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Nutrition: Zinc
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Effect of water-soluble zinc porphyrin on the catalytic activity of fumarase for L-malate dehydration to fumarate
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Mika Takeuchi, Yutaka Amao Fumarase from porcine heart (FUM; EC 4.2.1.2) is an enzyme that dehydrates L-malate in an aqueous medium to catalyze fumarate production. In the visible-light driven NADH regeneration with the system... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - September 7, 2023 Category: Chemistry Authors: Mika Takeuchi Source Type: research
Multilayer precision-based screening of potential inhibitors targeting Mycobacterium tuberculosis acetate kinase using in silico approaches
Comput Biol Chem. 2023 Aug 23;107:107942. doi: 10.1016/j.compbiolchem.2023.107942. Online ahead of print.ABSTRACTTuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a major threat to global health, with the emergence of multi-drug and extensively drug-resistant strains posing a serious challenge. Thereby, understanding the molecular basis of MTB virulence and disease pathogenesis is critical for developing effective therapeutic strategies. Targeting proteins involved in central metabolism has been recognized as a promising therapeutic approach to combat MTB. In this regard, the enzyme AckA of the acetate...
Source: Computational Biology and Chemistry - September 6, 2023 Category: Bioinformatics Authors: Sneha Subramaniyan Hemavathy Nagarajan Umashankar Vetrivel Jeyakanthan Jeyaraman Source Type: research
Trimethylsilyl Chloride Aids in Solubilization of Oxidative Addition Intermediates from Zinc Metal
Angew Chem Int Ed Engl. 2023 Sep 6:e202307787. doi: 10.1002/anie.202307787. Online ahead of print.ABSTRACTTrimethylsilyl chloride (TMSCl) is commonly used to "activate" metal(0) powders toward oxidative addition of organohalides, but knowledge of its mechanism remains limited by the inability to characterize chemical intermediates under reaction conditions. Here, fluorescence lifetime imaging microscopy (FLIM) overcomes these prior limitations and shows that TMSCl aids in solubilization of the organozinc intermediate from zinc(0) metal after oxidative addition, a previously unknown mechanistic role. This mechanistic role i...
Source: Angewandte Chemie - September 6, 2023 Category: Chemistry Authors: Erin M Hanada Patrick J McShea Suzanne A Blum Source Type: research
Multilayer precision-based screening of potential inhibitors targeting Mycobacterium tuberculosis acetate kinase using in silico approaches
Comput Biol Chem. 2023 Aug 23;107:107942. doi: 10.1016/j.compbiolchem.2023.107942. Online ahead of print.ABSTRACTTuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a major threat to global health, with the emergence of multi-drug and extensively drug-resistant strains posing a serious challenge. Thereby, understanding the molecular basis of MTB virulence and disease pathogenesis is critical for developing effective therapeutic strategies. Targeting proteins involved in central metabolism has been recognized as a promising therapeutic approach to combat MTB. In this regard, the enzyme AckA of the acetate...
Source: Computational Biology and Chemistry - September 6, 2023 Category: Bioinformatics Authors: Sneha Subramaniyan Hemavathy Nagarajan Umashankar Vetrivel Jeyakanthan Jeyaraman Source Type: research
Protective effects of macromolecular polyphenols, metal (zinc, selenium, and copper) - Polyphenol complexes, and pectin in different organs with an emphasis on arsenic poisoning: A review
Int J Biol Macromol. 2023 Sep 4:126715. doi: 10.1016/j.ijbiomac.2023.126715. Online ahead of print.ABSTRACTFor the potential health benefits and nutritional value, polyphenols are one of the secondary metabolites of plants that have received extensive research. It has anti-inflammatory and cytotoxicity-reducing properties in addition to a high antioxidant content. Macromolecular polyphenols and polysaccharides are biologically active natural polymers with antioxidant and anti-inflammatory potential. Arsenic is an ecologically toxic metalloid. Arsenic in drinking water is the most common way people come into contact with th...
