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Management of Paget-Schroetter Syndrome: a Systematic Review and Meta-Analysis
CONCLUSION: Non-operative management of PSS with AC alone results in persistent symptoms in 46% of patients, while 96% of patients managed with CDT + FFR are symptom free at end of follow up. Superiority of CDT + FRR compared with AC, CDT + AC, and AC + FRR was confirmed by meta-analysis. The overall quality of included reports was moderate, and the level of certainty was "very low".PMID:37678659 | DOI:10.1016/j.ejvs.2023.08.065
Source: PubMed: Eur J Vasc Endovasc ... - September 7, 2023 Category: Surgery Authors: Frank Hoexum Max Hoebink Hans M E Coveliers Willem Wisselink Vincent Jongkind Kak Khee Yeung Source Type: research
3D Printing-Assisted versus Conventional Extracorporeal Fenestration Tevar for Stanford Type B Arteries Dissection with Undesirable Proximal Anchoring Zone: Efficacy Analysis
CONCLUSIONS: Both techniques are safe and effective for TBAD with an undesirable proximal landing zone. The 3D-printing-assisted extracorporeal fenestration TEVAR technique has advantages in operative time, endoleak risk, and aortic remodeling, while the traditional extracorporeal fenestration TEVAR technique has advantages in stent modification.PMID:37679083 | DOI:10.59958/hsf.5885
Source: The Heart Surgery Forum - September 7, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Rongyi Zheng Fangtao Zhu Cunwei Cheng Weihua Huang Haojie Zhang Xin He Qianqian Lu Huayuan Xi Kailin Shen Haibin Yu Source Type: research
PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice
CONCLUSIONS: The PAR4 inhibitory RAG8 pepducin reduced coronary artery atherosclerosis and myocardial fibrosis in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet containing cholate. Furthermore, RAG8 reduced VCAM-1 in nonatherosclerotic coronary arteries and reduced leukocyte and platelet accumulation in atherosclerotic coronary arteries. These findings identify PAR4 as an attractive target in reducing coronary artery disease development, and the use of RAG8 may potentially be beneficial in cardiovascular disease.PMID:37675637 | DOI:10.1161/ATVBAHA.123.319767
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Samuel K Lee Rida Malik Ji Zhou Wei Wang Peter Gross Jeffrey Weitz Rithwik Ramachandran Bernardo L Trigatti Source Type: research
Angiogenesis Redux: An Overall Protective Role of VEGF/KDR Signaling in the Microvasculature in Pulmonary Arterial Hypertension
Arterioscler Thromb Vasc Biol. 2023 Sep 7. doi: 10.1161/ATVBAHA.123.319839. Online ahead of print.NO ABSTRACTPMID:37675636 | DOI:10.1161/ATVBAHA.123.319839
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Ying Zhong Paul B Yu Source Type: research
Transcriptomic Profiling Identifies Ferroptosis-Related Gene Signatures in Ischemic Muscle Satellite Cells Affected by Peripheral Artery Disease
CONCLUSIONS: This is the first report documenting that genes known to be involved in ferroptosis are differentially expressed in human skeletal muscle affected by PAD. Targeting ferroptosis may be a novel therapeutic strategy to reduce PAD myopathy.PMID:37675635 | DOI:10.1161/ATVBAHA.123.319518
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Lillian Tran Bowen Xie Edwyn Assaf Ricardo Ferrari Iraklis I Pipinos George P Casale Roberto Ivan Mota Alvidrez Simon Watkins Ulka Sachdev Source Type: research
Diversity of Megakaryocytes
Arterioscler Thromb Vasc Biol. 2023 Sep 7. doi: 10.1161/ATVBAHA.123.318782. Online ahead of print.ABSTRACTMegakaryocytes are commonly known as large, polyploid, bone marrow resident cells that contribute to hemostasis through the production of platelets. Soon after their discovery in the 19th century, megakaryocytes were described in tissue locations other than the bone marrow, specifically in the lungs and the blood circulation. However, the localization of megakaryocytes in the lungs and the contribution of lung megakaryocytes to the general platelet pool has only recently been appreciated. Moreover, the conception of me...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Florian Puhm Audr ée Laroche Eric Boilard Source Type: research
Unanticipated Enhancement of Intestinal TG Output by Apoc3 ASO Inhibition
CONCLUSIONS: Despite the marked reduction in plasma triglyceride concentration that occurs with apoC3 ASO inhibition, intestinal triglyceride output surprisingly increased rather than decreased. These data demonstrate that the reduction of intestinal triglyceride output does not contribute to the potent plasma triglyceride-lowering observed with this novel therapy for hypertriglyceridemia. Further studies are required to explore the mechanism of this intestinal effect.PMID:37675633 | DOI:10.1161/ATVBAHA.123.319765
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Majid Mufaqam Syed-Abdul Lili Tian Gary F Lewis Source Type: research
Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis
CONCLUSIONS: OxPAPC elicits Treg-specific changes altering Treg differentiation and inducing a Th1-like phenotype in surviving cells partially through IFN-γ signaling. This is biologically relevant as oxPAPC-treated Tregs do not reduce atherosclerosis progression in Ldlr-/- mice. This study supports the role of oxidized phospholipids in negatively impacting Treg differentiation and atheroprotective function.PMID:37675632 | DOI:10.1161/ATVBAHA.123.319674
