, 2020 Category: Allergy & Immunology Authors: Nokhandani N, Naghavi Alhosseini M, Memarian A, Davoodi H Tags: Iran J Allergy Asthma Immunol Source Type: research

Low Noncytotoxic Concentrations of 5-Fluorouracil Have No Adverse Effects on Maturation and Function of Bone Marrow-Derived Dendritic Cells in vitro: A Potentially Safe Adjuvant for Dendritic Cell-Based Cancer Therapy
Conclusions: These data suggest that low doses of 5-FU have no adverse effects on DC maturation and function, and the efficacy of DC-based cancer immunotherapy may be greatly enhanced by combining it with suboptimal doses of 5-FU.Int Arch Allergy Immunol 2015;168:122-130
Source: International Archives of Allergy and Immunology - December 18, 2015 Category: Allergy & Immunology Source Type: research

Epigallocatechin-3-gallate Enhances the Efficacy of MicroRNA-34a Mimic and MicroRNA-93 Inhibitor Co-transfection in Prostate Cancer Cell Line
Iran J Allergy Asthma Immunol. 2020 Dec 19;19(6):612-623. doi: 10.18502/ijaai.v19i6.4930.ABSTRACTThe potential role of microRNAs (miRNA or MIR) as therapeutic molecules has moved them from basic research to the field of cancer therapy. High expression of miR-93 and low expression of miR-34a have previously been indicated in prostate cancer (PC), which is the second leading cause of cancer-related death in men. Androgen receptor (AR) and prostate-specific antigen (PSA) play key roles in the initiation and progression of this cancer. Therefore, this study aimed to investigate the effects of the transfection and co-transfecti...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 19, 2021 Category: Allergy & Immunology Authors: Hossein Mokhtari Bahram Yaghmaei Majid Sirati-Sabet Narjes Jafari Alireza Mardomi Saeid Abediankenari Abdolkarim Mahrooz Source Type: research

Combination of 5-fluorouracil and Lipopolysaccharide Synergistically Induces Cytotoxicity and Apoptosis in MCF-7 Human Breast Cancer Cells
Iran J Allergy Asthma Immunol. 2020 Aug 25;19(4):426-436. doi: 10.18502/ijaai.v19i4.4117.ABSTRACTSeveral studies have been conducted to find suitable combinations of drugs to increase the efficacy of chemotherapy and reduce the resistance of tumor cells to treatment. Lipopolysaccharide (LPS), as a ligand for Toll-like receptor 4 (TLR-4), can modify immune responses in different cancers. Although multiple studies have been performed in this area, the effect of LPS on tumor cells remains controversial. In the present study, the cytotoxic effects of 5-fluorouracil (5-FU), with or without LPS, were evaluated in human breast ca...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 19, 2021 Category: Allergy & Immunology Authors: Negin Nokhandani Mahdieh Naghavi Alhosseini Ali Memarian Homa Davoodi Source Type: research

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