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Specialty: Chemistry
Therapy: Antibiotic Therapy
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Total 60 results found since Jan 2013.
Design, synthesis and biological evaluation of novel 3-hydroxypyridin-4(1H)-ones based hybrids as Pseudomonas aeruginosa biofilm inhibitors
In conclusion, 3-hydroxypyridin-4(1H)-one hybrids, such as 12h, represent a promising class of antibacterial agents against P. aeruginosa.PMID:37506546 | DOI:10.1016/j.ejmech.2023.115665
Source: European Journal of Medicinal Chemistry - July 28, 2023 Category: Chemistry Authors: Jun Liu Ying Meng Ming-Han Yang Xiao-Yi Zhang Jian-Fu Zhao Ping-Hua Sun Wei-Min Chen Source Type: research
Immunologic biomarkers for bacterial meningitis
This study provides an overview of different immunologic biomarkers as diagnostic markers for the identification of bacterial meningitis and their efficiencies in the differentiating of bacterial from viral meningitis.PMID:37419301 | DOI:10.1016/j.cca.2023.117470
Source: International Journal of Clinical Chemistry - July 7, 2023 Category: Chemistry Authors: Mina Yekani Mohammad Yousef Memar Source Type: research
Cellular membrane-targeting ruthenium complexes as efficient photosensitizers for broad-spectrum antibacterial activity
Dalton Trans., 2023, Advance Article DOI: 10.1039/D3DT01001E, PaperYi Wang, Ya-Tao Hu, Hai-Lin Zhang, Yu-Yu Chen, Hong-Dong Shi, Jin-Gang Liu, Qian-Ling Zhang A ruthenium complex [Ru(phen)2(phen-5-amine)-C14] (Ru-C14) with broad-spectrum antibacterial activity was synthesized.Ru-C14 can target and image the cell membrane and can be used as a photosensitizer for photodynamic antimicrobial therapy under 465 nm light irradiation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - May 26, 2023 Category: Chemistry Authors: Yi Wang Source Type: research
Small molecular fluorescent probes : application progress of specific bacteria detection and antibacterial phototherapy
Chem Asian J. 2023 Apr 23:e202300178. doi: 10.1002/asia.202300178. Online ahead of print.ABSTRACTBacterial infection is one of the leading causes of death worldwide and is easy to cause large-scale diseases. It is an urgent need to develop effective methods for the specific detection and treatment of bacterial infections. Recently, small molecular fluorescent probes, bridging the capability of imaging detection and sterilization, have attracted increasing attention. Fluorescence imaging assays have the benefit of being simple, specific, and fast, which is very advantageous in both in vitro and in vivo bacterial detection. ...
Source: Chemistry, an Asian Journal - April 23, 2023 Category: Chemistry Authors: Yangzhi Kong Qunying Jiang Fan Zhang Yang Yang Source Type: research
Hybrids diazine: Recent Advancements in Modern Antimicrobial Therapy
Curr Med Chem. 2023 Apr 18. doi: 10.2174/0929867330666230418104409. Online ahead of print.ABSTRACTNowadays, antimicrobial therapies have become a very challenging issue because of a large diversity of reasons such as antimicrobial resistance, over consumption and misuse of antimicrobial agents, etc. A modern, actual and very useful approach in antimicrobial therapy is represented by the use of hybrid drugs, especially combined five and six-membered ring azaheterocycles. In this review, we present an overview of the recent advanced data from the last five years in the field of hybrid diazine compounds with antimicrobial act...
Source: Current Medicinal Chemistry - April 18, 2023 Category: Chemistry Authors: Mangalagiu Violeta Danac Ramona Diaconu Dumitrela Zbancioc Gheorghita Mangalagiu Ionel I Source Type: research
Plant-based Natural Products as inhibitors for Efflux Pumps to Reverse Multidrug Resistance in Staphylococcus aureus: A Mini Review
CONCLUSION: Many synthetic efflux pump inhibitors to treat wound infections are still under clinical trials. In this connection, several investigations have been carried out on plant-based natural products as multidrug resistance-modifying agents as they are believed to be safe, inexpensive and suitable for chronic wound infections.PMID:37038687 | DOI:10.2174/1389557523666230406092128
Source: Mini Reviews in Medicinal Chemistry - April 11, 2023 Category: Chemistry Authors: Shalini Ramalingam Moola Joghee Nanjan Chandrasekar Ganesh Gnk Moola Joghee Nanjan Source Type: research
Specific discrimination and efficient elimination of gram-positive bacteria by an aggregation-induced emission-active ruthenium (II) photosensitizer
Eur J Med Chem. 2023 Mar 2;251:115249. doi: 10.1016/j.ejmech.2023.115249. Online ahead of print.ABSTRACTThe infections caused by Gram-positive bacteria (G+) have seriously endangered public heath due to their high morbidity and mortality. Therefore, it is urgent to develop a multifunctional system for selective recognition, imaging and efficient eradication of G+. Aggregation-induced emission materials have shown great promise for microbial detection and antimicrobial therapy. In this paper, a multifunctional ruthenium (II) polypyridine complex Ru2 with aggregation-induced emission (AIE) characteristic, was developed and u...
Source: European Journal of Medicinal Chemistry - March 9, 2023 Category: Chemistry Authors: Mengling Liu Wenzhu Song Peipei Deng Shuli Nong Xianpeng Zhang Yue Yu Guanying Li Li Xu Source Type: research
Directly single-cell antimicrobial susceptibility testing of Escherichia coli in urine using a ready-to-use 3D microwell array chip
Lab Chip, 2023, Accepted Manuscript DOI: 10.1039/D2LC01095J, PaperWenshuai Wu, Gaozhe Cai, Yang Liu, Yuanjie Suo, Boran Zhang, Wei Jin, Yinghua Yu, Ying Mu The empirical antibiotic therapies are prescribed for treating uncomplicated urinary tract infections (UTIs) due to the long turnaround time of conventional antimicrobial susceptibility testing (AST), leading to the prevalence of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - February 14, 2023 Category: Chemistry Authors: Wenshuai Wu Source Type: research
