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Therapy: Corticosteroid Therapy
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Total 18765 results found since Jan 2013.
Identifying clusters of coexisting conditions and outcomes among adults admitted to hospital with community-acquired pneumonia: a multicentre cohort study
We described differences in medications, imaging and outcomes.RESULTS: Patients clustered into 7 subgroups. The low comorbidity subgroup (n = 3052, 27.5%) had no comorbidities. The DM-HF-Pulm subgroup had prevalent diabetes, heart failure and chronic lung disease (n = 1710, 15.4%). One disease category defined each remaining subgroup, as follows: pulmonary (n = 1621, 14.6%), diabetes (n = 1281, 11.6%), heart failure (n = 1370, 12.4%), dementia (n = 1038, 9.4%) and cancer (n = 1013, 9.1%). Corticosteroid use ranged from 11.5% to 64.9% in the dementia and pulmonary subgroups, respectively. Piperacillin-tazobactam use ranged ...
Source: cmaj - September 5, 2023 Category: General Medicine Authors: Sarah L Malecki Hae Young Jung Anne Loffler Mark A Green Samir Gupta Derek MacFadden Nick Daneman Ross Upshur Michael Fralick Lauren Lapointe-Shaw Terence Tang Adina Weinerman Janice L Kwan Jessica J Liu Fahad Razak Amol A Verma Source Type: research
Platelet-rich plasma versus corticosteroid: a randomized controlled trial on tennis elbow patients resistant to nonsurgical treatments
CONCLUSION: In conclusion, larger studies with parallel groups and more diverse CS doses and types with baseline matching are needed to confirm the short-term benefits of PRP. Investigating the effects of different CS doses using ultrasound techniques is recommended.PMID:37663722 | PMC:PMC10473312 | DOI:10.1097/MS9.0000000000001115
Source: Hand Surgery - September 4, 2023 Category: Surgery Authors: Shahram Sayadi Parmida Shahbazi Arvin Najafi Fatemeh Ochi Kyana Jafarabady Mohammad M Rezaei Salman Azarsina Source Type: research
Proof of concept of intracochlear drug administration by laser-assisted bioprinting in mice
Hear Res. 2023 Aug 29;438:108880. doi: 10.1016/j.heares.2023.108880. Online ahead of print.ABSTRACTTranstympanic administration is used clinically for the injection of gentamicin and/or corticosteroids. This atraumatic route is based on passive diffusion through the round window membrane (RWM). The main limitation of this method is related to the clearance through the Eustachian tube, making the concentration of the therapeutic agent at the intracochlear level uncertain and limited. Moreover, this technique remains unsuitable for molecules of high molecular weight or in the case of gene therapies. The purpose was to study ...
Source: Hearing Research - September 4, 2023 Category: Audiology Authors: Manon Jaffredo Oc éane Duchamp Nicolas Touya Yohan Bouleau Didier Dulon Raphael Devillard Damien Bonnard Source Type: research
Platelet-rich plasma versus corticosteroid: a randomized controlled trial on tennis elbow patients resistant to nonsurgical treatments
CONCLUSION: In conclusion, larger studies with parallel groups and more diverse CS doses and types with baseline matching are needed to confirm the short-term benefits of PRP. Investigating the effects of different CS doses using ultrasound techniques is recommended.PMID:37663722 | PMC:PMC10473312 | DOI:10.1097/MS9.0000000000001115
Source: Hand Surgery - September 4, 2023 Category: Surgery Authors: Shahram Sayadi Parmida Shahbazi Arvin Najafi Fatemeh Ochi Kyana Jafarabady Mohammad M Rezaei Salman Azarsina Source Type: research
Adherence to 5-aminosalicylic acid maintenance treatment in young people with ulcerative colitis: a retrospective cohort study in primary care
CONCLUSION: The first year of starting long-term therapies in adolescents and young adults diagnosed with UC is a critical window for active follow-up of maintenance treatment, particularly in those aged 18-24 years and those living in deprived postcodes.PMID:37666511 | DOI:10.3399/BJGP.2023.0006
Source: The British Journal of General Practice - September 4, 2023 Category: Primary Care Authors: Nishani Jayasooriya Richard C Pollok Jonathan Blackwell Alex Bottle Irene Petersen Hanna Creese Sonia Saxena POP-IBD study group Source Type: research
Proof of concept of intracochlear drug administration by laser-assisted bioprinting in mice
Hear Res. 2023 Aug 29;438:108880. doi: 10.1016/j.heares.2023.108880. Online ahead of print.ABSTRACTTranstympanic administration is used clinically for the injection of gentamicin and/or corticosteroids. This atraumatic route is based on passive diffusion through the round window membrane (RWM). The main limitation of this method is related to the clearance through the Eustachian tube, making the concentration of the therapeutic agent at the intracochlear level uncertain and limited. Moreover, this technique remains unsuitable for molecules of high molecular weight or in the case of gene therapies. The purpose was to study ...
