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Specialty: Microbiology
Vaccination: Vaccines
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Total 1746 results found since Jan 2013.
Insights into enterovirus a-71 antiviral development: from natural sources to synthetic nanoparticles
Arch Microbiol. 2023 Sep 21;205(10):334. doi: 10.1007/s00203-023-03660-3.ABSTRACTEnteroviruses are pathogens responsible for several diseases, being enterovirus A71 (EVA71) the second leading cause of hand, foot, and mouth disease (HFMD), especially in Asia-Pacific countries. HFMD is mostly common in infants and children, with mild symptoms. However, the disease can result in severe nervous system disorders in children as well as in immunosuppressed adults. The virus is highly contagious, and its transmission occurs via fecal-oral, oropharyngeal secretions, and fomites. The EVA71 burdens the healthy systems and economies a...
Source: Archives of Microbiology - September 21, 2023 Category: Microbiology Authors: Shiraz Feferbaum-Leite Igor Andrade Santos Vict ória Riquena Grosche Gislaine Celestino Dutra da Silva Ana Carolina Gomes Jardim Source Type: research
Identification of a novel transcriptional regulator, CorR, for copper stress response in < em > Edwardsiella piscicida < /em >
Appl Environ Microbiol. 2023 Sep 21:e0089923. doi: 10.1128/aem.00899-23. Online ahead of print.ABSTRACTCopper plays a vital role in the host-pathogen interface, potentially making components of the bacterial copper response suitable targets for the development of innovative antimicrobial strategies. The anti-copper arsenal of intracellular pathogens has expanded as an adaptation to survive copper toxicity in order to escape intracellular killing by the host immune system. Herein, we employed transposon insertion sequencing to investigate the genetic mechanisms underlying the survival of Edwardsiella piscicida under copper ...
Source: Applied and Environmental Microbiology - September 21, 2023 Category: Microbiology Authors: Feng Xia Pengfei Xu Boya Zhang Yibei Zhang Xiaohong Liu Yue Ma Yuanxing Zhang Qiyao Wang Shuai Shao Source Type: research
I κBζ is an essential mediator of immunity to oropharyngeal candidiasis
Cell Host Microbe. 2023 Sep 11:S1931-3128(23)00341-4. doi: 10.1016/j.chom.2023.08.016. Online ahead of print.ABSTRACTFungal infections are a global threat; yet, there are no licensed vaccines to any fungal pathogens. Th17 cells mediate immunity to Candida albicans, particularly oropharyngeal candidiasis (OPC), but essential downstream mechanisms remain unclear. In the murine model of OPC, IκBζ (Nfkbiz, a non-canonical NF-κB transcription factor) was upregulated in an interleukin (IL)-17-dependent manner and was essential to prevent candidiasis. Deletion of Nfkbiz rendered mice highly susceptible to OPC. IκBζ was dispe...
Source: Cell Host and Microbe - September 19, 2023 Category: Microbiology Authors: Tiffany C Taylor Bianca M Coleman Samyuktha P Arunkumar Ipsita Dey John T Dillon Nicole O Ponde Amanda C Poholek Daniella M Schwartz Mandy J McGeachy Heather R Conti Sarah L Gaffen Source Type: research
Emergence of Marburg virus: a global perspective on fatal outbreaks and clinical challenges
The Marburg virus (MV), identified in 1967, has caused deadly outbreaks worldwide, the mortality rate of Marburg virus disease (MVD) varies depending on the outbreak and virus strain, but the average case fatality rate is around 50%. However, case fatality rates have varied from 24 to 88% in past outbreaks depending on virus strain and case management. Designated a priority pathogen by the National Institute of Allergy and Infectious Diseases (NIAID), MV induces hemorrhagic fever, organ failure, and coagulation issues in both humans and non-human primates. This review presents an extensive exploration of MVD outbreak evolu...
Source: Frontiers in Microbiology - September 13, 2023 Category: Microbiology Source Type: research
Emerging threat of antimicrobial resistance in Neisseria gonorrhoeae: pathogenesis, treatment challenges, and potential for vaccine development
Arch Microbiol. 2023 Sep 9;205(10):330. doi: 10.1007/s00203-023-03663-0.ABSTRACTThe continuous rise of antimicrobial resistance (AMR) is a serious concern as it endangers the effectiveness of healthcare interventions that rely on antibiotics in the long run. The increasing resistance of Neisseria gonorrhoeae, the bacteria responsible for causing gonorrhea, to commonly used antimicrobial drugs, is a major concern. This has now become a critical global health crisis. In the coming years, there is a risk of a hidden epidemic caused by the emergence of gonococcal AMR. This will worsen the global situation. Infections caused by...
Source: Archives of Microbiology - September 9, 2023 Category: Microbiology Authors: Umairah Natasya Mohd Omeershffudin Suresh Kumar Source Type: research
Effectiveness of COVID-19 vaccination against multisystem inflammatory syndrome in children: A systematic review and meta-analysis
J Microbiol Immunol Infect. 2023 Aug 19:S1684-1182(23)00154-8. doi: 10.1016/j.jmii.2023.08.002. Online ahead of print.NO ABSTRACTPMID:37673732 | DOI:10.1016/j.jmii.2023.08.002
Source: Journal of Microbiology, Immunology, and Infection - September 6, 2023 Category: Microbiology Authors: Ting-Hui Liu Po-Yu Huang Jheng-Yan Wu Kun-Ming Chung Chih-Cheng Lai Hung-Jen Tang Source Type: research
Perkinsus marinus in bioreactor: Growth and a cost-reduced growth medium
This study opens the door to furthering P. marinus as a valid heterologous expression system by showing the ability to grow in bioreactors.PMID:37669897 | DOI:10.1093/jimb/kuad023
Source: Journal of Industrial Microbiology and Biotechnology - September 5, 2023 Category: Microbiology Authors: Caitlin Murphy Jos é A Fernández Robledo G Peter Van Walsum Source Type: research
A highly-safe live auxotrophic vaccine protecting against disease caused by non-typhoidal Salmonella Typhimurium in mice
CONCLUSION: This study yielded a very safe S. Typhimurium vaccine candidate that could be further refined for mucosal application against disease in humans.PMID:37610206 | DOI:10.1016/j.jmii.2022.10.002
Source: Journal of Microbiology, Immunology, and Infection - August 23, 2023 Category: Microbiology Authors: Patricia Garc ía Miriam Moscoso V íctor Fuentes-Valverde M Rosario Rodicio Silvia Herrera-Le ón Germ án Bou Source Type: research