Source: Cancer Control - September 6, 2023 Category: Cancer & Oncology Authors: Kaviyarasi Renu Anirban Goutam Mukherjee Abilash Valsala Gopalakrishnan Uddesh Ramesh Wanjari Sandra Kannampuzha Reshma Murali Vishnu Priya Veeraraghavan Sathishkumar Vinayagam Soraya Paz-Montelongo Alex George Balachandar Vellingiri Harishkumar Madhyasth Source Type: research
Synthesis of metal-organic framework microrings via an anisotropic growth-etching approach
CrystEngComm, 2023, Accepted Manuscript DOI: 10.1039/D3CE00648D, PaperYue Zhang, Rong Deng, Ling Yuan, Chaoqi Zhang, Jing Wang, Chao Liu Design of metal-organic frameworks (MOFs) with elobrate structural features is of great siginicance for their applications with improved performances. In this work, we report the construction of unique zinc-based zeolite... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - CrystEngComm latest articles - September 6, 2023 Category: Chemistry Authors: Yue Zhang Source Type: research
Nickel Phosphonate MOF Derived N-doped Carbon-coated Phosphorus-vacancies-rich Ni2P Particles as Efficient Bifunctional Oxygen Electrocatalyst
Chemistry. 2023 Sep 5:e202302182. doi: 10.1002/chem.202302182. Online ahead of print.ABSTRACTThe design of non-noble metal bifunctional electrocatalysts with outstanding performance and remarkable stability for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is the most essential issue to the realization of rechargeable zinc-air battery and transition metal phosphides (TMPs) have emerged as robust candidates for oxygen electrocatalysts. Herein, N-doped carbon-coated phosphorus-vacancies-rich Ni2P particles (Vp-Ni2P@NC) is proposed via simple carbonization and following Ar plasma treatment from a single ...
Source: Chemistry - September 5, 2023 Category: Chemistry Authors: Xinjie Guo Chenhao Lv Yun Wang Tengfei Wang Xingyu Gan Liangjun Li Xiaoxia Lv Source Type: research
Valorization of a poultry industry floated sludge as a raw material to produce char and activated carbon for pharmaceutical compounds adsorption
This study was intended to valorize a floated sludge of a poultry slaughterhouse using it as a precursor to producing char and activated carbon, which were tested as adsorbents in removing ketoprofen and diclofenac sodium from the water. The addition of zinc chloride or calcium hydroxide was determinant for forming a porous carbonaceous structure with a high surface area in AC-FSP (656.54 m2 g-1), differently from that exhibited by the CHAR-FSP (8.11 m2 g-1). Kinetic and equilibrium studies indicated that the pseudo-second-order and the Sips models were suitable. The AC- FSP maximum adsorption capacity for ketoprofen and d...
Source: Environmental Science and Pollution Research International - September 5, 2023 Category: Environmental Health Authors: Patr ícia Grassi Ang élica Fátima Mantelli Streit Naushad Ahmad Asad Nawaz Luis Felipe Oliveira Silva Marcos Leandro Silva Oliveira Julia da Silveira Salla Ademir Gerhardt Gabriela Carvalho Collazzo S érgio Luiz Jahn Guilherme Luiz Dotto Source Type: research
Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease
J Cell Mol Med. 2023 Sep 5. doi: 10.1111/jcmm.17946. Online ahead of print.ABSTRACTParkinson's disease (PD) is a challenge because of the ageing of the population and the disease's complicated pathogenesis. Accumulating evidence showed that iron and autophagy were involved in PD. Nevertheless, the molecular mechanism and role of iron and autophagy in PD are not yet elucidated. In the present study, it was shown that PD mice had significant motor dysfunction, increased iron content, less dopamine neurons and more α-synuclein accumulation in the substantia nigra. Meanwhile, PD mice treated with deferoxamine exhibited less i...
Source: J Cell Mol Med - September 5, 2023 Category: Molecular Biology Authors: Yinying Wang Qian Wen Rongsha Chen Zhichao Gan Xinwei Huang Pengfei Wang Xia Cao Ninghui Zhao Zhongshan Yang Jinyuan Yan Source Type: research
