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Specialty: Chemistry
Therapy: Palliative
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Total 29 results found since Jan 2013.
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties
Eur J Med Chem. 2023 Sep 12;261:115803. doi: 10.1016/j.ejmech.2023.115803. Online ahead of print.ABSTRACTNeurodegenerative processes characterizing Alzheimer's disease (AD) are strictly related to the impairment of cholinergic and glutamatergic neurotransmitter systems which provoke synaptic loss. These experimental evidences still represent the foundation of the actual standard-of-care treatment for AD, albeit palliative, consisting on the coadministration of an acetylcholinesterase inhibitor and the NMDAR antagonist memantine. In looking for more effective treatments, we previously developed a series of galantamine-meman...
Source: European Journal of Medicinal Chemistry - September 21, 2023 Category: Chemistry Authors: Filippo Basagni Jose A Ortega Sine M Bertozzi Andrea Armirotti Maria Summa Rosalia Bertorelli Manuela Bartolini Ian R Mellor Martina Bedeschi Giovanni Bottegoni Vittorio Lembo Anna Minarini Andrea Cavalli Michela Rosini Source Type: research
SNHG11 ：A New Budding Star in Tumors and Inflammatory Diseases
CONCLUSION: LncRNA SNHG11 can serve as an early diagnostic biomarker, therapeutic target, and prognostic indicator in various diseases, particularly tumors. SNHG11 plays a crucial role in the occurrence and development of tumors and inflammatory diseases through various mechanisms, which has significant implications for clinical diagnosis and treatment.PMID:37165588 | DOI:10.2174/1389557523666230509122402
Source: Mini Reviews in Medicinal Chemistry - May 11, 2023 Category: Chemistry Authors: Yinxin Wu Source Type: research
Molecules, Vol. 28, Pages 1394: Bio-Prospecting of Crude Leaf Extracts from Thirteen Plants of Brazilian Cerrado Biome on Human Glioma Cell Lines
Conclusion: These findings highlight M. chamissois chloroform partition as a promising component and may guide the search for the development of additional new anticancer therapies.
Source: Molecules - February 1, 2023 Category: Chemistry Authors: Silva Rosa Gomes Vital Alves Evangelista Longato Carloni Oliveira Pinto Rom ão Rezende Ara újo Oliveira Souza Oliveira Ribeiro Reis Tags: Article Source Type: research
Identification of novel Zika virus inhibitors: a screening using thiosemicarbazones and thiazoles templates
CONCLUSION: These derivatives are promising candidates for further assays. In addition, the current approach brings a new privileged scaffolding, which may drive future drug discovery for ZIKV.PMID:36567284 | DOI:10.2174/1568026623666221222124433
Source: Current Topics in Medicinal Chemistry - December 25, 2022 Category: Chemistry Authors: Paulo Andr é Teixeira de Moraes Gomes Luiz Alberto Barros Freitas Luciana Rabelo Pessoa Siqueira Juliana Maria da Concei ção Ignes Regina Dos Santos Aline Ferreira Pinto Vanessa Gouveia de Melo Silva Janine Siqueira Nunes Marcos Ver íssimo de Oliveira Source Type: research
Natural Products with BACE1 and GSK3 β Inhibitory Activity
Mini Rev Med Chem. 2022 Nov 18. doi: 10.2174/1389557523666221118113923. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative, progressive, and fatal disorder characterized by marked atrophy of the cerebral cortex and loss of basal forebrain cholinergic neurons. The main pathological features of AD are related to neuronal degeneration and include extracellular deposition of amyloid beta plaques (Aβ plaques), intracellular formation of neurofibrillary tangles (NFTs), and neuroinflammation. So far, drugs used to treat AD have symptomatic and palliative pharmacological effects, disappearing with conti...
Source: Mini Reviews in Medicinal Chemistry - November 22, 2022 Category: Chemistry Authors: Paulo C ézar Prado Jos élia Alencar Lima Lidilhone Hamerski Magdalena Nascimento Renn ó Source Type: research
The Functions of EphA1 receptor tyrosine kinase in Several Tumors
CONCLUSION: RTK EphA1 can be used as a biomarker for tumor diagnosis (especially a prognostic marker), an indispensable therapeutic target for new anti-tumor therapies, and a novel anti-tumor drug.PMID:35996244 | DOI:10.2174/0929867329666220820125638
Source: Current Medicinal Chemistry - August 23, 2022 Category: Chemistry Authors: Yinxin Wu Zhuoying Du Jie Mou Xinyan Qiu Jinlan Chen Sanjin Cai Dongming Ren Fangxiang Xiao Gang Zhou Chengfu Yuan Source Type: research
A large-area organic transistor with 3D-printed sensing gate for noninvasive single-molecule detection of pancreatic mucinous cyst markers
This study provides a promising application of the 3D SiMoT platform, potentially facilitating the timely, noninvasive, and reliable identification of pancreatic cancer precursor cysts.PMID:35410389 | DOI:10.1007/s00216-022-04040-4
Source: Analytical and Bioanalytical Chemistry - April 12, 2022 Category: Chemistry Authors: Lucia Sarcina Fabrizio Viola Francesco Modena Rosaria Anna Picca Paolo Bollella Cinzia Di Franco Nicola Cioffi Mario Caironi Ronald Österbacka Irene Esposito Gaetano Scamarcio Luisa Torsi Fabrizio Torricelli Eleonora Macchia Source Type: research
