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Total 5398 results found since Jan 2013.
Commonly used fluoroquinolones cross-react with urine drug screens for opiates, buprenorphine, and amphetamines.
CONCLUSIONS: This study demonstrates that levofloxacin cross-reacts with modern immunoassays for two related opioids (buprenorphine and morphine) and moxifloxacin cross-reacts with the amphetamine/methamphetamine assay. Urine concentrations of these fluoroquinolones that are consistent with therapeutic use produced results above commonly used-cutoffs for positivity. This underscores the necessity of confirmatory testing of presumptively positive urine drug screens.
PMID: 30991036 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - April 12, 2019 Category: Biochemistry Authors: Colby JM, Patel PC, Fu DY, Rutherford NJ Tags: Clin Biochem Source Type: research
The search of potential inhibitors of the AcrAB-TolC system of multidrug-resistant Escherichia coli: an in silico approach.
Abstract
The number of infections caused by multidrug antibiotic resistance (MDR) species is increasing globally. The efflux pump system, AcrAB-TolC, confers Escherichia coli resistance to many antibiotics and results in poor treatment outcomes. Different rational drug design techniques were employed to search for a safe and effective AcrAB-TolC system inhibitor. Ligand docking was performed to analyze the binding of different ArcB substrates and/or inhibitors in the different AcrAB crystal structure binding sites. The validated docking site using the established docking preferences was used to perform virtual hig...
Source: Applied Microbiology and Biotechnology - June 16, 2019 Category: Microbiology Authors: Abdel-Halim H, Al Dajani A, Abdelhalim A, Abdelmalek S Tags: Appl Microbiol Biotechnol Source Type: research
Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids.
Abstract
A series of 1,2,4-triazole-based compounds was designed as potential antibacterial agents using molecular hybridization approach. The target compounds (23-44) were synthesized by Mannich reaction of 1,2,4-triazole-3-thione derivatives with ciprofloxacin (CPX) and formaldehyde. Their potent antibacterial effect on Gram-positive bacteria was accompanied by similarly strong activity against Gram-negative strains. The toxicity of the CPX-triazole hybrids for bacterial cells was even up to 18930 times higher than the toxicity for human cells. The results of enzymatic studies showed that the antibacterial activ...
Source: European Journal of Medicinal Chemistry - April 29, 2015 Category: Chemistry Authors: Plech T, Kaproń B, Paneth A, Kosikowska U, Malm A, Strzelczyk A, Stączek P, Świątek Ł, Rajtar B, Polz-Dacewicz M Tags: Eur J Med Chem Source Type: research
Topological pattern for the search of new active drugs against methicillin resistant Staphylococcus aureus.
Abstract
Molecular topology was used to develop a mathematical model capable of classifying compounds according to antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA). Topological indices were used as structural descriptors and their relation to antimicrobial activity was determined by using linear discriminant analysis. This topological model establishes new structure activity relationships which show that the presence of cyclopropyl, chlorine and ramification pairs at a distance of two bonds favor this activity, while the presence of tertiary amines decreases it. This model was appl...
Source: European Journal of Medicinal Chemistry - July 8, 2017 Category: Chemistry Authors: Bueso-Bordils JI, Perez-Gracia MT, Suay-Garcia B, Duart MJ, Martin Algarra RV, Lahuerta Zamora L, Anton-Fos GM, Aleman Lopez PA Tags: Eur J Med Chem Source Type: research
From quinoline to quinazoline-based S. aureus NorA efflux pump inhibitors by coupling focused scaffold hopping approach and pharmacophore search
ChemMedChem. 2021 May 25. doi: 10.1002/cmdc.202100282. Online ahead of print.ABSTRACTAntibiotic resistance breakers, such as efflux pump inhibitors (EPIs), represent a powerful alternative to the development of new antimicrobials. Recently, by using previously described EPIs, we developed pharmacophore models able to identify inhibitors of NorA, the most studied efflux pump of the Staphylococcus aureus. Herein, we reported a pharmacophore-based virtual screening of a library of new potential NorA EPIs generated by an in-silico scaffold hopping approach of the quinoline core. After chemical synthesis and biological evaluati...
