• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Emergence of Marburg virus: a global perspective on fatal outbreaks and clinical challenges
The Marburg virus (MV), identified in 1967, has caused deadly outbreaks worldwide, the mortality rate of Marburg virus disease (MVD) varies depending on the outbreak and virus strain, but the average case fatality rate is around 50%. However, case fatality rates have varied from 24 to 88% in past outbreaks depending on virus strain and case management. Designated a priority pathogen by the National Institute of Allergy and Infectious Diseases (NIAID), MV induces hemorrhagic fever, organ failure, and coagulation issues in both humans and non-human primates. This review presents an extensive exploration of MVD outbreak evolu...
Source: Frontiers in Microbiology - September 13, 2023 Category: Microbiology Source Type: research

Human intestinal organoids as models to study enteric bacteria and viruses
Curr Opin Microbiol. 2023 Aug 1;75:102362. doi: 10.1016/j.mib.2023.102362. Online ahead of print.ABSTRACTLaboratory studies of host-microbe interactions have historically been carried out using transformed cell lines and animal models. Although much has been learned from these models, recent advances in the development of multicellular, physiologically active, human intestinal organoid (HIO) cultures are allowing unprecedented discoveries of host-microbe interactions. Here, we review recent literature using HIOs as models to investigate the pathogenesis of clinically important enteric bacteria and viruses and study commens...
Source: Current Opinion in Microbiology - August 3, 2023 Category: Microbiology Authors: Grace Adeniyi-Ipadeola Hephzibah Nwanosike Sasirekha Ramani Source Type: research

Repurposing Polyether Ionophores as a New-Class of Anti-SARS-Cov-2 Agents as Adjunct Therapy
Curr Microbiol. 2023 Jul 6;80(8):273. doi: 10.1007/s00284-023-03366-1.ABSTRACTThe emergence of SARS-CoV-2 and its variants have posed a significant threat to humankind in tackling the viral spread. Furthermore, currently repurposed drugs and frontline antiviral agents have failed to cure severe ongoing infections effectively. This insufficiency has fuelled research for potent and safe therapeutic agents to treat COVID-19. Nonetheless, various vaccine candidates have displayed a differential efficacy and need for repetitive dosing. The FDA-approved polyether ionophore veterinary antibiotic for treating coccidiosis has been ...
Source: Current Microbiology - July 6, 2023 Category: Microbiology Authors: Keerthana Gurukkalot Vinoth Rajendran Source Type: research

Insights into the challenging multi-country outbreak of Mpox: a comprehensive review
J Med Microbiol. 2023 Jun;72(6). doi: 10.1099/jmm.0.001725.ABSTRACTHuman monkeypox virus (hMpoxV) is of zoonotic origin and is closely related to the once-dreaded smallpox virus. It is largely endemic to the African continent but has moved out of the endemic regions as sporadic clusters in the past 20 years, raising concerns worldwide. Human Mpox is characterized by a mild to severe, self-limiting infection, with mortality ranging from less than 1% to up to 10% during different outbreaks caused by different clades of MpoxV. Bushmeat hunting is one of the primary reasons for its transmission from animals to humans. Various ...
Source: Journal of Medical Microbiology - June 28, 2023 Category: Microbiology Authors: Shreyas Bhat Sumana Saha Tanisha Garg Himanshu Sehrawat Balu Ananda Chopade Vandana Gupta Source Type: research

Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations
Clin Microbiol Rev. 2023 Jun 12:e0016422. doi: 10.1128/cmr.00164-22. Online ahead of print.ABSTRACTBordetella pertussis and Bordetella bronchiseptica belong to the genus Bordetella, which comprises 14 other species. B. pertussis is responsible for whooping cough in humans, a severe infection in children and less severe or chronic in adults. These infections are restricted to humans and currently increasing worldwide. B. bronchiseptica is involved in diverse respiratory infections in a wide range of mammals. For instance, the canine infectious respiratory disease complex (CIRDC), characterized by a chronic cough in dogs. At...
Source: Clinical Microbiology Reviews - June 12, 2023 Category: Microbiology Authors: Beatriz Miguelena Chamorro Karelle De Luca Gokul Swaminathan St éphanie Longet Egbert Mundt St éphane Paul Source Type: research

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15