Source: Hearing Research - September 4, 2023 Category: Audiology Authors: Manon Jaffredo Oc éane Duchamp Nicolas Touya Yohan Bouleau Didier Dulon Raphael Devillard Damien Bonnard Source Type: research
Adherence to 5-aminosalicylic acid maintenance treatment in young people with ulcerative colitis: a retrospective cohort study in primary care
CONCLUSION: The first year of starting long-term therapies in adolescents and young adults diagnosed with UC is a critical window for active follow-up of maintenance treatment, particularly in those aged 18-24 years and those living in deprived postcodes.PMID:37666511 | DOI:10.3399/BJGP.2023.0006
Source: The British Journal of General Practice - September 4, 2023 Category: Primary Care Authors: Nishani Jayasooriya Richard C Pollok Jonathan Blackwell Alex Bottle Irene Petersen Hanna Creese Sonia Saxena POP-IBD study group Source Type: research
The utility of H2 receptor antagonists in preventing infusion-related reactions to paclitaxel chemotherapy
CONCLUSIONS: The removal of H2RAs from premedication for paclitaxel did not result in an increased incidence of IRRs. The use of H2RAs in preventing IRRs to paclitaxel should be re-evaluated.PMID:37665180 | DOI:10.1002/cncr.35006
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Corey Tsang Jessica Robinson Paul F Wheatley-Price Stephanie Y Brule Sara M Moore Source Type: research
Proof of concept of intracochlear drug administration by laser-assisted bioprinting in mice
Hear Res. 2023 Aug 29;438:108880. doi: 10.1016/j.heares.2023.108880. Online ahead of print.ABSTRACTTranstympanic administration is used clinically for the injection of gentamicin and/or corticosteroids. This atraumatic route is based on passive diffusion through the round window membrane (RWM). The main limitation of this method is related to the clearance through the Eustachian tube, making the concentration of the therapeutic agent at the intracochlear level uncertain and limited. Moreover, this technique remains unsuitable for molecules of high molecular weight or in the case of gene therapies. The purpose was to study ...
Source: Hearing Research - September 4, 2023 Category: Audiology Authors: Manon Jaffredo Oc éane Duchamp Nicolas Touya Yohan Bouleau Didier Dulon Raphael Devillard Damien Bonnard Source Type: research
PEG hydrogel containing dexamethasone-conjugated hyaluronic acid reduces secondary injury and improves motor function in a rat moderate TBI model
In this study, we evaluated the effect of locally applied PEG-bis-AA/HA-DXM hydrogel on secondary injury and motor function recovery after moderate controlled cortical impact (CCI) TBI. Hydrogel treatment significantly improved motor function evaluated by beam walk and rotarod tests compared to untreated rats over 7 days post-injury (DPI). We also observed that the hydrogel treatment reduced lesion volume, inflammatory response, astrogliosis, apoptosis, and increased neuronal survival compared to untreated rats at 7 DPI. These results suggest that PEG-bis-AA/HA-DXM hydrogels can mitigate secondary injury and promote motor ...
Source: Experimental Neurology - September 4, 2023 Category: Neurology Authors: Claire Jones Bradley Elliott Zhen Liao Zack Johnson Fuying Ma Zachary S Bailey Janice Gilsdorf Anke Scultetus Deborah Shear Ken Webb Jeoung Soo Lee Source Type: research
Adherence to 5-aminosalicylic acid maintenance treatment in young people with ulcerative colitis: a retrospective cohort study in primary care
CONCLUSION: The first year of starting long-term therapies in adolescents and young adults diagnosed with UC is a critical window for active follow-up of maintenance treatment, particularly in those aged 18-24 years and those living in deprived postcodes.PMID:37666511 | DOI:10.3399/BJGP.2023.0006
Source: The British Journal of General Practice - September 4, 2023 Category: Primary Care Authors: Nishani Jayasooriya Richard C Pollok Jonathan Blackwell Alex Bottle Irene Petersen Hanna Creese Sonia Saxena POP-IBD study group Source Type: research
PEG hydrogel containing dexamethasone-conjugated hyaluronic acid reduces secondary injury and improves motor function in a rat moderate TBI model
In this study, we evaluated the effect of locally applied PEG-bis-AA/HA-DXM hydrogel on secondary injury and motor function recovery after moderate controlled cortical impact (CCI) TBI. Hydrogel treatment significantly improved motor function evaluated by beam walk and rotarod tests compared to untreated rats over 7 days post-injury (DPI). We also observed that the hydrogel treatment reduced lesion volume, inflammatory response, astrogliosis, apoptosis, and increased neuronal survival compared to untreated rats at 7 DPI. These results suggest that PEG-bis-AA/HA-DXM hydrogels can mitigate secondary injury and promote motor ...
Source: Experimental Neurology - September 4, 2023 Category: Neurology Authors: Claire Jones Bradley Elliott Zhen Liao Zack Johnson Fuying Ma Zachary S Bailey Janice Gilsdorf Anke Scultetus Deborah Shear Ken Webb Jeoung Soo Lee Source Type: research