Source: ChemMedChem - May 25, 2021 Category: Chemistry Authors: Nicholas Cedraro Rolando Cannalire Andrea Astolfi Gianmarco Mangiaterra Tommaso Felicetti Salvatore Vaiasicca Giada Cernicchi Serena Massari Giuseppe Manfroni Oriana Tabarrini Violetta Cecchetti Maria Letizia Barreca Francesca Biavasco Stefano Sabatini Source Type: research
Search for a Shared Genetic or Biochemical Basis for Biofilm Tolerance to Antibiotics across Bacterial Species
Antimicrob Agents Chemother. 2022 Mar 10:e0002122. doi: 10.1128/aac.00021-22. Online ahead of print.ABSTRACTIs there a universal genetically programmed defense providing tolerance to antibiotics when bacteria grow as biofilms? A comparison between biofilms of three different bacterial species by transcriptomic and metabolomic approaches uncovered no evidence of one. Single-species biofilms of three bacterial species (Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii) were grown in vitro for 3 days and then challenged with respective antibiotics (ciprofloxacin, daptomycin, and tigecycline) for an ad...
Source: Antimicrobial Agents and Chemotherapy - March 10, 2022 Category: Microbiology Authors: Philip S Stewart Kerry S Williamson Laura Boegli Timothy Hamerly Ben White Liam Scott Xiao Hu Brendan M Mumey Michael J Franklin Brian Bothner Francisco G Vital-Lopez Anders Wallqvist Garth A James Source Type: research
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis
CONCLUSIONS: We found that nebulised antibiotics, alone or with oral antibiotics, were better than no treatment for early infection with P aeruginosa. Eradication may be sustained in the short term. There is insufficient evidence to determine whether these antibiotic strategies decrease mortality or morbidity, improve quality of life, or are associated with adverse effects compared to placebo or standard treatment. Four trials comparing two active treatments have failed to show differences in rates of eradication of P aeruginosa. One large trial showed that intravenous ceftazidime with tobramycin is not superior to oral ci...
Source: Cochrane Database of Systematic Reviews - June 2, 2023 Category: General Medicine Authors: Simon C Langton Hewer Sherie Smith Nicola J Rowbotham Alexander Yule Alan R Smyth Source Type: research
A Year in Review: FDA 2015 New Drug Approvals
The approval of first-of-a-kind drugs rose last year to forty-one, resulting in the highest level of newly approved U.S. drugs in nineteen years. The total number of new drugs approved last year was even higher at sixty-nine. The rising figures reflect an industry-wide desire to research and develop drugs for rare and hard-to-treat diseases.
The newly approved drugs serve to advance medical care and the health of patients suffering from many ailments, including various forms of cancer, heart failure, and cystic fibrosis. Additionally, more than 40% of the new therapies were approved for treatment of rare or "orphan" dise...
Source: Policy and Medicine - January 13, 2016 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs
Screening approach for identifying candidate drugs and drug ‐drug interactions related to hip fracture risk in persons with Alzheimer disease
ConclusionsCase‐crossover analysis is a potential approach for identifying candidate drugs and drug‐drug interactions associated with adverse events as it implicitly controls for fixed confounders. The results are highly dependent on applied hazard and control periods, but the choice of periods can help in targeting the analyses to different phases of drug use.
Source: Pharmacoepidemiology and Drug Safety - May 1, 2017 Category: Drugs & Pharmacology Authors: Anna ‐Maija Tolppanen, Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Jussi Paananen, Jari Tiihonen, Sirpa Hartikainen Tags: ORIGINAL REPORT Source Type: research
An Unusual Hypoxia Patient
BY GORDON MURPHY, PA-C, MPHThe patient was blue, her primary care physician noted. Quite literally, in fact.The 38-year-old woman had sought care for a recurrent urinary tract infection, and that's when her primary care physician found her pulse oximetry to be 74%. He was concerned about hypoxia and asked us to evaluate her.The patient reported taking an SSRI for anxiety and having a hormone-eluting IUD. She had previously had a Roux-en-Y gastric bypass. She said she had a headache, but had been instructed not to take NSAIDs. She said she had just finished a course of Cipro for her UTI, but continued to be symptomatic w...
Source: The Case Files - February 20, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Genomic Characterization of Arcobacter butzleri Isolated From Shellfish: Novel Insight Into Antibiotic Resistance and Virulence Determinants
Conclusion
Genomic analyses herein performed allowed us to confirm the recently (Pérez-Cataluña et al., 2018a,b) suggested amendment of A. butzleri as Al. butzlerii, comb. nov.
Antimicrobial susceptibility tests defined Ab 55 and Ab 6V strains as resistant to vancomycin, tetracyclin, nalidixic acid (only Ab 55 whereas Ab 6V is intermediate resistant), erythromycin, and β-lactam antibiotics. Moreover, in our strains isolated from shellfish, we identified numerous virulence, antibiotic, and heavy metal resistance determinants, also additional to those previously found in the genome sequenced A. butzler...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research
