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Therapy: Statin Therapy
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Total 11974 results found since Jan 2013.
Microextraction based on liquid-solid phase transition of benzoic acid: Extraction of statins from human urine followed by chromatographic analysis
Talanta. 2023 Aug 18;266(Pt 2):125088. doi: 10.1016/j.talanta.2023.125088. Online ahead of print.ABSTRACTHerein, a microextraction method was reported based on the liquid-solid phase transition of benzoic acid to quantify two statins, namely lovastatin and simvastatin in authentic human urine. The principle of the method is based on the phase transition of benzoic acid by altering the pH of the sample solution enabling efficient dispersion and phase separation in one step. Due to the moderate melting point of benzoic acid, its solidification is performed at ambient temperature without the need for sample cooling. Various e...
Source: Talanta - August 25, 2023 Category: Chemistry Authors: Natalia Manousi Paraskevas D Tzanavaras Constantinos K Zacharis Source Type: research
Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
We describe comorbidities in 3997 patients from Malawi, South Africa, and Zimbabwe. These patient cohorts were included in pharmacogenomic studies of anticoagulation, dyslipidemia, hypertension, HIV and breast cancer. The 20 topmost prescribed drugs in this population were identified. Using the literature, a list of pharmacogenes vital in the response to the top 20 drugs was constructed leading to drug-gene pairs potentially informative in translation of pharmacogenomics. The most reported morbidity was hypertension (58.4%), making antihypertensives the most prescribed drugs, particularly amlodipine. Dyslipidemia occurred ...
Source: Topics in HIV Medicine - August 25, 2023 Category: Infectious Diseases Authors: Nyarai Desiree Soko Sarudzai Muyambo Michelle T L Dandara Elizabeth Kampira Dirk Blom Erika S W Jones Brian Rayner Delva Shamley Phumla Sinxadi Collet Dandara Source Type: research
Statins and immune-mediated necrotizing myopathy: Variability in the risk
CONCLUSION: Atorvastatin presents the highest risk of IMNM. Our data suggest that the occurrence of IMNM is a class effect.PMID:37625939 | DOI:10.1016/j.therap.2023.07.005
Source: Therapie - August 25, 2023 Category: Psychiatry & Psychology Authors: Thierry Trenque Jed Hadjoudj Agathe Trenque Federica Tralongo Salom é Martin Brahim Azzouz Source Type: research
Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
We describe comorbidities in 3997 patients from Malawi, South Africa, and Zimbabwe. These patient cohorts were included in pharmacogenomic studies of anticoagulation, dyslipidemia, hypertension, HIV and breast cancer. The 20 topmost prescribed drugs in this population were identified. Using the literature, a list of pharmacogenes vital in the response to the top 20 drugs was constructed leading to drug-gene pairs potentially informative in translation of pharmacogenomics. The most reported morbidity was hypertension (58.4%), making antihypertensives the most prescribed drugs, particularly amlodipine. Dyslipidemia occurred ...
Source: Topics in HIV Medicine - August 25, 2023 Category: Infectious Diseases Authors: Nyarai Desiree Soko Sarudzai Muyambo Michelle T L Dandara Elizabeth Kampira Dirk Blom Erika S W Jones Brian Rayner Delva Shamley Phumla Sinxadi Collet Dandara Source Type: research
Using stable carbon isotope ratio analysis to detect adulteration in red yeast rice dietary supplements
Talanta. 2023 Aug 23;266(Pt 2):125076. doi: 10.1016/j.talanta.2023.125076. Online ahead of print.ABSTRACTRed yeast rice (RYR) is marketed as a dietary supplement because it contains natural 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins), including monacolin K. However, there is concern that some RYR supplements may be adulterated with the pharmaceutical drug lovastatin to enhance health claims. We have developed an optimized method to isolate monacolin K/lovastatin from complex RYR dietary supplement matrices to then test for adulteration in RYR supplements using stable carbon isotope (δ13C) analysis...
Source: Talanta - August 25, 2023 Category: Chemistry Authors: Kristen M Hannon Joshua D Sabala Madhavi Mantha Lisa M Lorenz John P Roetting Ii Matteo Perini Silvia Pianezze Kevin M Kubachka Source Type: research
Microextraction based on liquid-solid phase transition of benzoic acid: Extraction of statins from human urine followed by chromatographic analysis
Talanta. 2023 Aug 18;266(Pt 2):125088. doi: 10.1016/j.talanta.2023.125088. Online ahead of print.ABSTRACTHerein, a microextraction method was reported based on the liquid-solid phase transition of benzoic acid to quantify two statins, namely lovastatin and simvastatin in authentic human urine. The principle of the method is based on the phase transition of benzoic acid by altering the pH of the sample solution enabling efficient dispersion and phase separation in one step. Due to the moderate melting point of benzoic acid, its solidification is performed at ambient temperature without the need for sample cooling. Various e...