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Brenna D Appleton Sydney A Palmer Harrison P Smith Lilly E Stephens Amy S Major Source Type: research
Angiogenesis Redux: An Overall Protective Role of VEGF/KDR Signaling in the Microvasculature in Pulmonary Arterial Hypertension
Arterioscler Thromb Vasc Biol. 2023 Sep 7. doi: 10.1161/ATVBAHA.123.319839. Online ahead of print.NO ABSTRACTPMID:37675636 | DOI:10.1161/ATVBAHA.123.319839
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Ying Zhong Paul B Yu Source Type: research
Transcriptomic Profiling Identifies Ferroptosis-Related Gene Signatures in Ischemic Muscle Satellite Cells Affected by Peripheral Artery Disease
CONCLUSIONS: This is the first report documenting that genes known to be involved in ferroptosis are differentially expressed in human skeletal muscle affected by PAD. Targeting ferroptosis may be a novel therapeutic strategy to reduce PAD myopathy.PMID:37675635 | DOI:10.1161/ATVBAHA.123.319518
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Lillian Tran Bowen Xie Edwyn Assaf Ricardo Ferrari Iraklis I Pipinos George P Casale Roberto Ivan Mota Alvidrez Simon Watkins Ulka Sachdev Source Type: research
Diversity of Megakaryocytes
Arterioscler Thromb Vasc Biol. 2023 Sep 7. doi: 10.1161/ATVBAHA.123.318782. Online ahead of print.ABSTRACTMegakaryocytes are commonly known as large, polyploid, bone marrow resident cells that contribute to hemostasis through the production of platelets. Soon after their discovery in the 19th century, megakaryocytes were described in tissue locations other than the bone marrow, specifically in the lungs and the blood circulation. However, the localization of megakaryocytes in the lungs and the contribution of lung megakaryocytes to the general platelet pool has only recently been appreciated. Moreover, the conception of me...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Florian Puhm Audr ée Laroche Eric Boilard Source Type: research
Unanticipated Enhancement of Intestinal TG Output by Apoc3 ASO Inhibition
CONCLUSIONS: Despite the marked reduction in plasma triglyceride concentration that occurs with apoC3 ASO inhibition, intestinal triglyceride output surprisingly increased rather than decreased. These data demonstrate that the reduction of intestinal triglyceride output does not contribute to the potent plasma triglyceride-lowering observed with this novel therapy for hypertriglyceridemia. Further studies are required to explore the mechanism of this intestinal effect.PMID:37675633 | DOI:10.1161/ATVBAHA.123.319765
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Majid Mufaqam Syed-Abdul Lili Tian Gary F Lewis Source Type: research
Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis
CONCLUSIONS: OxPAPC elicits Treg-specific changes altering Treg differentiation and inducing a Th1-like phenotype in surviving cells partially through IFN-γ signaling. This is biologically relevant as oxPAPC-treated Tregs do not reduce atherosclerosis progression in Ldlr-/- mice. This study supports the role of oxidized phospholipids in negatively impacting Treg differentiation and atheroprotective function.PMID:37675632 | DOI:10.1161/ATVBAHA.123.319674
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Brenna D Appleton Sydney A Palmer Harrison P Smith Lilly E Stephens Amy S Major Source Type: research
A bio-inspired nanoparticle coating for vascular healing and immunomodulatory by cGMP-PKG and NF-kappa B signaling pathways
Biomaterials. 2023 Aug 27;302:122288. doi: 10.1016/j.biomaterials.2023.122288. Online ahead of print.ABSTRACTDrug-eluting stents (DESs) implantation is an effective method to tackle in-stent restenosis (ISR), which has been considered as an efficient treatment for coronary atherosclerosis. Although fruitful results have been achieved in treating coronary artery diseases (CAD), concern has arisen regarding the long-term safety and efficacy of DESs, primarily due to adverse events such as delayed re-endothelialization, persistent inflammatory response, and late stent thrombosis (LST). Taking inspiration from the immunomodula...
Source: Biomaterials - September 7, 2023 Category: Materials Science Authors: Yanyan Li Bo Zhang Xiyu Liu Huining Wan Yumei Qin Hui Yan Yu Wang Yongqi An Yuan Yang Yan Dai Li Yang Yunbing Wang Source Type: research
Gas station in blood vessels: An endothelium mimicking, self-sustainable nitric oxide fueling stent coating for prevention of thrombosis and restenosis
Biomaterials. 2023 Aug 31;302:122311. doi: 10.1016/j.biomaterials.2023.122311. Online ahead of print.ABSTRACTStenting is the primary treatment for vascular obstruction-related cardiovascular diseases, but it inevitably causes endothelial injury which may lead to severe thrombosis and restenosis. Maintaining nitric oxide (NO, a vasoactive mediator) production and grafting endothelial glycocalyx such as heparin (Hep) onto the surface of cardiovascular stents could effectively reconstruct the damaged endothelium. However, insufficient endogenous NO donors may impede NO catalytic generation and fail to sustain cardiovascular h...
Source: Biomaterials - September 7, 2023 Category: Materials Science Authors: Jingdong Rao Xiaohui Mou Yongyi Mo Ho-Pan Bei Li Wang Chuyang Y Tang Kai-Hang Yiu Zhilu Yang Xin Zhao Source Type: research
