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Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity. « Back to Top
Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

An overview of the research progress of BRCA gene mutations in breast cancer
Biochim Biophys Acta Rev Cancer. 2023 May 10:188907. doi: 10.1016/j.bbcan.2023.188907. Online ahead of print.ABSTRACTThe breast cancer susceptibility gene (BRCA) is an important tumor suppressor gene, including BRCA1 and BRCA2, a biomarker that assesses the risk of breast cancer and influences a patient's individualized treatment options. BRCA1/2 mutation (BRCAm) increases the risk of breast cancer. However, breast-conserving surgery is still an option for BRCAm, and prophylactic mastectomy and nipple-sparing mastectomy may also reduce the risk of breast cancer. BRCAm is sensitive to Poly (ADP-ribose) polymerase inhibitor ...
Source: Biochimica et Biophysica Acta - May 12, 2023 Category: Biochemistry Authors: Andi Wan Guozhi Zhang Dandan Ma Yi Zhang Xiaowei Qi Source Type: research

Investigation of the effects of overexpression of jumping translocation breakpoint (JTB) protein in MCF7 cells for potential use as a biomarker in breast cancer
Am J Cancer Res. 2022 Apr 15;12(4):1784-1823. eCollection 2022.ABSTRACTJumping translocation breakpoint (JTB) gene acts as a tumor suppressor or an oncogene in different malignancies, including breast cancer (BC), where it was reported as overexpressed. However, the molecular functions, biological processes and underlying mechanisms through which JTB protein causes increased cell growth, proliferation and invasion is still not fully deciphered. Our goal is to identify the functions of JTB protein by cellular proteomics approaches. MCF7 breast cancer cells were transfected with sense orientation of hJTB cDNA in HA, His and ...
Source: Cell Research - May 9, 2022 Category: Cytology Authors: Madhuri Jayathirtha Anca-Narcisa Neagu Danielle Whitham Shelby Alwine Costel C Darie Source Type: research

Inhibition of Estrogen Receptor Signaling as a Strategy for Radiosensitization of ER+ Breast Cancers
CONCLUSION: Our data suggest that endocrine therapies may be effectively used to radiosensitize ER+ breast tumors. This work also supports further clinical investigation of the timing of RT for patients receiving ET as concurrent use may be more effective than sequential, especially as ET prior to RT is increasingly used as a bridging therapy during the COVID pandemic.PMID:34701020 | DOI:10.1016/j.ijrobp.2021.07.842
Source: Ann Oncol - October 27, 2021 Category: Cancer & Oncology Authors: A R Michmerhuizen A Pesch R Schwartz K Wilder-Romans M Liu A Harold R Azaria D Hayes J Rae L J Pierce C Speers Source Type: research

Cancers, Vol. 13, Pages 833: Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer
In conclusion, we identified and characterized the clinical value of a group of genomic alterations in ubiquitination, SUMOylation, and neddylation enzymes, with potential for drug development in breast cancer.
Source: Cancers - February 17, 2021 Category: Cancer & Oncology Authors: Jes ús Fuentes-Antrás Ana Luc ía Alcaraz-Sanabria Esther Caba ñas Morafraile Mar ía del Mar Noblejas-López Eva Mar ía Galán-Moya Mariona Baliu-Pique Igor L ópez-Cade Vanesa Garc ía-Barberán Pedro P érez-Segura Ar ánzazu Manzano Atanasio Pandi Tags: Article Source Type: research

Abstract 2739: Specific interaction of human MGMT with ER-{alpha} in breast cancer cells: Co-degradation of MGMT and ER- {alpha} proteins by either fulvestrant or O6-benzylguanine and its therapeutic significance
This study investigated whether i) MGMT is modulated by endocrine therapies, ii) MGMT interacts with ER-signaling components and iii) if such findings are exploitable for improved breast cancer treatment. The ER-α positive cell lines MCF-7, T47D and ER- α negative MDAMB 468 cells, all MGMT-proficient, were treated with Fulvestrant (Faslodex, ICI 182, 780) or O6-benzylguanine (BG) in various experiments. Fulvestrant is a pure antiestrogen that binds to ER without eliciting any transcriptional effects, but leads to the receptor degradation through the ubiquitin-proteasome (ub-P) pathway. BG is a specific pseudosubstrate fo...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Srivenugopal, K. S., Paranjpe, A. Tags: Experimental and Molecular Therapeutics Source Type: research