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Therapy: Immunotherapy
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Total 891 results found since Jan 2013.
We are memory: B cell responses in allergy and tolerance
This article is protected by copyright. All rights reserved.PMID:37098972 | DOI:10.1002/eji.202048916
Source: European Journal of Immunology - April 26, 2023 Category: Allergy & Immunology Authors: Wolfgang Pf ützner Alexandra Polakova Christian M öbs Source Type: research
Anti-IgE for food allergy
CONCLUSIONS: Over the past 20 years, significant progress has been made in understanding the potential role of anti-IgE therapies for food allergy. Anti-IgE therapies appear to be a promising option that may increase reaction dose thresholds and decrease time to reach OIT maintenance and OIT dosing related reactions. Two Phase III trials are currently in progress studying anti-IgE potential monotherapy for the treatment of peanut and multi-food allergies. It is important for clinicians to be aware of these emerging treatment options.PMID:37031775 | DOI:10.1016/j.anai.2023.03.030
Source: Annals of Allergy, Asthma and Immunology - April 9, 2023 Category: Allergy & Immunology Authors: Jennifer A Dantzer Robert A Wood Source Type: research
Food Allergy
Food allergy is a growing health problem affecting both pediatric and adult patients. Food allergies are often immunoglobulin E (IgE) mediated but other food-induced non –IgE-mediated diseases exist. Diagnosis of food allergy relies on the combination of clinical and reaction history, skin and IgE testing as well as oral food challenges. Although oral immunotherapy has been able to achieve sustained unresponsiveness in some patients, no cure for food allergies has been found to date. Avoidance of the inciting food as well as availability of epinephrine autoinjectors remains the mainstay of treatment.
Source: Primary Care: Clinics in Office Practice - March 27, 2023 Category: Primary Care Authors: Chelsea Elizabeth Mendonca, Doerthe A. Andreae Source Type: research
Microneedle array patches for allergen-specific immunotherapy
Drug Discov Today. 2023 Mar 15:103556. doi: 10.1016/j.drudis.2023.103556. Online ahead of print.ABSTRACTThe incidence of allergies has been steadily increasing in recent years. Allergen-specific immunotherapy (AIT) represents the only approach capable of inducing long-term immune tolerance toward allergens. However, the clinical success of AIT is limited by efficacy or safety concerns related to the administration route. Therapeutic delivery in the skin appears promising, given the presence of immune cells in the skin and the relatively low level of systemic distribution that occurs with this delivery method {AuQ: Edit OK?...
Source: Drug Discovery Today - March 17, 2023 Category: Drugs & Pharmacology Authors: Juan L Paris Lalitkumar K Vora Mar ía José Torres Cristobalina Mayorga Ryan F Donnelly Source Type: research
Is it time to set the alarmins as potential targets in food allergy?
Food allergies affect an estimated 8% of children, and up to 10% of adults in the United States, and prevalence is increasing over time. 1,2 While primary prevention through early exposure is of utmost importance, there is a substantial need for disease-modifying therapies. Food allergy treatment is an active area of research, particularly in the last several years, leading to the FDA-approval of the first product for this purpose, Palforzia (Aimmune Therapeutics, Brisbane, CA), for peanut oral immunotherapy (OIT) in 2020.
Source: Annals of Allergy, Asthma and Immunology - March 9, 2023 Category: Allergy & Immunology Authors: Amber N. Pepper, Thomas B. Casale Source Type: research
Evolution Of Immunotherapy Against Pollen Allergy
Curr Protein Pept Sci. 2023 Mar 3. doi: 10.2174/1389203724666230303091754. Online ahead of print.ABSTRACTAllergic diseases have increased worldwide during the last century and are a major disease burden globally. Several substances can induce allergic sensitization and elicit allergic symptoms in sensitized individuals. Pollen grains are one of the main causes of allergic rhinitis and asthma, and the prevalence of different pollen species depends on the climate, geographical regions, flora, and season. In addition to avoiding exposure to pollens, anti-allergic drugs are commonly used to mitigate the symptoms of allergies. ...
Source: Current Protein and Peptide Science - March 5, 2023 Category: Biochemistry Authors: Mistrello Gianni Source Type: research