Source: Talanta - August 25, 2023 Category: Chemistry Authors: Natalia Manousi Paraskevas D Tzanavaras Constantinos K Zacharis Source Type: research
Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
We describe comorbidities in 3997 patients from Malawi, South Africa, and Zimbabwe. These patient cohorts were included in pharmacogenomic studies of anticoagulation, dyslipidemia, hypertension, HIV and breast cancer. The 20 topmost prescribed drugs in this population were identified. Using the literature, a list of pharmacogenes vital in the response to the top 20 drugs was constructed leading to drug-gene pairs potentially informative in translation of pharmacogenomics. The most reported morbidity was hypertension (58.4%), making antihypertensives the most prescribed drugs, particularly amlodipine. Dyslipidemia occurred ...
Source: Topics in HIV Medicine - August 25, 2023 Category: Infectious Diseases Authors: Nyarai Desiree Soko Sarudzai Muyambo Michelle T L Dandara Elizabeth Kampira Dirk Blom Erika S W Jones Brian Rayner Delva Shamley Phumla Sinxadi Collet Dandara Source Type: research
Acute hepatitis of unknown etiology in an adult female: A case report
CONCLUSION: Idiopathic hepatitis makes treatment challenging. It can leave patients feeling confused and unfulfilled. Thus, educating the patient thoroughly for shared decision-making and management becomes essential.PMID:37621598 | PMC:PMC10445075 | DOI:10.12998/wjcc.v11.i22.5288
Source: Herpes - August 25, 2023 Category: Infectious Diseases Authors: Lucinda Dass Alexandra Marie Malabanan Pacia Mahgol Hamidi Source Type: research
Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
We describe comorbidities in 3997 patients from Malawi, South Africa, and Zimbabwe. These patient cohorts were included in pharmacogenomic studies of anticoagulation, dyslipidemia, hypertension, HIV and breast cancer. The 20 topmost prescribed drugs in this population were identified. Using the literature, a list of pharmacogenes vital in the response to the top 20 drugs was constructed leading to drug-gene pairs potentially informative in translation of pharmacogenomics. The most reported morbidity was hypertension (58.4%), making antihypertensives the most prescribed drugs, particularly amlodipine. Dyslipidemia occurred ...
Source: Topics in HIV Medicine - August 25, 2023 Category: Infectious Diseases Authors: Nyarai Desiree Soko Sarudzai Muyambo Michelle T L Dandara Elizabeth Kampira Dirk Blom Erika S W Jones Brian Rayner Delva Shamley Phumla Sinxadi Collet Dandara Source Type: research
Using stable carbon isotope ratio analysis to detect adulteration in red yeast rice dietary supplements
Talanta. 2023 Aug 23;266(Pt 2):125076. doi: 10.1016/j.talanta.2023.125076. Online ahead of print.ABSTRACTRed yeast rice (RYR) is marketed as a dietary supplement because it contains natural 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins), including monacolin K. However, there is concern that some RYR supplements may be adulterated with the pharmaceutical drug lovastatin to enhance health claims. We have developed an optimized method to isolate monacolin K/lovastatin from complex RYR dietary supplement matrices to then test for adulteration in RYR supplements using stable carbon isotope (δ13C) analysis...
Source: Talanta - August 25, 2023 Category: Chemistry Authors: Kristen M Hannon Joshua D Sabala Madhavi Mantha Lisa M Lorenz John P Roetting Ii Matteo Perini Silvia Pianezze Kevin M Kubachka Source Type: research
Statins and immune-mediated necrotizing myopathy: Variability in the risk
CONCLUSION: Atorvastatin presents the highest risk of IMNM. Our data suggest that the occurrence of IMNM is a class effect.PMID:37625939 | DOI:10.1016/j.therap.2023.07.005
Source: Therapie - August 25, 2023 Category: Psychiatry & Psychology Authors: Thierry Trenque Jed Hadjoudj Agathe Trenque Federica Tralongo Salom é Martin Brahim Azzouz Source Type: research
