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Total 493 results found since Jan 2013.

Pathogenic Mechanism and Diagnostic Testing for Drug Allergies.
Abstract 　Three stages of the pathogenic mechanism of drug allergies can be considered: antigen formation, immune reaction and inflammation/disorder reaction. Drugs are thought to form 4 types of antigens: drug only, polymers, drug-carrier conjugates, and metabolite-carrier complexes. Antigens are recognized by B cell receptors and T cell receptors. Helper T cells (Th) are differentiated into four subsets, namely, Th1, Th2, Th17 and regulatory T cells (Treg). Th1 produces interleukin (IL)-2 and interferon (IFN)-γ, and activates macrophages and cytotoxic T cells (Tc). Macrophages induce type IV allergies, and Tc...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 3, 2018 Category: Drugs & Pharmacology Authors: Uno K Tags: Yakugaku Zasshi Source Type: research

Assessment of Opioid Cross-reactivity and Provider Perceptions in Hospitalized Patients With Reported Opioid Allergies.
Conclusions: The risk of IMRs caused by opioids is low in patients with H-IMRs to opioids. Opioid allergy documentations may propagate alert fatigue and unwarranted prescribing changes. PMID: 31253049 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - June 27, 2019 Category: Drugs & Pharmacology Authors: Powell MZ, Mueller SW, Reynolds PM Tags: Ann Pharmacother Source Type: research

Factors Associated with Self-Reported Drug Allergies in a Large Chronic Spontaneous Urticaria Cohort.
CONCLUSION: In CSU, the prevalence of self-reported drug allergies was higher than the general population. Drug allergy associated with older age, white race and higher BMI while multiple drug allergy also associated with asthma. These CSU sub-populations should be studied to avoid the potential for morbidity associated with less efficacious and more costly drugs. PMID: 33006537 [PubMed - as supplied by publisher]
Source: Current Drug Safety - October 1, 2020 Category: Drugs & Pharmacology Authors: Rauscher C, Petrov AA, Fajt ML Tags: Curr Drug Saf Source Type: research

Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis.
Abstract The current definition of allergy is a group of IgE-mediated diseases. However, a large portion of patients with clinical manifestations of allergies do not exhibit elevated serum levels of IgE (sIgEs). In this article, three key factors, i.e. soluble allergens, sIgEs and mast cells or basophils, representing the causative factors, messengers and primary effector cells in allergic inflammation, respectively, were discussed. Based on current knowledge on allergic diseases, we propose that allergic diseases are a group of diseases mediated through activated mast cells and/or basophils in sensitive individua...
Source: Acta Pharmacologica Sinica - August 26, 2013 Category: Drugs & Pharmacology Authors: He SH, Zhang HY, Zeng XN, Chen D, Yang PC Tags: Acta Pharmacol Sin Source Type: research

Vaccines as therapies for food allergies
Adv Pharmacol. 2021;91:229-258. doi: 10.1016/bs.apha.2021.01.003. Epub 2021 Mar 4.ABSTRACTFood allergy is a growing public health epidemic with few available treatments beyond allergen avoidance and rescue medications for accidental exposures. A major focus of therapeutic development for food allergies is allergen-specific immunotherapy (AIT) in which patients are exposed to increasing amounts of allergen in controlled dosing to induce desensitization or tolerance. The work of the past few decades has culminated in the recent FDA approval of a peanut product for oral AIT for peanut allergies. Despite these advances, curren...
Source: Advances in Pharmacology - June 8, 2021 Category: Drugs & Pharmacology Authors: Jeffrey J Landers Jessica J O'Konek Source Type: research