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The Critical Role of Prenatal Genetic Study in Prevention of Primary Immunodeficiency in High-risk Families: The Largest Report of 107 Cases
This study aims to investigate the role of prenatal diagnosis (PND) in Iranian couples with a previous history of primary immunodeficiency disorders (PIDD) in their family. All referred couples with a family history of PIDD and a tendency for PND were included in this project. Based on gestational age, chorionic villus sampling (CVS) was performed to analyze the molecular defect of the fetus according to the previous gene defect of the affected case in the family. Postnatal confirmation was performed by immunological screening tests. In a total of 100 cases, CVS was not evaluated in 19 patients due to unwillingness (n=5), ...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 19, 2021 Category: Allergy & Immunology Authors: Seyedeh Zalfa Modarresi Nastaran Sabetkish Mohsen Badalzadeh Shaghayegh Tajik Behnaz Esmaeili Mohammad Reza Fazlollahi Massoud Houshmand Jaber Gharehdaghi Shirin Niroomanesh Fatemeh Rahimi Sherbaf Zahra Alizadeh Nazanin Khodayari Namini Marzieh Maddah Zah Source Type: research

mRNA Technology Gave Us the First COVID-19 Vaccines. It Could Also Upend the Drug Industry
“No!” The doctor snapped. “Look at me!” I had been staring her in the eyes, as she had ordered, but when a doctor on my other side began jabbing me with a needle, I started to turn my head. “Don’t look at it,” the first doctor said. I obeyed. This was in early August in New Orleans, where I had signed up to be a participant in the clinical trial for the Pfizer-BioNTech COVID-19 vaccine. It was a blind study, which meant I was not supposed to know whether I had gotten the placebo or the real vaccine. I asked the doctor if I would really been able to tell by looking at the syringe. &...
Source: TIME: Health - January 11, 2021 Category: Consumer Health News Authors: Walter Isaacson Tags: Uncategorized COVID-19 feature Magazine Source Type: news

Summary of COVID-19 medicines guidance: Allergy and immunology, Specialist Pharmacy Service (published 6th January 2021)
This page summarises and signposts to medicine related guidance we ' re aware of from professional and government bodies relating to coronavirus and allergy and immunology conditions.
Source: Current Awareness Service for Health (CASH) - January 7, 2021 Category: Consumer Health News Source Type: news

Fueled by a History of Mistreatment, Black Americans Distrust the New COVID-19 Vaccines
When a COVID-19 vaccine becomes widely available to Americans, Brianna Clarke says she won’t be taking it. “I don’t trust the vaccine,” the 22-year-old says. “I think it’s too soon to have a vaccine.” Clarke, who lives in Willingboro, N.J., is among a significant number of Black Americans who are skeptical of the healthcare industry in general and, critically, the COVID-19 vaccines recently developed by pharmaceutical companies Pfizer-BioNTech and Moderna, more specifically. Over the past couple of weeks, the U.S. has averaged in the neighborhood of 200,000 new COVID-19 cases per d...
Source: TIME: Health - December 28, 2020 Category: Consumer Health News Authors: Dezimey Kum Tags: Uncategorized COVID-19 Source Type: news

Moderna Requests Emergency FDA Authorization for COVID-19 Vaccine
Moderna is requesting emergency authorization from the Food and Drug Administration (FDA) for its COVID-19 vaccine on Monday — a development the company’s president tells TIME is an “incredible milestone.” The filing for the company’s mRNA-based vaccine is the first step toward getting the shot into hospitals, pharmacies and health centers. The Massachusetts-based biotech is the second company, following Pfizer, to request authorization for a COVID-19 vaccine. Unlike Pfizer’s shot, which is also based on mRNA, Moderna’s vaccine does not need to be stored at ultra cold temperatures ...
Source: TIME: Health - November 30, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 News overnight Source Type: news

Yes, We Have COVID-19 Vaccines That Are 95% Effective. But That Doesn ’t Mean the End of the Pandemic is Near
It’s a rare glimmer of hope in a brutal and battering pandemic year: in November, both Moderna and Pfizer reported that their much-anticipated COVID-19 vaccines are 95% effective in protecting people against getting sick with the disease. Scientists were encouraged (and even surprised by the magnitude of the protection), public health officials finally saw what could be the beginning of the end of the pandemic, and families everywhere began fantasizing about a return to normalcy where gathering around the table to celebrate the holidays are a given and not a matter of public health concern. But the same public health...
Source: TIME: Health - November 20, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

COVID-19 Vaccines Are Coming. Here ’s What to Expect
Vaccines normally take decades to develop and test, but two COVID-19 shots, from Moderna and Pfizer (in partnership with BioNTech), have gone from nonexistent to about 95% effectiveness in 10 months. Public-health officials and governments now have the dual challenge of convincing the public that the vaccines are both safe and scientifically sound, as well as figuring out how to distribute billions of doses. Here’s what we know so far about how that’s going. When can I get vaccinated? That depends. Manufacturers have already begun producing vaccines, betting that they will be effective, so they can be ready to ...
Source: TIME: Science - November 19, 2020 Category: Science Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

Moderna ’s COVID-19 Vaccine Is 94.5% Effective. Here’s What That Really Means
It’s wasn’t a typical Sunday morning for Dr. Stephen Hoge, president of the biotech company Moderna, and Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases. They were at their respective homes in Massachusetts and Washington, D.C., waiting to to be let into a Zoom call to hear the results of the very first COVID-19 vaccine that was tested in people. The hosts were members of the independent Data Safety Monitoring Board (DSMB) that is reviewing data involving all the COVID-19 vaccine candidates supported by the U.S. government’s Operation Warp Speed program, and Hoge a...
Source: TIME: Health - November 17, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

Diagnosis of primary immunodeficiencies in Peru
Purpose of review Primary immunodeficiencies (PIDs) are human inborn errors of immunity, leading to an increased susceptibility to infections, inflammatory manifestations, and malignancy. We estimate around 16 000 individuals with PIDs living in Peru who are still undiagnosed. The purpose of this review is to make a situational analysis of the diagnosis of PIDs in Peru. Recent findings There is an evident underdiagnosis of PIDs in Peru. Insufficient awareness and lack of diagnostic tools can be solved partially by expanding the number and expertise of Clinical Immunologists and specialized medical centers. The...
Source: Current Opinion in Pediatrics - November 11, 2020 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research

The Covid Pandemic: Broadening the Discourse
Thailand’s COVID-19 response an example of resilience and solidarity: a UN Resident Coordinator’s BlogBy Asoka BandarageCOLOMBO, Sri Lanka, Nov 10 2020 (IPS) SARS-CoV-2, the corona virus that causes COVID-19, has been spreading exponentially across the world over the last ten or so months. As of November 6th, according to the Center for Systems Science at Johns Hopkins University, there have been 49,195,581 cases of COVID-19, including 1,241,031 deaths. More than a third of the global population has been placed on lockdown. The global economy is experiencing the deepest global recession since World War 2 and massive n...
Source: IPS Inter Press Service - Health - November 10, 2020 Category: International Medicine & Public Health Authors: Asoka Bandarage Tags: Featured Global Headlines Health Human Rights Humanitarian Emergencies Peace TerraViva United Nations Source Type: news