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Total 11041 results found since Jan 2013.

Montelukast as a potential treatment for COVID-19
Expert Opin Pharmacother. 2023 Mar 16. doi: 10.1080/14656566.2023.2192866. Online ahead of print.ABSTRACTINTRODUCTION: : Montelukast is a leukotriene inhibitor that is widely used to treat chronic asthma and allergic rhinitis. The drug interferes with molecular signaling pathways produced by leukotrienes in a variety of cells and tissues throughout the human body that lead to tightening of airway muscles, production of aberrant pulmonary fluid (airway edema), and in some cases, pulmonary inflammation.AREAS COVERED: : Montelukast has also been noted to have anti-inflammatory properties, suggesting it may have a role in the ...
Source: Expert Opinion on Pharmacotherapy - March 17, 2023 Category: Drugs & Pharmacology Authors: Matthew W McCarthy Source Type: research

Comparing the clinical and cost-effectiveness of remote (telehealth and online) cognitive behavioral therapy-based treatments for high-impact chronic pain relative to usual care: study protocol for the RESOLVE multisite randomized control trial
DISCUSSION: This large-scale trial provides a unique opportunity to rigorously evaluate and compare the clinical and cost-effectiveness of 2 relatively low-cost and scalable modalities for providing CBT-CP-based treatments to persons with high-impact chronic pain, including those residing in rural and other medically underserved areas with limited access to these services.TRIAL REGISTRATION: ClinicalTrials.gov NCT04523714. This trial was registered on 24 August 2020.PMID:36927459 | PMC:PMC10018633 | DOI:10.1186/s13063-023-07165-8
Source: Rural Remote Health - March 17, 2023 Category: Rural Health Authors: Meghan Mayhew Benjamin H Balderson Andrea J Cook John F Dickerson Charles R Elder Alison J Firemark Irina V Haller Morgan Justice Francis J Keefe Carmit K McMullen Maureen C O'Keeffe-Rosetti Ashli A Owen-Smith Christine Rini Jennifer L Schneider Michael V Source Type: research

Categorising implementation determinants and strategies within the US HIV implementation literature: a systematic review protocol
Introduction Despite decreased rates of new infections, HIV/AIDS continues to impact certain US populations. In order to achieve the goals laid out in the Ending the HIV Epidemic (EHE) in the US initiative, implementation science is needed to expand the sustained use of effective prevention and treatment interventions, particularly among priority populations at risk for and living with HIV/AIDS. Over 200 HIV-related implementation studies have been funded by the US National Institutes of Health. Therefore, a comprehensive review of the literature identifying implementation determinants (barriers and facilitators) and categ...
Source: BMJ Open - March 16, 2023 Category: General Medicine Authors: Merle, J. L., Li, D., Keiser, B., Zamantakis, A., Queiroz, A., Gallo, C. G., Villamar, J. A., McKay, V., Zapata, J. P., Mustanski, B., Benbow, N., Smith, J. D. Tags: Open access HIV/AIDS Source Type: research

Rigor, Reproducibility, and Transparency in Shared Research Resources: Follow-Up Survey and Recommendations for Improvements
J Biomol Tech. 2022 Aug 16;33(3):3fc1f5fe.fa789303. doi: 10.7171/3fc1f5fe.fa789303. eCollection 2022 Oct 15.ABSTRACTRigor, reproducibility, and transparency (RR&T) are essential components of all scientific pursuits. Shared research resources, also known as core facilities, are on the frontlines of ensuring robust RR&T practices. The Association of Biomolecular Resource Facilities Committee on Core Rigor and Reproducibility conducted a follow-up survey 4 years after the initial 2017 survey to determine if core facilities have seen a positive impact of new RR&T initiatives (including guidance from the National I...
Source: Journal of Biomolecular Techniques : JBT - March 13, 2023 Category: Molecular Biology Authors: Andrew W Ott Katia Sol-Church Gauravi M Deshpande Kevin L Knudtson Susan M Meyn Sheenah M Mische Douglas J Taatjes Michael R Sturges Christopher W Gregory Source Type: research