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Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
We describe comorbidities in 3997 patients from Malawi, South Africa, and Zimbabwe. These patient cohorts were included in pharmacogenomic studies of anticoagulation, dyslipidemia, hypertension, HIV and breast cancer. The 20 topmost prescribed drugs in this population were identified. Using the literature, a list of pharmacogenes vital in the response to the top 20 drugs was constructed leading to drug-gene pairs potentially informative in translation of pharmacogenomics. The most reported morbidity was hypertension (58.4%), making antihypertensives the most prescribed drugs, particularly amlodipine. Dyslipidemia occurred ...
Source: Topics in HIV Medicine - August 25, 2023 Category: Infectious Diseases Authors: Nyarai Desiree Soko Sarudzai Muyambo Michelle T L Dandara Elizabeth Kampira Dirk Blom Erika S W Jones Brian Rayner Delva Shamley Phumla Sinxadi Collet Dandara Source Type: research
The potential impact of computed tomography coronary calcium score screening on patients with dyslipidemia
CONCLUSION: CAC scoring is associated with reduced risk of myocardial infarction and death in asymptomatic dyslipidemia patients and should be considered as a screening tool in these patients. The presumed mechanism for improved outcomes is that early identification of CAD results in earlier or more intensive treatment, reducing future cardiac event risk.PMID:37614860 | PMC:PMC10444005 | DOI:10.1080/08998280.2023.2239083
Source: Baylor University Medical Center Proceedings - August 24, 2023 Category: Universities & Medical Training Authors: Brittany Miles Bunnarin Theng Bright O Etumuse Atefeh Zeinoddini Arsalan Saleem Source Type: research
Statin prescribing patterns in patient-centered medical home patients with NAFLD
CONCLUSIONS: This study showed no association between NAFLD and statin prescribing, and the findings highlight opportunities to improve primary prevention of cardiovascular disease in these at-risk patients.PMID:37616147 | DOI:10.37765/ajmc.2023.89406
Source: The American Journal of Managed Care - August 24, 2023 Category: Health Management Authors: Allison L Cipriani Chelsey A Petz Ellen M Nielsen Justin Marsden Andrew D Schreiner Source Type: research
The potential impact of computed tomography coronary calcium score screening on patients with dyslipidemia
CONCLUSION: CAC scoring is associated with reduced risk of myocardial infarction and death in asymptomatic dyslipidemia patients and should be considered as a screening tool in these patients. The presumed mechanism for improved outcomes is that early identification of CAD results in earlier or more intensive treatment, reducing future cardiac event risk.PMID:37614860 | PMC:PMC10444005 | DOI:10.1080/08998280.2023.2239083
Source: Baylor University Medical Center Proceedings - August 24, 2023 Category: Universities & Medical Training Authors: Brittany Miles Bunnarin Theng Bright O Etumuse Atefeh Zeinoddini Arsalan Saleem Source Type: research
Incorporation and performance verification of hepatic portal blood flow shunting in minimal and full PBPK models of liver cirrhosis
The objectives of this work were to implement a Physiologically Based Pharmacokinetic (PBPK) framework describing shunted blood flows in virtual patients with differing degrees of liver cirrhosis; and to assess the minimal and full PBPK models performance using drugs with intermediate to high hepatic extraction. Single dose concentration-time profiles and PK parameters for oral Ibrutinib, midazolam, propranolol and buspirone were simulated in Healthy-Volunteer (HV) and subjects with cirrhosis (Child-Pugh severity score A, B or C). Model performance was verified by comparing predicted to observed fold-changes in PK paramete...
Source: Clinical Pharmacology and Therapeutics - August 24, 2023 Category: Drugs & Pharmacology Authors: Ben G Small Oliver Hatley Masoud Jamei Iain Gardner Trevor N Johnson Source Type: research
Statin prescribing patterns in patient-centered medical home patients with NAFLD
CONCLUSIONS: This study showed no association between NAFLD and statin prescribing, and the findings highlight opportunities to improve primary prevention of cardiovascular disease in these at-risk patients.PMID:37616147 | DOI:10.37765/ajmc.2023.89406
Source: The American Journal of Managed Care - August 24, 2023 Category: Health Management Authors: Allison L Cipriani Chelsey A Petz Ellen M Nielsen Justin Marsden Andrew D Schreiner Source Type: research
